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  • 叶黄制菌素

    Xanthatin

    叶黄制菌素
    产品编号 CFN98315
    CAS编号 26791-73-1
    分子式 = 分子量 C15H18O3 = 246.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The fruits of Xanthium sibiricum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    叶黄制菌素 CFN98315 26791-73-1 1mg QQ客服:2056216494
    叶黄制菌素 CFN98315 26791-73-1 5mg QQ客服:2056216494
    叶黄制菌素 CFN98315 26791-73-1 10mg QQ客服:2056216494
    叶黄制菌素 CFN98315 26791-73-1 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Ioannina (Greece)
  • Heidelberg University (Germany)
  • Kyushu University (Japan)
  • University of Malaya (Malaysia)
  • Copenhagen University (Denmark)
  • University of Illinois at Chicago (USA)
  • Calcutta University (India)
  • Seoul National University (Korea)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Periyar University (India)
  • Universidad Industrial de Santander (Colombia)
  • National Research Council of Canada (Canada)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Universitas islam negeri Jakarta (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Pain Res.2022, 15:3469-3478.
  • J Ethnopharmacol.2016, 192:370-381
  • Applied Biological Chemistry2022, 65(85).
  • BMC Complement Altern Med.2019, 19(1):11
  • Hum Exp Toxicol.2023, 42:9603271231171642.
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Nutrients.2019, 12(1)
  • Horticulturae2023, 9(2), 213.
  • The Journal of Korean Medicine2022, 43(3): 79-93.
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • J Plant Biotechnol.2023, 50:070-075.
  • Environ Toxicol.2021, 36(9):1848-1856.
  • Dent Mater J.2020, 39(4):690-695
  • J Nat Med.2018, 72(3):734-744
  • Foods.2022, 12(1):136.
  • Compounds.2023, 3(1), 169-179.
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Sci Rep.2020, 10:4495(2020)
  • J of Advanced Scientific R.2020, 11(3), p109-120.
  • Front. Physiol.2022, 790345.
  • J Nat Med.2017, 71(2):380-388
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Front Pharmacol.2022, 13:883475.
  • ...
  • 生物活性
    Description: Xanthatin is a novel potent inhibitor of VEGFR2 signaling, has significant antitumor activity against a variety of cancer cells through cell cycle arrest and apoptosis induction, it can inhibit angiogenesis and tumor growth in breast cancer cells. Xanthatin has bactericidal and fungicidal activity, including against Colletotrichum gloesporoides, Trichothecium roseum, Bacillus cereus and Staphylococcus aureus.
    Targets: Wnt/β-catenin | GSK-3 | STAT | Bcl-2/Bax | p65 | NF-kB | Chk | Antifection | VEGFR
    In vitro:
    Lett. Appl. Microbiol., 1994, 18(4): 206-8.
    Antimicrobial activity of xanthatin from Xanthium spinosum L.[Reference: WebLink]

