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  • 黄质宁

    Xanthinin

    黄质宁
    产品编号 CFN99644
    CAS编号 153483-31-9
    分子式 = 分子量 C17H22O5 = 306.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Xanthium sibiricum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄质宁 CFN99644 153483-31-9 1mg QQ客服:215959384
    黄质宁 CFN99644 153483-31-9 5mg QQ客服:215959384
    黄质宁 CFN99644 153483-31-9 10mg QQ客服:215959384
    黄质宁 CFN99644 153483-31-9 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Madras (India)
  • Michigan State University (USA)
  • University of Queensland (Australia)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Texas A&M University (USA)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Monash University Malaysia (Malaysia)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Amity University (India)
  • Aarhus University (Denmark)
  • Universidade Federal de Santa Catarina (Brazil)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Periyar University (India)
  • Mahatma Gandhi University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • JABS2020, 14:2(2020)
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Chin Med.2022, 17(1):66.
  • Exp Mol Med.2020, 52(4):629-642.
  • Food Chem Toxicol.2023, 176:113785.
  • Int Immunopharmacol.2020, 90:107268.
  • Acta horticulturae2017, 1158:257-268
  • Arch Pharm Res.2015, 38(6):1080-9
  • Research Square2022, rs.3.rs-1948239
  • Turkish Journal of Pharmaceutical Sciences2022, DOI: 10.4274
  • Heliyon.2023, 9:e21652.
  • Molecules.2021, 26(16):4722.
  • Molecules.2020, 25(23):5636.
  • Food and Chemical Toxicology2020, 111221
  • JOTCSA.2023, 10(4); 893-902.
  • FASEB J.2022, 36(7):e22387.
  • Genes (Basel).2021, 12(7):1024.
  • Sci Adv.2018, 4(10)
  • J Chromatogr A.2022, 1685:463640.
  • Food Funct.2022, doi: 10.1039
  • Appl. Sci. 2021, 11(23),11099.
  • Enzyme Microb Technol.2019, 122:64-73
  • Int J Mol Sci.2020, 21(19):7209.
  • ...
  • 生物活性
    Description: Xanthinin is a plant growth-regulating compound from Xanthium pennsylvanicum, it is also a phytotoxic xanthanolide, can inhibit the growth of plants.
    In vitro:
    Molecules. 2015 Apr 17;20(4):7034-47.
    Phytochemical compositions and biological activities of essential oil from Xanthium strumarium L.[Pubmed: 25898416]
    The chemical composition of the essential oil (EO) from fresh cocklebur (Xanthium strumarium L.) leaves was investigated by GC-MS.
    METHODS AND RESULTS:
    The antimicrobial activity of the EO was tested against Gram-positive and Gram-negative bacteria and fungi. Scolicidal activity was assayed against Echinococcus granulosus protoscolices. In total, 34 compounds were identified, accounting for 98.96% of the EO. The main compounds in the EO were cis-β-guaiene (34.2%), limonene (20.3%), borneol (11.6%), bornyl acetate (4.5%), β-cubebene (3.8%), sabinene (3.6%), phytol (3.1%), β-selinene (2.8%), camphene (2.2%), α-cubebene (2.4%), β-caryophyllene (1.9%), α-pinene (1.8%) and xanthinin (1.04%). The antibacterial and antifungal screening of the EO showed that all assayed concentrations significantly inhibited the growth of Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger (MIC = 0.5 ± 0.1, 1.3 ± 0.0, 4.8 ± 0.0, 20.5 ± 0.3, 55.2 ± 0.0 and 34.3 ± 0.0 µg/mL, respectively). The scolicidal assay indicated that the EO exhibited a significant activity against E. granulosus protoscolices.
    CONCLUSIONS:
    To the best of our knowledge, this is the first report on the scolicidal activity of X. strumarium. Because of the emergence of antimicrobial drug resistance, the study of new effective natural chemotherapeutic agents, such as the X. strumarium EO, possibly with low side effects, represents a very promising approach in biomedical research.
    Eur J Med Chem. 2015 Jan 27;90:491-6.
    Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties.[Pubmed: 25481815]

