Info: Read More
  • 中药标准品生产商,产品定制服务
  • 甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮

    Sinensetin

    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮
    产品编号 CFN99599
    CAS编号 2306-27-6
    分子式 = 分子量 C20H20O7 = 372.37
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The fruits of Citrus aurantium L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮 CFN99599 2306-27-6 10mg QQ客服:215959384
    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮 CFN99599 2306-27-6 20mg QQ客服:215959384
    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮 CFN99599 2306-27-6 50mg QQ客服:215959384
    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮 CFN99599 2306-27-6 100mg QQ客服:215959384
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • CSIRO - Agriculture Flagship (Australia)
  • FORTH-IMBB (Greece)
  • Subang Jaya Medical Centre (Malaysia)
  • Melbourne University (Australia)
  • The Ohio State University (USA)
  • Wageningen University (Netherlands)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • University of Hawaii Cancer Center (USA)
  • Complutense University of Madrid (Spain)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Illinois at Chicago (USA)
  • University of Perugia (Italy)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci. Rep.2015, 14-23
  • Oncol Rep.2021, 46(1):143.
  • Life (Basel).2021, 11(12):1399.
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Life Sci.2022, 298:120488.
  • Int J Med Sci.2021, 18(10):2155-2161.
  • FEBS Lett.2021, 595(20):2608-2615.
  • Oncotarget.2017, 8(53):90925-90947
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • Int J Mol Sci.2019, 20(23):E6071
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Natural Product Communications2020, doi: 10.1177.
  • J of Applied Biological Chem.2020, 63(2):147-152
  • Appl. Sci. 2021, 11(23),11099.
  • Biochem Systematics and Ecology2017, 11-18
  • Korean J Pain.2021, 34(4):405-416.
  • Nat Prod Commun.2018, 10.1177
  • Evid Based Complement Alternat Med.2021, 2021:5023536.
  • Front Microbiol.2022, 13:835463.
  • Metabolites.2023, 13(5):625.
  • Journal of Food and Drug Analysis2023, 31(3), 9.
  • ...
  • 生物活性
    Description: Sinensetin is a polymethoxylated flavonoids in citrus fruit, as a novel antiangiogenesis agent, has potential for anti-carcinogenesis, antitumor, and cardiovascular protective activities. Sinensetin has antioxidative effect and has anti-inflammatory by regulating the protein level of inhibitorκB-α, it enhances adipogenesis and lipolysis by increasing cAMP levels in adipocytes.
    Targets: cAMP | AMPK | NOS | COX | NO | PGE | TNF-α | STAT | IkB | IKK
    In vitro:
    Biol Pharm Bull. 2015 Apr 1;38(4):552-8.
    Sinensetin Enhances Adipogenesis and Lipolysis by Increasing Cyclic Adenosine Monophosphate Levels in 3T3-L1 Adipocytes.[Pubmed: 25735898]
    Sinensetin is a rare polymethoxylated flavone (PMF) found in certain citrus fruits.
    METHODS AND RESULTS:
    In this study, we investigated the effects of sinensetin on lipid metabolism in 3T3-L1 cells. Sinensetin promoted adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, which did not contain 3-isobutyl-1-methylxanthine. Sinensetin up-regulated expression of the adipogenic transcription factors peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein (C/EBP) α, and sterol regulatory element-binding protein 1c. It also potentiated expression of C/EBPβ and activation of cAMP-responsive element-binding protein. Sinensetin enhanced activation of protein kinase A and increased intracellular cAMP levels in 3T3-L1 preadipocytes. In mature 3T3-L1 adipocytes, sinensetin stimulated lipolysis via a cAMP pathway.
