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  • 甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮

    Sinensetin

    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮
    产品编号 CFN99599
    CAS编号 2306-27-6
    分子式 = 分子量 C20H20O7 = 372.37
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The fruits of Citrus aurantium L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮 CFN99599 2306-27-6 10mg QQ客服:215959384
    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮 CFN99599 2306-27-6 20mg QQ客服:215959384
    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮 CFN99599 2306-27-6 50mg QQ客服:215959384
    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮 CFN99599 2306-27-6 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Monash University (Australia)
  • Kazusa DNA Research Institute (Japan)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • University of Ioannina (Greece)
  • University of Helsinki (Finland)
  • University of British Columbia (Canada)
  • Seoul National University of Science and Technology (Korea)
  • University of Hull (United Kingdom)
  • Florida A&M University (USA)
  • Kitasato University (Japan)
  • Auburn University (USA)
  • Deutsches Krebsforschungszentrum (Germany)
  • Tohoku University (Japan)
  • Ateneo de Manila University (Philippines)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean J of Crop Science2019, 452-458
  • Antioxidants (Basel).2023, 13(1):12.
  • Mol Biol Rep.2024, 51(1):117.
  • J Agric Food Chem.2021, 69(14):4210-4222.
  • Institute of Food Science & Technology2021, 56(11).
  • Molecules.2024, 29(5):1048.
  • The University of Manitoba2021, 35690.
  • J Sci Food Agric.2018, 98(3):1153-1161
  • Molecules.2018, 23(10):E2638
  • PLoS One.2021, 16(9):e0257243.
  • Molecules.2022, 27(19):6681.
  • Food Bioscience2023, 52:102412
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Phytomedicine.2018, 47:48-57
  • LWT2020, 126:109313
  • Cancer Lett. 2023, 18:216584.
  • Br J Pharmacol.2016, 173(2):396-410
  • Food Chem.2017, 228:301-314
  • J Pharm Biomed Anal.2023, 234:115570.
  • Food Chem.2022, 378:131975.
  • Universiti Tunku Aboul Rahman2023, 6263.
  • Int J Mol Sci.2021, 22(17):9400.
  • Environ Toxicol.2024, 39(4):2417-2428.
  • ...
  • 生物活性
    Description: Sinensetin is a polymethoxylated flavonoids in citrus fruit, as a novel antiangiogenesis agent, has potential for anti-carcinogenesis, antitumor, and cardiovascular protective activities. Sinensetin has antioxidative effect and has anti-inflammatory by regulating the protein level of inhibitorκB-α, it enhances adipogenesis and lipolysis by increasing cAMP levels in adipocytes.
    Targets: cAMP | AMPK | NOS | COX | NO | PGE | TNF-α | STAT | IkB | IKK
    In vitro:
    Biol Pharm Bull. 2015 Apr 1;38(4):552-8.
    Sinensetin Enhances Adipogenesis and Lipolysis by Increasing Cyclic Adenosine Monophosphate Levels in 3T3-L1 Adipocytes.[Pubmed: 25735898]
    Sinensetin is a rare polymethoxylated flavone (PMF) found in certain citrus fruits.
    METHODS AND RESULTS:
    In this study, we investigated the effects of sinensetin on lipid metabolism in 3T3-L1 cells. Sinensetin promoted adipogenesis in 3T3-L1 preadipocytes growing in incomplete differentiation medium, which did not contain 3-isobutyl-1-methylxanthine. Sinensetin up-regulated expression of the adipogenic transcription factors peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein (C/EBP) α, and sterol regulatory element-binding protein 1c. It also potentiated expression of C/EBPβ and activation of cAMP-responsive element-binding protein. Sinensetin enhanced activation of protein kinase A and increased intracellular cAMP levels in 3T3-L1 preadipocytes. In mature 3T3-L1 adipocytes, sinensetin stimulated lipolysis via a cAMP pathway.