    METHODS AND RESULTS:
    The aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L. favours the conversion of xanthinin (1) to xanthatin (2) via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established.
    CONCLUSIONS:
    This natural compound shows significant cytotoxicity against the Hep-G2 cell line and our experimental results reveal its strong anti-angiogenesis capacity in vitro. The structure of xanthatin is determined by spectroscopic methods and for the first time confirmed by X-ray diffraction.
    Allelopathy J., 2015, 35(1):77-86.
    Selective phytotoxicity of xanthinin and xanthatin from invasive weed Xanthium italicum Morretti on test plants[Reference: WebLink]

    METHODS AND RESULTS:
    Two phytotoxic xanthanolides, Xanthinin and xanthatin, were isolated from the leaves and fruits of invasive weed, Xanthium italicum Morretti, commonly known as Italian cocklebur. They slightly inhibited the seedling growth of Italian cocklebur, but were very inhibitory to lettuce, ryegrass and two indigenous species (African rue and redroot pigweed). Xanthinin significantly decreased the growth of lettuce (Lectuca sativa L.), ryegrass (Lolium multiforum Lam.), Syrian me (Peganum harmala L.) and redroot pigweed (Amaranthus retroflexus L.) even at low concentration (10 mu g/mL). In contrast, the root length of Italian cocklebur slightly inhibited (2%) compared to control at 50 mu g/mL Xanthinin treatment. The application of xanthatin also inhibited the growth of receiver plants. Ryegrass and Syrian rue were most sensitive species, whose root growth was inhibited by 78% and 96%, respectively, at 50 mu g/mL dose of xanthatin, while the root length of Italian cocklebur was only inhibited by 23%. In fact, Italian cocklebur was the only receiver species that survived at 1 mg/mL xanthatin and Xanthinin treatment.
    CONCLUSIONS:
    Our results suggested that the selective phytotoxicity of Italian cocklebur and other species facilitated its successful invasion. This is the first report on the phytotoxic activity of xanthatin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2637 mL 16.3185 mL 32.6371 mL 65.2742 mL 81.5927 mL
    5 mM 0.6527 mL 3.2637 mL 6.5274 mL 13.0548 mL 16.3185 mL
    10 mM 0.3264 mL 1.6319 mL 3.2637 mL 6.5274 mL 8.1593 mL
    50 mM 0.0653 mL 0.3264 mL 0.6527 mL 1.3055 mL 1.6319 mL
    100 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.6527 mL 0.8159 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (1R-顺式)-5-甲基-alpha-亚甲基-4-(3-氧代丁基)-3-环庚烯-1-乙酸; 4-Oxobedfordiaic acid CFN97170 68799-38-2 C15H22O3 = 250.3 5mg QQ客服:1413575084
    3-Hydroxy-4,15-dinor-1(5)-xanthen-12,8-olide; 3-Hydroxy-4,15-dinor-1(5)-xanthen-12,8-olide CFN99095 1093207-99-8 C13H20O3 = 224.3 5mg QQ客服:2056216494
    叶黄制菌素; Xanthatin CFN98315 26791-73-1 C15H18O3 = 246.3 5mg QQ客服:1413575084
    8-Epixanthatin; 8-Epixanthatin CFN89507 30890-35-8 C15H18O3 = 246.30 5mg QQ客服:1413575084
    6alpha-Hydroxytomentosin; 6alpha-Hydroxytomentosin CFN89001 1232676-22-0 C15H20O4 = 264.32 5mg QQ客服:215959384
    黄质宁; Xanthinin CFN99644 153483-31-9 C17H22O5 = 306.4 5mg QQ客服:215959384
    旋覆花内酯; Britannilactone CFN92601 33620-72-3 C15H22O4 = 266.3 20mg QQ客服:1413575084
    1-O-乙酰旋覆花内酯; 1-O-Acetyl britannilactone CFN90219 681457-46-5 C17H24O5 = 266.34 20mg QQ客服:2056216494
    1,6-O,O-二乙酰大花旋覆花内酯; 1,6-O,O-Diacetylbritannilactone CFN89518 1286694-67-4 C19H26O6 = 350.40 5mg QQ客服:1457312923
    1-O-乙酰-6β-O-异丁酰旋覆花内酯; 1-O-Acetyl-6beta-O-Isobutyrylbritannilactone CFN92598 1087072-50-1 C21H30O6 = 378.5 5mg QQ客服:1413575084

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