甜橙黄酮； 5,6,7,3',4'-五甲氧基黄酮

Sinensetin

	产品编号	CFN99599
	CAS编号	2306-27-6
	分子式 = 分子量	C₂₀H₂₀O₇ = 372.37
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The fruits of Citrus aurantium L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
甜橙黄酮； 5,6,7,3',4'-五甲氧基黄酮	CFN99599	2306-27-6	10mg	QQ客服：1457312923
甜橙黄酮； 5,6,7,3',4'-五甲氧基黄酮	CFN99599	2306-27-6	20mg	QQ客服：1457312923
甜橙黄酮； 5,6,7,3',4'-五甲氧基黄酮	CFN99599	2306-27-6	50mg	QQ客服：1457312923
甜橙黄酮； 5,6,7,3',4'-五甲氧基黄酮	CFN99599	2306-27-6	100mg	QQ客服：1457312923

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Description:

Sinensetin is a polymethoxylated flavonoids in citrus fruit, as a novel antiangiogenesis agent, has potential for anti-carcinogenesis, antitumor, and cardiovascular protective activities. Sinensetin has antioxidative effect and has anti-inflammatory by regulating the protein level of inhibitorκB-α, it enhances adipogenesis and lipolysis by increasing cAMP levels in adipocytes.

Targets:

cAMP | AMPK | NOS | COX | NO | PGE | TNF-α | STAT | IkB | IKK

In vitro:

Biol Pharm Bull. 2015 Apr 1;38(4):552-8.

Sinensetin Enhances Adipogenesis and Lipolysis by Increasing Cyclic Adenosine Monophosphate Levels in 3T3-L1 Adipocytes.[Pubmed: 25735898]

Sinensetin is a rare polymethoxylated flavone (PMF) found in certain citrus fruits.
METHODS AND RESULTS:
In this study, we investigated the effects of sinensetin on lipid metabolism in 3T3-L1 cells. Sinensetin promoted adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, which did not contain 3-isobutyl-1-methylxanthine. Sinensetin up-regulated expression of the adipogenic transcription factors peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein (C/EBP) α, and sterol regulatory element-binding protein 1c. It also potentiated expression of C/EBPβ and activation of cAMP-responsive element-binding protein. Sinensetin enhanced activation of protein kinase A and increased intracellular cAMP levels in 3T3-L1 preadipocytes. In mature 3T3-L1 adipocytes, sinensetin stimulated lipolysis via a cAMP pathway.
CONCLUSIONS:
Taken together, these results suggest that sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels in adipocytes..

In vivo:

Planta Med. 2012 May;78(8):779-86.

Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation.[Pubmed: 22516932]

Cytokines and other inflammatory mediators, such as prostaglandin E₂ (PGE₂) and nitric oxide (NO) produced by cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, activate and drive inflammation and therefore serve as targets for anti-inflammatory drug development. Orthosiphon stamineus is an indigenous medicinal plant of Southeast Asia that has been traditionally used in the treatment of rheumatoid arthritis, gout, and other inflammatory disorders.
METHODS AND RESULTS:
The present study investigated the anti-inflammatory properties of Orthosiphon stamineus leaf chloroform extract (CE), its flavonoid-containing CE fraction 2 (CF2), and the flavonoids eupatorin, eupatorin-5-methyl ether (TMF), and sinensetin, identified from the CF2. It was found that CE (20 and 50 μg/mL) and CF2 (20 and 50 μg/mL) inhibited iNOS expression and NO production, as well as PGE₂ production. Eupatorin and sinensetin inhibited iNOS and COX-2 expression and the production of NO (IC₅₀ 5.2 μM and 9.2 μM for eupatorin and sinensetin, respectively) and PGE₂ (IC₅₀ 5.0 μM and 2.7 μM for eupatorin and sinensetin, respectively) in a dose-dependent manner. The extracts and the compounds also inhibited tumor necrosis factor α (TNF-α) production (IC₅₀ 5.0 μM and 2.7 μM for eupatorin and sinensetin, respectively). Eupatorin and sinensetin inhibited lipopolysaccharide (LPS)-induced activation of transcription factor signal transducers and activators of transcription 1α (STAT1α). Furthermore, eupatorin (50 mg/kg i. p.) and sinensetin (50 mg/kg i. p.) inhibited carrageenan-induced paw inflammation in mice.
CONCLUSIONS:
The results suggest that CE and CF2, as well as the known constituents of CF2, i.e., eupatorin and sinensetin, have meaningful anti-inflammatory properties which may be utilized in the development of novel anti-inflammatory treatments.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
毒马草黄酮; Sideritoflavone	CFN96399	70360-12-2	C₁₈H₁₆O₈ = 360.3	5mg	QQ客服：1413575084
栀子黄素D; Gardenin D	CFN95133	29202-00-4	C₁₉H₁₈O₈ = 374.4	5mg	QQ客服：1413575084
香叶木素; Diosmetin	CFN90210	520-34-3	C₁₆H₁₂O₆ = 300.26	20mg	QQ客服：1413575084
Pilloin; Pilloin	CFN96503	32174-62-2	C₁₇H₁₄O₆ = 314.29	10mg	QQ客服：215959384
3'-羟基-5,7,4'-三甲氧基黄酮; 3'-Hydroxy-5,7,4'-trimethoxyflavone	CFN95396	33554-52-8	C₁₈H₁₆O₆ = 328.3	5mg	QQ客服：3257982914
去甲氧基矢车菊黄酮素; Desmethoxycentaureidin	CFN98234	22934-99-2	C₁₇H₁₄O₇ = 330.3	5mg	QQ客服：2056216494
半齿泽兰素; Eupatorin	CFN97418	855-96-9	C₁₈H₁₆O₇ = 344.3	10mg	QQ客服：2056216494
半齿泽兰素-5-甲醚; Eupatorin-5-methylether	CFN70313	21764-09-0	C₁₉H₁₈O₇ = 358.4	5mg	QQ客服：2159513211
金圣草(黄)素; Chrysoeriol	CFN98785	491-71-4	C₁₆H₁₂O₆ = 300.3	5mg	QQ客服：2056216494
4 '-甲基金圣草素; 4'-Methylchrysoeriol	CFN91826	4712-12-3	C₁₇H₁₄O₆ = 314.3	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6855 mL	13.4275 mL	26.855 mL	53.71 mL	67.1375 mL
5 mM	0.5371 mL	2.6855 mL	5.371 mL	10.742 mL	13.4275 mL
10 mM	0.2686 mL	1.3428 mL	2.6855 mL	5.371 mL	6.7138 mL
50 mM	0.0537 mL	0.2686 mL	0.5371 mL	1.0742 mL	1.3428 mL
100 mM	0.0269 mL	0.1343 mL	0.2686 mL	0.5371 mL	0.6714 mL

甜橙黄酮； 5,6,7,3',4'-五甲氧基黄酮

Sinensetin

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