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  • 刺五加苷 E

    Eleutheroside E

    刺五加苷 E
    产品编号 CFN99984
    CAS编号 39432-56-9
    分子式 = 分子量 C34H46O18 = 742.73
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The roots of Eleutherococcus senticosus
    产品名称 产品编号 CAS编号 包装 QQ客服
    刺五加苷 E CFN99984 39432-56-9 10mg QQ客服:3257982914
    刺五加苷 E CFN99984 39432-56-9 20mg QQ客服:3257982914
    刺五加苷 E CFN99984 39432-56-9 50mg QQ客服:3257982914
    刺五加苷 E CFN99984 39432-56-9 100mg QQ客服:3257982914
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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  • MTT Agrifood Research Finland (Finland)
  • Seoul National University (Korea)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Otago (New Zealand)
  • China Medical University (Taiwan)
  • University of Wuerzburg (Germany)
  • Max Rubner-Institut (MRI) (Germany)
  • Agricultural Research Organization (ARO) (Israel)
  • University of Mysore (India)
  • University of Beira Interior (Portugal)
  • University of Limpopo (South Africa)
  • University of Bordeaux (France)
  • University of Zurich (Switzerland)
  • Lund University (Sweden)
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  • ...
  • 生物活性
    Description: Eleutheroside E(EE) has anti-inflammatory and protective effects in ischemia heart, the beneficial effect of EE may provide an effective and powerful strategy to alleviate behavioral alterations induced by sleep deprivation, it may influence to immune-enhancing through increasing the physical endurance capacity and immune cell activation. EE significantly decreases the inflammatory cell infiltration, pannus formation, cartilage damage, bone erosion of CIA mice, the generation of TNF-α and IL-6, the metabolism of drugs metabolized via CYP2C9 and CYP2E1.
    Targets: NF-kB | TNF-α | IL Receptor | P450 (e.g. CYP17) | IFN-γ
    In vitro:
    Oriental Pharmacy & Experimental Medicine, 2010, 10(3):191-9.
    Immune-enhancing effect of Acanthopanax Koreanum and its component, Eleutheroside E on the protein-energy malnourished C57bl/6 mice[Reference: WebLink]
    Acanthopanax Koreanum stem (AK) has been used in Korea as a tonic and sedative as well as a drug with ginseng like activities.
    The purpose of our present study was to investigate the effects of AK extract (AKE) and Eleutheroside E, major component of AKE on an exacerbated immune function through utilization of protein-energy malnutrition (PEM) diet by using forced swimming test (FST). The immobility time were significantly decreased in the AKE or Eleutheroside E-administrated group compared with the control group on the FST (P compared with unstimulated splenocytes but not interleukin (IL)-4. Eleutheroside E also significantly increased the IFN-\gamma production but not IL-2 and IL-4 in T cell line, MOLT-4 cells.
    These results suggest that AKE and Eleutheroside E may influence to immune-enhancing through increasing the physical endurance capacity and immune cell activation.
    In vivo:
    Eur J Pharmacol. 2011 May 11;658(2-3):150-5.
    The effect of Eleutheroside E on behavioral alterations in murine sleep deprivation stress model.[Pubmed: 21376030 ]
    Eleutheroside E (EE), a principal component of Eleutherococcus senticosus, has been reported to have anti-inflammatory and protective effects in ischemia heart etc. However, whether it can mitigate behavioral alterations induced by sleep deprivation, has not yet been elucidated. Numerous studies have demonstrated that memory deficits induced by sleep deprivation in experimental animals can be used as a model of behavioral alterations. The present study investigated the effect of EE, on cognitive performances and biochemical parameters of sleep-deprived mice.
    Animals were repeatedly treated with saline, 10 or 50mg/kg EE and sleep-deprived for 72 h by the multiple platform method. Briefly, groups of 5-6 mice were placed in water tanks (45 × 34 × 17 cm), containing 12 platforms (3 cm in diameter) each, surrounded by water up to 1cm beneath the surface or kept in their home cage. After sleep deprivation, mice showed significant behavioral impairment as evident by reduced latency entering into a dark chamber, locomotion and correctly rate in Y maze, and increased monoamines in hippocampus. However, repeated treatment with EE restored these behavioral and biochemical alterations in mice.
    In conclusion, the beneficial effect of EE may provide an effective and powerful strategy to alleviate behavioral alterations induced by sleep deprivation.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3464 mL 6.7319 mL 13.4638 mL 26.9277 mL 33.6596 mL
    5 mM 0.2693 mL 1.3464 mL 2.6928 mL 5.3855 mL 6.7319 mL
    10 mM 0.1346 mL 0.6732 mL 1.3464 mL 2.6928 mL 3.366 mL
    50 mM 0.0269 mL 0.1346 mL 0.2693 mL 0.5386 mL 0.6732 mL
    100 mM 0.0135 mL 0.0673 mL 0.1346 mL 0.2693 mL 0.3366 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Kobusin; Kobusin CFN89280 36150-23-9 C21H22O6 = 370.40 10mg QQ客服:2056216494
    (-)-细辛脂素; (-)-Asarinin CFN90144 133-04-0 C20H18O6 = 354.35 20mg QQ客服:2159513211
    (-)-表松脂酚; (-)-Epipinoresinol CFN92420 10061-38-8 C20H22O6 = 358.4 5mg QQ客服:2159513211
    连翘脂素; Phillygenin CFN90511 487-39-8 C21H24O6 = 372.41 20mg QQ客服:2056216494
    连翘苷; Phillyrin CFN99998 487-41-2 C27H34O11 = 534.56 20mg QQ客服:2056216494
    (+)-杜仲树脂酚双葡萄糖苷; (+)-Mediresinol Di-O-beta-D-glucopyranoside CFN91840 88142-63-6 C33H44O17 = 712.7 5mg QQ客服:1413575084
    辛夷脂素; Fargesin CFN98174 31008-19-2 C21H22O6 = 370.39 20mg QQ客服:1457312923
    细辛脂素; Asarinin CFN90628 133-05-1 C20H18O6 = 354.35 20mg QQ客服:2056216494
    刺五加苷D; Eleutheroside D CFN98510 79484-75-6 C34H46O18 = 742.72 10mg QQ客服:3257982914
    刺五加苷 E; Eleutheroside E CFN99984 39432-56-9 C34H46O18 = 742.73 20mg QQ客服:1457312923





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