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  • 5-羟基-7,3',4'-三甲氧基黄酮

    5-Hydroxy-3',4',7-trimethoxyflavone

    5-羟基-7,3',4'-三甲氧基黄酮
    产品编号 CFN98361
    CAS编号 29080-58-8
    分子式 = 分子量 C18H16O6 = 328.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Callicarpa bodinieri Levl.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5-羟基-7,3',4'-三甲氧基黄酮 CFN98361 29080-58-8 10mg QQ客服:2159513211
    5-羟基-7,3',4'-三甲氧基黄酮 CFN98361 29080-58-8 20mg QQ客服:2159513211
    5-羟基-7,3',4'-三甲氧基黄酮 CFN98361 29080-58-8 50mg QQ客服:2159513211
    5-羟基-7,3',4'-三甲氧基黄酮 CFN98361 29080-58-8 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Seoul National University (Korea)
  • Istanbul University (Turkey)
  • Celltrion Chemical Research Institute (Korea)
  • John Innes Centre (United Kingdom)
  • Sapienza University of Rome (Italy)
  • Yale University (USA)
  • The Australian National University (Australia)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Aveiro University (Portugal)
  • Semmelweis Unicersity (Hungary)
  • Chulalongkorn University (Thailand)
  • Chungnam National University (Korea)
  • Mendel University in Brno (Czech Republic)
  • Almansora University (Egypt)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2019, 10:1025
  • JABS2020, 14:2(2020)
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Antioxidants (Basel).2020, 9(4):326.
  • Plant Sci.2020, 301:110656.
  • Planta Med.2023, 2192-2281
  • Oxid Med Cell Longev.2021, 2021:6647107.
  • Antioxidants (Basel).2023, 12(7):1324.
  • Antioxidants (Basel).2022, 11(10):1929.
  • Biomed Pharmacother.2019, 116:108987
  • Molecules.2020, 25(21):5087.
  • Biomed Pharmacother.2020, 131:110673.
  • Phytomedicine.2019, 58:152893
  • PLoS One.2017, 12(3):e0173585
  • Int J Mol Sci.2021, 22(17):9400.
  • Toxicol In Vitro.2023, 93:105667.
  • Vietnam J. Chemistry2022, 60(2):211-222
  • Metabolites.2023, 13(5):625.
  • J Sep Sci.2019, 42(21):3352-3362
  • Thorac Cancer.2023, 14(21):2007-2017.
  • University of Manitoba2023, 37433.
  • Food Chem.2017, 221:1135-1144
  • Saudi Pharmaceutical Journal2023, 31(12):101829
  • ...
  • 生物活性
    Description: 5-Hydroxy-3',4',7-trimethoxyflavone has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml. 5-Hydroxy-3',4',7-trimethoxyflavone shows prominent inhibitory activity against soybean lipoxygenase, it can significantly inhibit nitric oxide production and induce reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-induced inflammation in RAW 264.7 macrophages.
    Targets: LOX | TNF-α | IL Receptor | PGE | COX | NOS | Antifection
    In vitro:
    Med. Chem. Res.,2016,25(9):1754-67.
    Protective effect of 5-hydroxy-3′,4′,7-trimethoxyflavone against inflammation induced by lipopolysaccharide in RAW 264.7 macrophage: in vitro study and in silico validation.[Reference: WebLink]
    The herb Lippia nodiflora L. (Verbenaceae) has been documented to exhibit anti-inflammatory, antipyretic, antitussive, antidiabetic, anticancer, and antimelanogenesis properties. In the present study, we aimed at evaluating the anti-inflammatory activity of 5-Hydroxy-3',4',7-trimethoxyflavone, a flavonoid from L. nodiflora, using lipopolysaccharide induced inflammation in RAW 264.7 macrophages.
    METHODS AND RESULTS:
    5-hydroxy-3′,4′,7-trimethoxyflavone significantly inhibited nitric oxide production and demonstrated slight reduction in prostaglandin-E2 level at tested concentrations. The production of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β, were obviously reduced by 5-Hydroxy-3',4',7-trimethoxyflavone in a concentration-dependent manner. Moreover, 5-Hydroxy-3',4',7-trimethoxyflavone significantly induced reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2, representing that inhibition occurs at the transcriptional level. In addition, we performed molecular docking and molecular dynamic simulations to study the interaction of 5-Hydroxy-3',4',7-trimethoxyflavone with inflammatory mediators such as inducible nitric oxide synthase and cyclooxygenase-2. Docking study showed its hydrogen bond interactions with key residues in the active site of inducible nitric oxide synthase and cyclooxygenase-2, enlightening its possible binding mode at the molecular level. The results of molecular dynamic simulations showed the stability of complexes and their interactions.