    CONCLUSIONS:
    Taken together, these results suggest that sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels in adipocytes..
    In vivo:
    Planta Med. 2012 May;78(8):779-86.
    Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation.[Pubmed: 22516932]
    Cytokines and other inflammatory mediators, such as prostaglandin E₂ (PGE₂) and nitric oxide (NO) produced by cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, activate and drive inflammation and therefore serve as targets for anti-inflammatory drug development. Orthosiphon stamineus is an indigenous medicinal plant of Southeast Asia that has been traditionally used in the treatment of rheumatoid arthritis, gout, and other inflammatory disorders.
    METHODS AND RESULTS:
    The present study investigated the anti-inflammatory properties of Orthosiphon stamineus leaf chloroform extract (CE), its flavonoid-containing CE fraction 2 (CF2), and the flavonoids eupatorin, eupatorin-5-methyl ether (TMF), and sinensetin, identified from the CF2. It was found that CE (20 and 50 μg/mL) and CF2 (20 and 50 μg/mL) inhibited iNOS expression and NO production, as well as PGE₂ production. Eupatorin and sinensetin inhibited iNOS and COX-2 expression and the production of NO (IC₅₀ 5.2 μM and 9.2 μM for eupatorin and sinensetin, respectively) and PGE₂ (IC₅₀ 5.0 μM and 2.7 μM for eupatorin and sinensetin, respectively) in a dose-dependent manner. The extracts and the compounds also inhibited tumor necrosis factor α (TNF-α) production (IC₅₀ 5.0 μM and 2.7 μM for eupatorin and sinensetin, respectively). Eupatorin and sinensetin inhibited lipopolysaccharide (LPS)-induced activation of transcription factor signal transducers and activators of transcription 1α (STAT1α). Furthermore, eupatorin (50 mg/kg i. p.) and sinensetin (50 mg/kg i. p.) inhibited carrageenan-induced paw inflammation in mice.
    CONCLUSIONS:
    The results suggest that CE and CF2, as well as the known constituents of CF2, i.e., eupatorin and sinensetin, have meaningful anti-inflammatory properties which may be utilized in the development of novel anti-inflammatory treatments.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6855 mL 13.4275 mL 26.855 mL 53.71 mL 67.1375 mL
    5 mM 0.5371 mL 2.6855 mL 5.371 mL 10.742 mL 13.4275 mL
    10 mM 0.2686 mL 1.3428 mL 2.6855 mL 5.371 mL 6.7138 mL
    50 mM 0.0537 mL 0.2686 mL 0.5371 mL 1.0742 mL 1.3428 mL
    100 mM 0.0269 mL 0.1343 mL 0.2686 mL 0.5371 mL 0.6714 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    泽兰黄酮; 6-甲氧基藤黄菌素; 6-Methoxyluteolin CFN92706 520-11-6 C16H12O7 = 316.3 20mg QQ客服:1413575084
    条叶蓟素; Cirsiliol CFN96508 34334-69-5 C17H14O7 = 330.29 5mg QQ客服:215959384
    Leucanthogenin; Leucanthogenin CFN92953 99615-00-6 C17H14O8 = 346.29 5mg QQ客服:3257982914
    毒马草黄酮; Sideritoflavone CFN96399 70360-12-2 C18H16O8 = 360.3 5mg QQ客服:1457312923
    栀子黄素D; Gardenin D CFN95133 29202-00-4 C19H18O8 = 374.4 5mg QQ客服:1457312923
    香叶木素; Diosmetin CFN90210 520-34-3 C16H12O6 = 300.26 20mg QQ客服:215959384
    Pilloin; Pilloin CFN96503 32174-62-2 C17H14O6 = 314.29 10mg QQ客服:3257982914
    3'-羟基-5,7,4'-三甲氧基黄酮; 3'-Hydroxy-5,7,4'-trimethoxyflavone CFN95396 33554-52-8 C18H16O6 = 328.3 5mg QQ客服:2056216494
    去甲氧基矢车菊黄酮素; Desmethoxycentaureidin CFN98234 22934-99-2 C17H14O7 = 330.3 5mg QQ客服:1457312923
    半齿泽兰素; Eupatorin CFN97418 855-96-9 C18H16O7 = 344.3 10mg QQ客服:2056216494

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产