    CONCLUSIONS:
    Taken together, these results suggest that sinensetin enhances adipogenesis and lipolysis by increasing cAMP levels in adipocytes..
    In vivo:
    Planta Med. 2012 May;78(8):779-86.
    Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation.[Pubmed: 22516932]
    Cytokines and other inflammatory mediators, such as prostaglandin E₂ (PGE₂) and nitric oxide (NO) produced by cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, activate and drive inflammation and therefore serve as targets for anti-inflammatory drug development. Orthosiphon stamineus is an indigenous medicinal plant of Southeast Asia that has been traditionally used in the treatment of rheumatoid arthritis, gout, and other inflammatory disorders.
    METHODS AND RESULTS:
    The present study investigated the anti-inflammatory properties of Orthosiphon stamineus leaf chloroform extract (CE), its flavonoid-containing CE fraction 2 (CF2), and the flavonoids eupatorin, eupatorin-5-methyl ether (TMF), and sinensetin, identified from the CF2. It was found that CE (20 and 50 μg/mL) and CF2 (20 and 50 μg/mL) inhibited iNOS expression and NO production, as well as PGE₂ production. Eupatorin and sinensetin inhibited iNOS and COX-2 expression and the production of NO (IC₅₀ 5.2 μM and 9.2 μM for eupatorin and sinensetin, respectively) and PGE₂ (IC₅₀ 5.0 μM and 2.7 μM for eupatorin and sinensetin, respectively) in a dose-dependent manner. The extracts and the compounds also inhibited tumor necrosis factor α (TNF-α) production (IC₅₀ 5.0 μM and 2.7 μM for eupatorin and sinensetin, respectively). Eupatorin and sinensetin inhibited lipopolysaccharide (LPS)-induced activation of transcription factor signal transducers and activators of transcription 1α (STAT1α). Furthermore, eupatorin (50 mg/kg i. p.) and sinensetin (50 mg/kg i. p.) inhibited carrageenan-induced paw inflammation in mice.
    CONCLUSIONS:
    The results suggest that CE and CF2, as well as the known constituents of CF2, i.e., eupatorin and sinensetin, have meaningful anti-inflammatory properties which may be utilized in the development of novel anti-inflammatory treatments.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6855 mL 13.4275 mL 26.855 mL 53.71 mL 67.1375 mL
    5 mM 0.5371 mL 2.6855 mL 5.371 mL 10.742 mL 13.4275 mL
    10 mM 0.2686 mL 1.3428 mL 2.6855 mL 5.371 mL 6.7138 mL
    50 mM 0.0537 mL 0.2686 mL 0.5371 mL 1.0742 mL 1.3428 mL
    100 mM 0.0269 mL 0.1343 mL 0.2686 mL 0.5371 mL 0.6714 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-羟基-4'-甲氧基黄酮; 7-Hydroxy-4'-methoxyflavone CFN70378 487-24-1 C16H12O4 = 268.3 5mg QQ客服:1413575084
    3',4'-二羟基黄酮; 3',4'-Dihydroxyflavone CFN70360 4143-64-0 C15H10O4 = 254.2 20mg QQ客服:2159513211
    3',4'-二甲氧基黄酮; 3',4'-Dimethoxyflavone CFN70359 4143-62-8 C17H14O4 = 282.3 20mg QQ客服:2056216494
    3',4',7-三羟基黄酮; 7,3',4'-Trihydroxyflavone CFN97786 2150-11-0 C15H10O5 = 270.24 20mg QQ客服:2056216494
    3',4',7,8-四羟基黄酮; 3',4',7,8-Tetrahydroxyflavone CFN70342 3440-24-2 C15H10O6 = 286.2 5mg QQ客服:215959384
    木犀草素; 3',4',5,7-四羟基黄酮; Luteolin CFN98784 491-70-3 C15H10O6 = 286.2 20mg QQ客服:3257982914
    羟基芫花素; Hydroxygenkwanin CFN98021 20243-59-8 C16H12O6 = 300.3 20mg QQ客服:2056216494
    5,7-二甲氧基木犀草素; 5,7-Dimethoxyluteolin CFN91001 N/A C17H14O6 = 314.3 10mg QQ客服:3257982914
    5,6,3',4'-四羟基-7-甲氧基黄酮; Pedalitin CFN96045 22384-63-0 C16H12O7 = 316.3 5mg QQ客服:2159513211
    泽兰黄酮; 6-甲氧基藤黄菌素; 6-Methoxyluteolin CFN92706 520-11-6 C16H12O7 = 316.3 20mg QQ客服:2159513211

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