    CONCLUSIONS:
    Taken together, these findings envisage 5-Hydroxy-3',4',7-trimethoxyflavone as a potential candidate molecule for the progress of therapeutic strategy against inflammation-related diseases.
    Pharm. Biol.,2008, 41(7):483-6.
    Antifungal Flavonoids from Ballota glandulosissima.[Reference: WebLink]
    The flavonoids kumatakenin (1), pachypodol (2), 5-Hydroxy-3',4',7-trimethoxyflavone (3), velutin (4), salvigenin (5), retusin (6) and corymbosin (7) have been isolated from the aerial parts of Ballota glandulosissima Hub.-Mor & Patzak. Among them, 2–4 and 7 have not been reported previously in the genus Ballota.
    METHODS AND RESULTS:
    The antibacterial and antifungal activities of 1–4 and 6 were tested against Bacillus subtilis, Staphylococcus aureus, Staphylococcus faecalis, Echerichia coli, Pseudomonas aeruginosa, Candida albicans, Candida krusei and Candida galabrata.
    J.Appl. Pharm. Sci.,2016,6(1):102-6.
    Anti-infective Activities of Secondary Metabolites from Vitex pinnata.[Reference: WebLink]
    The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids β-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-Hydroxy-3',4',7-trimethoxyflavone(2), 5-hydroxy-7,4’-dimethoxy-flavone (3) and 5-hydroxy-3,3’,4’,7-tetramethoxyflavone (4). The structures of all isolated compounds were carried out by NMR and mass spectrometry.
    METHODS AND RESULTS:
    The isolated compounds were evaluated for their anti-infective activities against Trypanosoma brucei brucei and Microbacterium marinum. Compound 1-4 showed moderate antitrypanosomal activity with MIC values of 6.25μg/ml, 19.0, 21.0 and 17.0μM, respectively while no activity observed on anti-mycobacterial.
    CONCLUSIONS:
    This study is the first to report the presence of three flavones and their antitrypanosomal activity from V. pinnata.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.046 mL 15.23 mL 30.4599 mL 60.9199 mL 76.1499 mL
    5 mM 0.6092 mL 3.046 mL 6.092 mL 12.184 mL 15.23 mL
    10 mM 0.3046 mL 1.523 mL 3.046 mL 6.092 mL 7.615 mL
    50 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.2184 mL 1.523 mL
    100 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.6092 mL 0.7615 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-羟基-7,3',4'-三甲氧基黄酮; 5-Hydroxy-3',4',7-trimethoxyflavone CFN98361 29080-58-8 C18H16O6 = 328.3 20mg QQ客服:215959384
    异泽兰黄素; 泽兰林素; Eupatilin CFN90190 22368-21-4 C18H16O7 = 344.31 20mg QQ客服:215959384
    5-去甲基甜橙黄酮; 5-Demethylsinensetin CFN95415 21763-80-4 C19H18O7 = 358.34 10mg QQ客服:2056216494
    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮; Sinensetin CFN99599 2306-27-6 C20H20O7 = 372.37 20mg QQ客服:1413575084
    异橙黄酮; Isosinensetin CFN90806 17290-70-9 C20H20O7 = 372.4 20mg QQ客服:2056216494
    去甲基川陈皮素; 5-O-Demethylnobiletin CFN90921 2174-59-6 C20H20O8 = 388.4 20mg QQ客服:1413575084
    川陈皮素; 蜜橘黄素; 川皮亭; Nobiletin CFN98726 478-01-3 C21H22O8 = 402.4 20mg QQ客服:1457312923
    3,5,6,7,8,4'-六甲氧基黄酮; 3,5,6,7,8,4'-hexamethoxyflavone CFN91805 34170-18-8 C21H22O8 = 402.4 5mg QQ客服:2056216494
    3,3',4',5,6,7,8-七甲氧基黄酮; 3,3',4',5,6,7,8-heptamethoxyflavone CFN95021 1178-24-1 C22H24O9 = 432.4 10mg QQ客服:1413575084
    4'-羟基黄烷酮; 4'-Hydroxyflavone CFN91544 4143-63-9 C15H10O3 = 238.2 20mg QQ客服:1413575084

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