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  • 4',5,8-三羟基-3',6,7-三甲氧基黄酮

    Isothymonin

    4',5,8-三羟基-3',6,7-三甲氧基黄酮
    产品编号 CFN92436
    CAS编号 99615-01-7
    分子式 = 分子量 C18H16O8 = 360.3
    产品纯度 >=98%
    物理属性 Yellow cryst.
    化合物类型 Flavonoids
    植物来源 The herbs of Mentha longifolia
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4',5,8-三羟基-3',6,7-三甲氧基黄酮 CFN92436 99615-01-7 1mg QQ客服:1413575084
    4',5,8-三羟基-3',6,7-三甲氧基黄酮 CFN92436 99615-01-7 5mg QQ客服:1413575084
    4',5,8-三羟基-3',6,7-三甲氧基黄酮 CFN92436 99615-01-7 10mg QQ客服:1413575084
    4',5,8-三羟基-3',6,7-三甲氧基黄酮 CFN92436 99615-01-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2023, 28(8):3414.
  • Horticulture Research2023, uhad164.
  • Chem Res Toxicol.2023, 36(2):213-229.
  • Biomed Pharmacother.2019, 111:262-269
  • Cells.2021, 10(10):2633.
  • Life (Basel).2022, 12(12):2107.
  • Environ Toxicol.2023, tox.23999.
  • iScience.2023, 26(9):107602.
  • TCI CO.2019, US20190151281A1
  • Phytomedicine.2015, 22(11):1027-36
  • ACS Pharmacol. Transl. Sci.2023, 3c00129.
  • Int J Mol Sci.2022, 23(1):538.
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • Phytomedicine.2020, 153440.
  • Natural Product Communications2020, doi: 10.1177.
  • JMicrobiol Biotech Food Sci2021, e4289.
  • Food Structure2023, 36:100324.
  • Natural Product Communications2020, doi: 10.1177.
  • Research on Crops.2017, 18(3):569
  • Enzyme Microb Technol.2022, 153:109941.
  • National University of Pharmacy2022, 1:73-76
  • Int J Mol Med.2019, 43(6):2516-2522
  • Anal Bioanal Chem. 2016, 408(15)
  • ...
  • 生物活性
    Description: Isothymonin has antioxidant activity.It displays cyclooxygenase-1 inhibitory activity.
    Targets: COX
    In vitro:
    Phytomedicine. 2000 Mar;7(1):7-13.
    Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn.[Pubmed: 10782484]

    METHODS AND RESULTS:
    Anti-oxidant bioassay-directed extraction of the fresh leaves and stems of Ocimum sanctum and purification of the extract yielded the following compounds; cirsilineol [1], cirsimaritin [2], isothymusin [3], Isothymonin [4], apigenin [5], rosmarinic acid [6], and appreciable quantities of eugenol. The structures of compounds 1-6 were established using spectroscopic methods. Compounds 1 and 5 were isolated previously from O. sanctum whereas compounds 2 and 3 are here identified for the first time from O. sanctum. Eugenol, a major component of the volatile oil, and compounds 1, 3, 4, and 6 demonstrated good antioxidant activity at 10-microM concentrations. Anti-inflammatory activity or cyclooxygenase inhibitory activity of these compounds were observed. Eugenol demonstrated 97% cyclooxygenase-1 inhibitory activity when assayed at 1000-microM concentrations. Compounds 1, 2, and 4-6 displayed 37, 50, 37, 65, and 58% cyclooxygenase-1 inhibitory activity, respectively, when assayed at 1000-microM concentrations. Eugenol and compounds 1, 2, 5, and 6 demonstrated cyclooxygenase-2 inhibitory activity at slightly higher levels when assayed at 1000-microM concentrations.
    CONCLUSIONS:
    The activities of compounds 1-6 were comparable to ibuprofen, naproxen, and aspirin at 10-, 10-, and 1000-microM concentrations, respectively. These results support traditional uses of O. sanctum and identify the compounds responsible.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7755 mL 13.8773 mL 27.7546 mL 55.5093 mL 69.3866 mL
    5 mM 0.5551 mL 2.7755 mL 5.5509 mL 11.1019 mL 13.8773 mL
    10 mM 0.2775 mL 1.3877 mL 2.7755 mL 5.5509 mL 6.9387 mL
    50 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.1102 mL 1.3877 mL
    100 mM 0.0278 mL 0.1388 mL 0.2775 mL 0.5551 mL 0.6939 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,7-二甲氧基木犀草素; 5,7-Dimethoxyluteolin CFN91001 N/A C17H14O6 = 314.3 10mg QQ客服:2159513211
    5,6,3',4'-四羟基-7-甲氧基黄酮; Pedalitin CFN96045 22384-63-0 C16H12O7 = 316.3 5mg QQ客服:2056216494
    泽兰黄酮; 6-甲氧基藤黄菌素; 6-Methoxyluteolin CFN92706 520-11-6 C16H12O7 = 316.3 20mg QQ客服:3257982914
    条叶蓟素; Cirsiliol CFN96508 34334-69-5 C17H14O7 = 330.29 5mg QQ客服:215959384
    Leucanthogenin; Leucanthogenin CFN92953 99615-00-6 C17H14O8 = 346.29 5mg QQ客服:2159513211
    毒马草黄酮; Sideritoflavone CFN96399 70360-12-2 C18H16O8 = 360.3 5mg QQ客服:1457312923
    栀子黄素D; Gardenin D CFN95133 29202-00-4 C19H18O8 = 374.4 5mg QQ客服:2056216494
    香叶木素; Diosmetin CFN90210 520-34-3 C16H12O6 = 300.26 20mg QQ客服:1413575084
    Pilloin; Pilloin CFN96503 32174-62-2 C17H14O6 = 314.29 10mg QQ客服:3257982914
    3'-羟基-5,7,4'-三甲氧基黄酮; 3'-Hydroxy-5,7,4'-trimethoxyflavone CFN95396 33554-52-8 C18H16O6 = 328.3 5mg QQ客服:1457312923

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