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  • 1-O-乙酰旋覆花内酯

    1-O-Acetyl britannilactone

    产品编号 CFN90219
    CAS编号 681457-46-5
    分子式 = 分子量 C17H24O5 = 266.34
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Inula japonica Thunb.
    产品名称 产品编号 CAS编号 包装 QQ客服
    1-O-乙酰旋覆花内酯 CFN90219 681457-46-5 10mg QQ客服:1457312923
    1-O-乙酰旋覆花内酯 CFN90219 681457-46-5 20mg QQ客服:1457312923
    1-O-乙酰旋覆花内酯 CFN90219 681457-46-5 50mg QQ客服:1457312923
    1-O-乙酰旋覆花内酯 CFN90219 681457-46-5 100mg QQ客服:1457312923
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
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  • National Hellenic Research Foundation (Greece)
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  • Kazusa DNA Research Institute (Japan)
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  • 生物活性
    Description: 1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGFR-Src-FAK signaling. 1-O-Acetyl britannilactone may be one anti-inflammatory drug which inhibits the expression of COX-2 gene by blocking NF-κB activation and thus suppresses the inflammatory response to LPS in vascular smooth muscle cells.
    Targets: p65 | NF-kB | COX | IkB | VEGFR | Src | FAK | IKK
    In vitro:
    Acta Phytophylacica Sinica, 2008 , 35 (6) :551-6.
    Separation and analysis of 1-O-acetylbritannilactone from Inula japonica and determination of antifungal activity[Reference: WebLink]
    In order to clarify the main antifungal compound of Inula japonica,the chloroform extraction of crude extract from I.japonica flowers was separated and compound 1-O-Acetyl britannilactone (ABL) was obtained.
    The content of the compound ABL in flowers crude extract was tested with high performance liquid chromatography.The inhibitory effects of compound ABL against Sphaerotheca fuliginea,Pseudoperonospora cubensis,Botrytis cinerea,Alternaria solani and Phytophthora infestans were tested.The chemical structure of ABL reference substance was elucidated by using ultraviolet spectrometry(UV),infrared spectroscopy(IR),nuclear magnetic resonance(NMR).The purity of ABL reference substance was 99.5%,which satisfies the need of reference substances of traditional Chinese medicines.A method of high performance liquid chromatography was used for the determination of the content of ABL in crude extract from I.japonica flowers(it's 2.45%),then the content of ABL in I.japonica was calculated(it's about 0.25%).
    Inhibitory activities of compound ABL against the five phytopathogenic fungi were different,which against the cystospore germination of P.infestans was significant,the inhibition rate was 100% at the concentration 0.1 mg/mL.
    Chinese Journal of Cell Biology, 2007 , 29 (2) :267-71.
    1-o-acetylbritannilactone Inhibits Inflammatory Response by Suppressing NF-κB Activation[Reference: WebLink]
    Immunocytochemistry and Western blot analysis were adopted to measure the nuclear translo-cation of NF-κB p65 and the expression of IκB-α, cyclo-oxygenase-2 (COX-2).
    Electrophoretic mobility shift assay (EMSA) was performed to detect DNA-binding activity of NF-κB in vascular smooth muscle cells (VSMC) pre-treated with ABL. Western blot and immunocytochemistry analysis showed that lipopolysaccharide (LPS) treatment resulted in increasing nuclear translocation of NF-κB p65, and declining levels of IκB-α in VSMC. However, 1-O-Acetyl britannilactone (ABL) pretreatment inhibited the nuclear translocation of p65 and degradation of IκB-α in-duced by LPS, and the inhibitory effect of ABL was concentration-dependent. LPS increased the binding of nuclear extracts from VSMC induced by LPS to double strands oligonucleotide probe containing NF-κB binding site using EMSA. The shift bands were abolished when a 100-fold excess of unlabeled NF-κB oligonucleotide probe was included. Pretreatment with ABL significantly reduced the nuclear level of NF-κB and declined the binding activity of nuclear extracts with DNA probe induced by LPS. Furthermore, ABL consequentially inhibited the expression of NF-κB-dependent COX-2 gene induced by LPS.
    These results suggest that ABL may be one anti-inflammatory drug which inhibits the expression of COX-2 gene by blocking NF-κB activation and thus suppresses the inflammatory response to LPS in VSMC.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7546 mL 18.773 mL 37.546 mL 75.092 mL 93.865 mL
    5 mM 0.7509 mL 3.7546 mL 7.5092 mL 15.0184 mL 18.773 mL
    10 mM 0.3755 mL 1.8773 mL 3.7546 mL 7.5092 mL 9.3865 mL
    50 mM 0.0751 mL 0.3755 mL 0.7509 mL 1.5018 mL 1.8773 mL
    100 mM 0.0375 mL 0.1877 mL 0.3755 mL 0.7509 mL 0.9386 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    二氢莪术双环烯酮; Dihydrocurcumenone CFN92649 142717-57-5 C15H24O2 = 236.4 5mg QQ客服:2056216494
    莪术双环烯酮; Curcumenone CFN92026 100347-96-4 C15H22O2 = 234.3 5mg QQ客服:2159513211
    Curcumadionol; Curcumadionol CFN92653 1235984-45-8 C15H20O3 = 248.3 5mg QQ客服:2056216494
    (1R-顺式)-5-甲基-alpha-亚甲基-4-(3-氧代丁基)-3-环庚烯-1-乙酸; 4-Oxobedfordiaic acid CFN97170 68799-38-2 C15H22O3 = 250.3 5mg QQ客服:215959384
    3-Hydroxy-4,15-dinor-1(5)-xanthen-12,8-olide; 3-Hydroxy-4,15-dinor-1(5)-xanthen-12,8-olide CFN99095 1093207-99-8 C13H20O3 = 224.3 5mg QQ客服:1413575084
    叶黄制菌素; Xanthatin CFN98315 26791-73-1 C15H18O3 = 246.3 5mg QQ客服:1413575084
    8-Epixanthatin; 8-Epixanthatin CFN89507 30890-35-8 C15H18O3 = 246.30 5mg QQ客服:2056216494
    6alpha-Hydroxytomentosin; 6alpha-Hydroxytomentosin CFN89001 1232676-22-0 C15H20O4 = 264.32 5mg QQ客服:3257982914
    黄质宁; Xanthinin CFN99644 153483-31-9 C17H22O5 = 306.4 5mg QQ客服:1413575084
    旋覆花内酯; Britannilactone CFN92601 33620-72-3 C15H22O4 = 266.3 20mg QQ客服:2159513211





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