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  • 3,3',4',5,6,7,8-七甲氧基黄酮

    3,3',4',5,6,7,8-heptamethoxyflavone

    3,3',4',5,6,7,8-七甲氧基黄酮
    产品编号 CFN95021
    CAS编号 1178-24-1
    分子式 = 分子量 C22H24O9 = 432.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The peels of Citrus nobilis Lour.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3,3',4',5,6,7,8-七甲氧基黄酮 CFN95021 1178-24-1 1mg QQ客服:1413575084
    3,3',4',5,6,7,8-七甲氧基黄酮 CFN95021 1178-24-1 5mg QQ客服:1413575084
    3,3',4',5,6,7,8-七甲氧基黄酮 CFN95021 1178-24-1 10mg QQ客服:1413575084
    3,3',4',5,6,7,8-七甲氧基黄酮 CFN95021 1178-24-1 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Nanjing University of Chinese Medicine (China)
  • University of Limpopo (South Africa)
  • Monash University Malaysia (Malaysia)
  • Subang Jaya Medical Centre (Malaysia)
  • Universidade Federal de Santa Catarina (Brazil)
  • Istanbul University (Turkey)
  • Macau University of Science and Technology (China)
  • University of Liège (Belgium)
  • Shanghai University of TCM (China)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Max Rubner-Institut (MRI) (Germany)
  • Texas A&M University (USA)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plants (Basel).2021, 10(4):702.
  • Mol Immunol. 2016, 78:121-132
  • Sci Rep.2021, 11(1):21038.
  • Key Engineering Materials2022, 931(47-53).
  • Front Pharmacol.2018, 9:236
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Toxicol Rep.2021, 8:1131-1142.
  • Front Cell Dev Biol.2020, 8:32.
  • Food Res Int.2020, 133:109130.
  • Horticulturae2020, 6(4),76.
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Phytochemistry.2021, 181:112539.
  • BMC Plant Biol.2020, 20(1):214.
  • BMC Plant Biol.2021, 21(1):60.
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • J Cell Mol Med.2023, 27(11):1592-1602.
  • Food Chem.2019, 275:746-753
  • Front Pharmacol.2017, 8:673
  • Universidade Estadual Paulista2017, 42785
  • JPC-Journal of Planar Chromatography2023, 36:179-190
  • Vietnam Journal of Science2022,64(2):69-75.
  • Journal of Life Science2017, 233-240
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • ...
  • 生物活性
    Description: 3,3',4',5,6,7,8-Heptamethoxyflavone(HMF) has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective effects; it inhibits collagenase activity and induces type I procollagen synthesis in HDFn cells, and against nitric oxide (NO) carcinogenesis.
    Targets: TNF-α | IL Receptor | gp120/CD4 | NO | MMP(e.g.TIMP) | MAPK | ERK | JNK | TGF-β/Smad
    In vitro:
    Int J Mol Sci. 2018 Feb 22;19(2). pii: E620.
    3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Inhibits Collagenase Activity and Induces Type I Procollagen Synthesis in HDFn Cells.[Pubmed: 29470423]
    Citrus fruits contain various types of flavonoids with powerful anti-aging and photoprotective effects on the skin, and have thus been attracting attention as potential, efficacious skincare agents.
    METHODS AND RESULTS:
    Here, we aimed to investigate the chemical composition of Citrus unshiu and its protective effects on photoaging. We isolated and identified a bioactive compound, 3,5,6,7,8,3',4'-heptamethoxyflavone (3,3',4',5,6,7,8-heptamethoxyflavone ,HMF), from C. unshiu peels using ethanol extraction and hexane fractionation. HMF inhibited collagenase activity and increased type I procollagen content in UV-induced human dermal fibroblast neonatal (HDFn) cells. HMF also suppressed the expression of matrix metalloproteinases 1 (MMP-1) and induced the expression of type I procollagen protein in UV-induced HDFn cells. Additionally, HMF inhibited ultraviolet B (UVB)-induced phosphorylation of the mitogen-activated protein kinases (MAPK) cascade signaling components-ERK, JNK, and c-Jun-which are involved in the induction of MMP-1 expression. Furthermore, HMF affected the TGF-β/Smad signaling pathway, which is involved in the regulation of type I procollagen expression. In particular, HMF induced Smad3 protein expression and suppressed Smad7 protein expression in UV-induced HDFn cells in a dose-dependent manner.
    CONCLUSIONS:
    These findings suggest a role for Citrusunshiu in the preparation of skincare products in future.
    In vivo:
    J Agric Food Chem. 2008 Oct 22;56(20):9399-403.
    Anti-inflammatory activity of an orange peel polymethoxylated flavone, 3',4',3,5,6,7,8-heptamethoxyflavone, in the rat carrageenan/paw edema and mouse lipopolysaccharide-challenge assays.[Pubmed: 18816060 ]
    The anti-inflammatory properties of 3',4',3,5,6,7,8-heptamethoxyflavone (3,3',4',5,6,7,8-heptamethoxyflavone ,HMF), a citrus polymethoxylated flavone, were studied in the bacterial lipopolysaccharide (LPS)-challenge/tumor necrosis factor-alpha (TNFalpha) response in mice and in the carrageenan/paw edema assay in rats.
    METHODS AND RESULTS:
    In each of these trials, HMF administered by intraperitoneal (ip) injection exhibited anti-inflammatory activity, whereas HMF administered orally (po) produced no effects. The inhibition observed in the LPS-challenge/TNFalpha assay correlated with the HMF levels in the blood sera of mice dosed (ip) with either 33 or 100 mg/kg body weight. Low levels of HMF (0.035 +/- 0.024 ppm) were detected in the blood sera of mice dosed orally [100 mg of HMF (suspended in vegetable oil)/kg], whereas ip injection led to higher levels (0.517 +/- 0.051 ppm). This may account for the different levels of anti-inflammatory effects observed in mice following ip vs oral HMF administration. HMF metabolites, including a number of mono- and di-demethylated HMF metabolites and their glucuronic acid conjugates, were also detected, but results of these studies suggest that the glucuronidated metabolites of HMF are inactive in these inflammation models.
    Cancer Lett. 2001 Feb 10;163(1):7-9.
    Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants.[Pubmed: 11163102]

