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  • 5-去甲基甜橙黄酮

    5-Demethylsinensetin

    5-去甲基甜橙黄酮
    产品编号 CFN95415
    CAS编号 21763-80-4
    分子式 = 分子量 C19H18O7 = 358.34
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Artemisia princeps
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5-去甲基甜橙黄酮 CFN95415 21763-80-4 1mg QQ客服:2159513211
    5-去甲基甜橙黄酮 CFN95415 21763-80-4 5mg QQ客服:2159513211
    5-去甲基甜橙黄酮 CFN95415 21763-80-4 10mg QQ客服:2159513211
    5-去甲基甜橙黄酮 CFN95415 21763-80-4 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Complutense University of Madrid (Spain)
  • Massachusetts General Hospital (USA)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • China Medical University (Taiwan)
  • Charles Sturt University (Denmark)
  • Chiang Mai University (Thailand)
  • University of Wollongong (Australia)
  • Texas A&M University (USA)
  • Universidad Industrial de Santander (Colombia)
  • Auburn University (USA)
  • Monash University Malaysia (Malaysia)
  • Ateneo de Manila University (Philippines)
  • Srinakharinwirot University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Food Biochem.2021, 45(7):e13774.
  • Nutrients.2021, 13(10):3414.
  • Evid Based Complement Alternat Med.2021, 8855980.
  • Food Funct.2022, 13(14):7638-7649.
  • Sci Rep.2023, 13(1):7475.
  • Res Rep Urol.2022, 14:313-326.
  • University of Limpopo2016, 1777
  • Clin Exp Pharmacol Physiol.2020, doi: 10.1111
  • Acta Physiologiae Plantarum2016, 38:7
  • J.of Traditional&Complementary Med.2022, 10.1016:j.jtcme.
  • Mol Med Rep.2014, 9(5):1653-9
  • Applied Biological Chem. 2020, 26(63).
  • Journal of Ginseng Research2021, 15 June.
  • Applied Physics B2021, 127(92).
  • J Holistic Integrative Pharm.2023, 4(1):14-28
  • Front Pharmacol.2020, 11:683.
  • FASEB J.2019, 33(2):2026-2036
  • United States Patent Application2020, 20200038363
  • Pharmacognosy Journal, 2021, 13(5).
  • Int J Mol Sci.2018, 19(9):E2681
  • Environ Toxicol.2021, doi: 10.1002
  • Phytother Res.2018, 32(5):923-932
  • Preprints2022, 2022030063.
  • ...
  • 生物活性
    Description: 5-desmethylsinensetin, possesses antiprotozoal activity. 5-desmethylsinensetin shows IC50 values of 0.4 μg/mL on T. cruzi epimastigotes and 75.1 μg/mL on trypomastigotes, respectively
    In vitro:
    Acta Crystallogr C Struct Chem . 2021 Sep 1;77(Pt 9):505-512.
    Anthelmintic flavonoids and other compounds from Combretum glutinosum Perr. ex DC (Combretaceae) leaves[Pubmed: 34482293]
    A chemical study of the hydro-ethanol extract of the leaves of Combretum glutinosum resulted in the isolation of nine compounds, including 5-demethylsinensetin (1), umuhengerin (2), (20S,24R)-ocotillone (3), lupeol (4), β-sitosterol (5), oleanolic acid (6), betulinic acid (7), corymbosin (8) and β-sitosterol glucoside (9). Four compounds have been isolated for the first time from the genus Combretum [viz. (1), (2), (3) and (8)]. The crystal structures of flavonoid (2), C20H20O8, Z' = 2, and triterpene (3), C30H50O3, Z' = 1, have been determined for the first time; the latter confirmed the absolute configuration of native (20S,24R)-ocotillone previously derived from the crystal structures of related derivatives. The molecules of (3) are linked into supramolecular chains by intermolecular O-H...O hydrogen bonds. The crude extracts obtained by aqueous decoction and hydro-ethanolic maceration, as well as the nine isolated compounds, were tested for their anthelmintic activity on the larvae and adult worms of Haemonchus contortus, a hematophage that causes parasitic disorders in small ruminants. The evaluated anthelmintic activity showed that the extracts at different doses, as well as all the compounds tested at 150 μg ml-1, inhibited the migration of the larvae and the motility of the adult worms of the parasite compared with the phosphate buffer solution negative reference control. The best activity was obtained with flavonoids (1), (2) and (8) on both stages of the parasite. The flavones that showed good activity can be used for the further development of other derivatives, which could increase the anthelmintic efficacy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7906 mL 13.9532 mL 27.9065 mL 55.8129 mL 69.7661 mL
    5 mM 0.5581 mL 2.7906 mL 5.5813 mL 11.1626 mL 13.9532 mL
    10 mM 0.2791 mL 1.3953 mL 2.7906 mL 5.5813 mL 6.9766 mL
    50 mM 0.0558 mL 0.2791 mL 0.5581 mL 1.1163 mL 1.3953 mL
    100 mM 0.0279 mL 0.1395 mL 0.2791 mL 0.5581 mL 0.6977 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Leucanthogenin; Leucanthogenin CFN92953 99615-00-6 C17H14O8 = 346.29 5mg QQ客服:3257982914
    毒马草黄酮; Sideritoflavone CFN96399 70360-12-2 C18H16O8 = 360.3 5mg QQ客服:1457312923
    栀子黄素D; Gardenin D CFN95133 29202-00-4 C19H18O8 = 374.4 5mg QQ客服:215959384
    香叶木素; Diosmetin CFN90210 520-34-3 C16H12O6 = 300.26 20mg QQ客服:3257982914
    Pilloin; Pilloin CFN96503 32174-62-2 C17H14O6 = 314.29 10mg QQ客服:3257982914
    3'-羟基-5,7,4'-三甲氧基黄酮; 3'-Hydroxy-5,7,4'-trimethoxyflavone CFN95396 33554-52-8 C18H16O6 = 328.3 5mg QQ客服:2159513211
    去甲氧基矢车菊黄酮素; Desmethoxycentaureidin CFN98234 22934-99-2 C17H14O7 = 330.3 5mg QQ客服:215959384
    半齿泽兰素; Eupatorin CFN97418 855-96-9 C18H16O7 = 344.3 10mg QQ客服:215959384
    半齿泽兰素-5-甲醚; Eupatorin-5-methylether CFN70313 21764-09-0 C19H18O7 = 358.4 5mg QQ客服:215959384
    金圣草(黄)素; Chrysoeriol CFN98785 491-71-4 C16H12O6 = 300.3 5mg QQ客服:1413575084

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