    METHODS AND RESULTS:
    Dichloromethane extracts from Xanthium spinosum L. were fractionated and the fractions tested for their bactericidal and fungicidal activity. From the active fraction, a compound was isolated and identified as xanthatin (I).
    CONCLUSIONS:
    Xanthatin was active against Colletotrichum gloesporoides, Trichothecium roseum, Bacillus cereus and Staphylococcus aureus.
    Int J Clin Exp Pathol. 2015 Sep 1;8(9):10355-64.
    Xanthatin, a novel potent inhibitor of VEGFR2 signaling, inhibits angiogenesis and tumor growth in breast cancer cells.[Pubmed: 26617743 ]
    Anti-angiogenesis targeting vascular endothelial growth factor receptor 2 (VEGFR2) has emerged as an important tool for cancer treatment.
    METHODS AND RESULTS:
    In this study, we described a novel VEGFR2 inhibitor, xanthatin, which inhibits tumor angiogenesis and growth. The biochemical profiles of xanthatin were investigated using kinase assay, migration assay, tube formation, Matrigel plug assay, western blot, immunofluorescence and human tumor xenograft model. Xanthatin significantly inhibited growth, migration and tube formation of human umbilical vascular endothelial cell as well as inhibited vascular endothelial growth factor (VEGF)-stimulated angiogenesis. In addition, it inhibited VEGF-induced phosphorylation of VEGFR2 and its downstream signaling regulator. Moreover, xanthatin directly inhibit proliferation of breast cancer cells MDA-MB-231. Oral administration of xanthatin could markedly inhibit human tumor xenograft growth and decreased microvessel densities (MVD) in tumor sections.
    CONCLUSIONS:
    Taken together, these preclinical evaluations suggest that xanthatin inhibits angiogenesis and may be a promising anticancer drug candidate.
    In vivo:
    Phytomedicine. 2013 Jul 15;20(10):865-73.
    Characterization of xanthatin: anticancer properties and mechanisms of inhibited murine melanoma in vitro and in vivo.[Pubmed: 23664560]
    Anti-cancer investigations on Xanthatin mainly focus on in vitro experiments. We herein reported the anti-tumor effects of Xanthatin both in vitro and in vivo.
    METHODS AND RESULTS:
    MTS assay results showed that Xanthatin had a remarkable anti-proliferative effect on B16-F10 cells. Moreover, the expression of β-catenin was up-regulated both in vitro and in vivo. Animal studies further revealed that Xanthatin killed the tumor cells around the blood vessels which contributes to reduce microvascular density extremely.
    CONCLUSIONS:
    All these results indicate that Xanthatin inhibited murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt/β-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0601 mL 20.3004 mL 40.6009 mL 81.2018 mL 101.5022 mL
    5 mM 0.812 mL 4.0601 mL 8.1202 mL 16.2404 mL 20.3004 mL
    10 mM 0.406 mL 2.03 mL 4.0601 mL 8.1202 mL 10.1502 mL
    50 mM 0.0812 mL 0.406 mL 0.812 mL 1.624 mL 2.03 mL
    100 mM 0.0406 mL 0.203 mL 0.406 mL 0.812 mL 1.015 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Curcumadionol; Curcumadionol CFN92653 1235984-45-8 C15H20O3 = 248.3 5mg QQ客服:1457312923
    (1R-顺式)-5-甲基-alpha-亚甲基-4-(3-氧代丁基)-3-环庚烯-1-乙酸; 4-Oxobedfordiaic acid CFN97170 68799-38-2 C15H22O3 = 250.3 5mg QQ客服:3257982914
    3-Hydroxy-4,15-dinor-1(5)-xanthen-12,8-olide; 3-Hydroxy-4,15-dinor-1(5)-xanthen-12,8-olide CFN99095 1093207-99-8 C13H20O3 = 224.3 5mg QQ客服:215959384
    叶黄制菌素; Xanthatin CFN98315 26791-73-1 C15H18O3 = 246.3 5mg QQ客服:2159513211
    8-Epixanthatin; 8-Epixanthatin CFN89507 30890-35-8 C15H18O3 = 246.30 5mg QQ客服:2159513211
    6alpha-Hydroxytomentosin; 6alpha-Hydroxytomentosin CFN89001 1232676-22-0 C15H20O4 = 264.32 5mg QQ客服:215959384
    黄质宁; Xanthinin CFN99644 153483-31-9 C17H22O5 = 306.4 5mg QQ客服:1457312923
    旋覆花内酯; Britannilactone CFN92601 33620-72-3 C15H22O4 = 266.3 20mg QQ客服:215959384
    1-O-乙酰旋覆花内酯; 1-O-Acetyl britannilactone CFN90219 681457-46-5 C17H24O5 = 266.34 20mg QQ客服:2056216494
    1,6-O,O-二乙酰大花旋覆花内酯; 1,6-O,O-Diacetylbritannilactone CFN89518 1286694-67-4 C19H26O6 = 350.40 5mg QQ客服:2159513211

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