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  • 条叶蓟素

    • 条叶蓟素

    Cirsiliol

    条叶蓟素
    		产品编号 CFN96508
    CAS编号 34334-69-5
    分子式 = 分子量 C17H14O7 = 330.29
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The aerial parts of Phyla nodiflora.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    条叶蓟素 CFN96508 34334-69-5 1mg QQ客服：215959384
    条叶蓟素 CFN96508 34334-69-5 5mg QQ客服：215959384
    条叶蓟素 CFN96508 34334-69-5 10mg QQ客服：215959384
    条叶蓟素 CFN96508 34334-69-5 20mg QQ客服：215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • FORTH-IMBB (Greece)
  • Ain Shams University (Egypt)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Chulalongkorn University (Thailand)
  • Northeast Normal University Changchun (China)
  • University of the Basque Country (Spain)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • University of British Columbia (Canada)
  • Monash University (Australia)
  • University Medical Center Mainz (Germany)
  • Mendel University in Brno (Czech Republic)
  • University of Queensland (Australia)
  • National Cancer Institute (USA)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Preprints2022, 202211.0388.v1.
  • Anat Rec2018, 24264
  • BMC Complement Altern Med.2014, 14:352
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Plants (Basel).2021, 10(6):1192.
  • Oncotarget.2017, 8(64):108006-108019
  • Microchemical Journal2023, 194:109249
  • J Agric Food Chem.2019, 67(27):7748-7754
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • Int Immunopharmacol.2021, 101(Pt A):108181.
  • Phytomedicine.2019, 67:153159
  • Int J Mol Med.2019, 43(6):2516-2522
  • Food Sci Biotechnol.2023, 32(7):997-1003.
  • J Food Sci.2021, 86(9):3810-3823.
  • European Journal of Integrative Medicine2018, 20:165-172
  • Environ Toxicol.2024, 39(3):1556-1566.
  • Plant Cell Physiol.2018, 59(1):128-141
  • Molecules.2021, 26(4):1084.
  • J of App. Res. on Med&Aromatic Plants2020, 100291.
  • Front Chem.2024, 12:1385844.
  • Antioxidants (Basel).2022, 11(10):1929.
  • Nutrients2020, 12(3):811.
  • Food Sci Nutr.2023, 11(9):5532-5542.
  • ...
    • 生物活性
    Description: Cirsiliol shows antioxidant, and anti-obesity effects, it can inhibit TG accumulation in 3T3-L1 preadipocytes. Cirsiliol and rhamnetin can act as promising radiosensitizers that enhance the radiotherapeutic efficacy by inhibiting radiation-induced Notch-1 signaling associated with radioresistance possibly via miR-34a-mediated pathways.
    Targets: NO | NF-kB
    In vitro:
    J Nat Med. 2014 Apr;68(2):414-20.
    Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells.[Pubmed: 24142543 ]

    METHODS AND RESULTS:
    We investigated the anti-obesity effect of the aerial part of Artemisia scoparia Waldst. et Kit. (Compositae). An 80 % aqueous EtOH extract of the aerial part inhibited triglyceride (TG) accumulation and the nitric oxide (NO) production activity. A new chromane derivative was isolated from the aerial part of A. scoparia Waldst. et Kit. along with 18 known compounds. The structure of the new chromane, scopariachromane (1), was elucidated by spectroscopic analyses. The inhibitory effects of the compounds on TG accumulation activity were examined. Among these, Cirsiliol (11) inhibited TG accumulation in 3T3-L1 preadipocytes. Jaceosidin (12) inhibited NO production in a murine macrophage-like cell line (RAW 264.7).
    CONCLUSIONS:
    These results indicate that the 80 % aqueous EtOH extract and compounds isolated from the aerial part of A. scoparia Waldst. et Kit. may improve obesity-related insulin resistance.
    J Biol Chem. 2013 Sep 20;288(38):27343-57.
    Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines.[Pubmed: 23902763 ]

    METHODS AND RESULTS:
    Treatment with rhamnetin or Cirsiliol reduced the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression. Indeed, rhamnetin and Cirsiliol increased the expression of tumor-suppressive microRNA, miR-34a, in a p53-dependent manner, leading to inhibition of Notch-1 expression. Consequently, reduced Notch-1 expression promoted apoptosis through significant down-regulation of the nuclear factor-κB pathway, resulting in a radiosensitizing effect on NSCLC cells. Irradiation-induced epithelial-mesenchymal transition was also notably attenuated in the presence of rhamnetin and Cirsiliol. Moreover, an in vivo xenograft mouse model confirmed the radiosensitizing and epithelial-mesenchymal transition inhibition effects of rhamnetin and Cirsiliol we observed in vitro. In these mice, tumor volume was significantly reduced by combinational treatment with irradiation and rhamnetin or Cirsiliol compared with irradiation alone.
    CONCLUSIONS:
    Taken together, our findings provided evidence that rhamnetin and Cirsiliol can act as promising radiosensitizers that enhance the radiotherapeutic efficacy by inhibiting radiation-induced Notch-1 signaling associated with radioresistance possibly via miR-34a-mediated pathways.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0276 mL 15.1382 mL 30.2764 mL 60.5528 mL 75.6911 mL
    5 mM 0.6055 mL 3.0276 mL 6.0553 mL 12.1106 mL 15.1382 mL
    10 mM 0.3028 mL 1.5138 mL 3.0276 mL 6.0553 mL 7.5691 mL
    50 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.2111 mL 1.5138 mL
    100 mM 0.0303 mL 0.1514 mL 0.3028 mL 0.6055 mL 0.7569 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3,5,6,7,8,4'-六甲氧基黄酮; 3,5,6,7,8,4'-hexamethoxyflavone CFN91805 34170-18-8 C21H22O8 = 402.4 5mg QQ客服：1457312923
    3,3',4',5,6,7,8-七甲氧基黄酮; 3,3',4',5,6,7,8-heptamethoxyflavone CFN95021 1178-24-1 C22H24O9 = 432.4 10mg QQ客服：3257982914
    4'-羟基黄烷酮; 4'-Hydroxyflavone CFN91544 4143-63-9 C15H10O3 = 238.2 20mg QQ客服：2159513211
    4'-甲氧基黄酮; 4'-Methoxyflavone CFN70361 4143-74-2 C16H12O3 = 252.3 5mg QQ客服：2056216494
    7-羟基-4'-甲氧基黄酮; 7-Hydroxy-4'-methoxyflavone CFN70378 487-24-1 C16H12O4 = 268.3 5mg QQ客服：1413575084
    3',4'-二羟基黄酮; 3',4'-Dihydroxyflavone CFN70360 4143-64-0 C15H10O4 = 254.2 20mg QQ客服：2159513211
    3',4'-二甲氧基黄酮; 3',4'-Dimethoxyflavone CFN70359 4143-62-8 C17H14O4 = 282.3 20mg QQ客服：2159513211
    3',4',7-三羟基黄酮; 7,3',4'-Trihydroxyflavone CFN97786 2150-11-0 C15H10O5 = 270.24 20mg QQ客服：3257982914
    3',4',7,8-四羟基黄酮; 3',4',7,8-Tetrahydroxyflavone CFN70342 3440-24-2 C15H10O6 = 286.2 5mg QQ客服：1413575084
    木犀草素; 3',4',5,7-四羟基黄酮; Luteolin CFN98784 491-70-3 C15H10O6 = 286.2 20mg QQ客服：215959384

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