    METHODS AND RESULTS:
    Nobiletin and 3,5,6,7,8,3',4'-heptamethoxyflavone (3,3',4',5,6,7,8-heptamethoxyflavone ,HPT), isolated from the peel of Citrus plants, were examined for the anti-tumor-initiating activity on two-stage carcinogenesis of mouse skin tumors induced by a nitric oxide donor, (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide, as an initiator and 12-O-tetradecanoylphorbol-13-acetate as a promoter.
    CONCLUSIONS:
    HPT exhibited the remarkable anti-tumor-initiating effect on mouse skin and it suggested the possibility of HPT being a chemopreventive agent against nitric oxide (NO) carcinogenesis.
    J Food Biochem . 2019 Jun;43(6):e12813.
    Anti-neuroinflammatory activities of extract and polymethoxyflavonoids from immature fruit peels of Citrus 'Hebesu'[Pubmed: 31353615]
    Abstract Chronic neuroinflammation is reported to be associated in the progression of many neurodegenerative diseases and there is an increasing interest for the natural products as neuroprotective and anti-neuroinflammatory agents. In present research, we evaluated the potential inhibitory effects of extract, fractions, and isolated compounds from Citrus 'Hebesu' on lipopolysaccharide (LPS)-induced inflammatory responses using BV-2 murine microglial cells. The dried methanol extract (CH) was suspended in water and partitioned with hexane and ethyl acetate to give hexane soluble (CHH), ethyl acetate soluble (CHE), and water soluble (CHW) fractions. The extract (CH) and fractions CHH and CHE inhibited the expression of mRNA encoding pro-inflammatory cytokine interleukin (IL)-1β. CHE and CHH were further purified by various column chromatographic methods to obtain hesperidin (1), tangeretin (2), 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone (3), 3,5,6,7,8,3',4'-heptamethoxyflavone (4), nobiletin (5), 3,4,5-trimethoxy-trans-cinnamic alcohol (6), and meranzin hydrate (7). Among them, three polymethoxyflavonoids, 3, 4, and 5 significantly inhibited the expression of IL-1β mRNA. PRACTICAL APPLICATIONS: Citrus 'Hebesu' is a local cultivar in Hyuga City, Miyazaki prefecture, Japan and its immature fruits are consumed with different food recipes. Till now, there is no detailed study on the chemical constituents and anti-neuroinflammatory activity of this cultivar. In this study, seven compounds were isolated from the peels of immature fruits. Methanol extract, hexane, and ethyl acetate fractions and three polymethoxyflavonoids showed a significant inhibitory activity against expression of IL-1β mRNA. Consumption of peels of Citrus 'Hebesu' might play important role in the prevention and treatment of neurodegenerative diseases, however, detailed mechanism based in vivo studies are necessary in future for providing more scientific evidences. Keywords: BV-2 cells; Citrus ‘Hebesu’; neuroinflammation; nobiletin; polymethoxyflavonoids.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3127 mL 11.5634 mL 23.1267 mL 46.2535 mL 57.8168 mL
    5 mM 0.4625 mL 2.3127 mL 4.6253 mL 9.2507 mL 11.5634 mL
    10 mM 0.2313 mL 1.1563 mL 2.3127 mL 4.6253 mL 5.7817 mL
    50 mM 0.0463 mL 0.2313 mL 0.4625 mL 0.9251 mL 1.1563 mL
    100 mM 0.0231 mL 0.1156 mL 0.2313 mL 0.4625 mL 0.5782 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4',5,8-三羟基-3',6,7-三甲氧基黄酮; Isothymonin CFN92436 99615-01-7 C18H16O8 = 360.3 5mg QQ客服:215959384
    5-羟基-7,3',4'-三甲氧基黄酮; 5-Hydroxy-3',4',7-trimethoxyflavone CFN98361 29080-58-8 C18H16O6 = 328.3 20mg QQ客服:2056216494
    异泽兰黄素; 泽兰林素; Eupatilin CFN90190 22368-21-4 C18H16O7 = 344.31 20mg QQ客服:1457312923
    5-去甲基甜橙黄酮; 5-Demethylsinensetin CFN95415 21763-80-4 C19H18O7 = 358.34 10mg QQ客服:2159513211
    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮; Sinensetin CFN99599 2306-27-6 C20H20O7 = 372.37 20mg QQ客服:3257982914
    异橙黄酮; Isosinensetin CFN90806 17290-70-9 C20H20O7 = 372.4 20mg QQ客服:2159513211
    去甲基川陈皮素; 5-O-Demethylnobiletin CFN90921 2174-59-6 C20H20O8 = 388.4 20mg QQ客服:215959384
    川陈皮素; 蜜橘黄素; 川皮亭; Nobiletin CFN98726 478-01-3 C21H22O8 = 402.4 20mg QQ客服:2159513211
    3,5,6,7,8,4'-六甲氧基黄酮; 3,5,6,7,8,4'-hexamethoxyflavone CFN91805 34170-18-8 C21H22O8 = 402.4 5mg QQ客服:1457312923
    3,3',4',5,6,7,8-七甲氧基黄酮; 3,3',4',5,6,7,8-heptamethoxyflavone CFN95021 1178-24-1 C22H24O9 = 432.4 10mg QQ客服:1457312923

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