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  • 去甲基川陈皮素

    5-O-Demethylnobiletin

    去甲基川陈皮素
    产品编号 CFN90921
    CAS编号 2174-59-6
    分子式 = 分子量 C20H20O8 = 388.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The peels of Citrus nobilis Lour.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    去甲基川陈皮素 CFN90921 2174-59-6 10mg QQ客服:2159513211
    去甲基川陈皮素 CFN90921 2174-59-6 20mg QQ客服:2159513211
    去甲基川陈皮素 CFN90921 2174-59-6 50mg QQ客服:2159513211
    去甲基川陈皮素 CFN90921 2174-59-6 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Helsinki (Finland)
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  • Florida International University (USA)
  • University of South Australia (Australia)
  • University of Parma (Italy)
  • National Cancer Institute (USA)
  • University of Zurich (Switzerland)
  • Vin?a Institute of Nuclear Sciences (Serbia)
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  • University of Eastern Finland (Finland)
  • Nicolaus Copernicus Uniwersity (Poland)
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  • University of the Basque Country (Spain)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Pharmacol.2021, 12:635510.
  • Separations2023, 10(11), 567;
  • Applied Biological Chemistry2022, 65(85).
  • Front Pharmacol.2019, 10:1025
  • Int J Mol Sci.2021, 22(17):9400.
  • Front Pharmacol.2021, 12:761922.
  • Natural Product Res.&Deve.2022, 1001-6880.
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Viruses.2017, 9(10)
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
  • Analytical Methods2018, 10(27)
  • Heinrich Heine University Dusseldorf2021, 62203.
  • Planta Med.2019, 85(9-10):766-773
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Preprints2022, 2022030063.
  • J Appl Biol Chem.2022, 65(4):pp.463-469.
  • Phytochemistry.2021, 181:112539.
  • Int J Mol Sci.2015, 16(1):1232-51
  • Biomolecules2021, 11(10),1513.
  • Spectrochim Acta A2019, 210:372-380
  • Asian Journal of Chemistry2014, 26(22):7811-7816
  • Molecules.2017, 22(11)
  • Int Immunopharmacol.2023, 125:111175.
  • ...
  • 生物活性
    Description: 5-O-Demethylnobiletin has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2.
    Targets: COX | LOX
    In vivo:
    Planta Med. 2006 Feb;72(2):136-42.
    Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum.[Pubmed: 16491449 ]

    METHODS AND RESULTS:
    We have studied the effect of 5-O-Demethylnobiletin ( 1) on both the inflammation of mouse ears induced by repeated application of 12- O-tetradecanoylphorbol 13-acetate (TPA) and the acute mouse paw oedemas induced by carrageenan and phospholipase A (2) (PLA (2)), and determined its activity on 5-lipoxygenase (5-LOX) and elastase release/activity. Compound 1 reduced the oedema formation, cell infiltration, and tissue damage in the inflammation induced by TPA in mouse ears, along with the acute oedema induced by carrageenan in mouse paws and the acute PLA (2)-induced oedema in mouse paws. The flavone inhibited leukotriene B (4) formation in rat neutrophils and elastase release in human neutrophils, but did not reduce the expression of cyclooxygenase-2 (COX-2) in murine RAW 264.7 macrophages.
    CONCLUSIONS:
    These experimental results suggest that 1 may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5747 mL 12.8733 mL 25.7467 mL 51.4933 mL 64.3666 mL
    5 mM 0.5149 mL 2.5747 mL 5.1493 mL 10.2987 mL 12.8733 mL
    10 mM 0.2575 mL 1.2873 mL 2.5747 mL 5.1493 mL 6.4367 mL
    50 mM 0.0515 mL 0.2575 mL 0.5149 mL 1.0299 mL 1.2873 mL
    100 mM 0.0257 mL 0.1287 mL 0.2575 mL 0.5149 mL 0.6437 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-羟基-4'-甲氧基黄酮; 7-Hydroxy-4'-methoxyflavone CFN70378 487-24-1 C16H12O4 = 268.3 5mg QQ客服:3257982914
    3',4'-二羟基黄酮; 3',4'-Dihydroxyflavone CFN70360 4143-64-0 C15H10O4 = 254.2 20mg QQ客服:1457312923
    3',4'-二甲氧基黄酮; 3',4'-Dimethoxyflavone CFN70359 4143-62-8 C17H14O4 = 282.3 20mg QQ客服:2159513211
    3',4',7-三羟基黄酮; 7,3',4'-Trihydroxyflavone CFN97786 2150-11-0 C15H10O5 = 270.24 20mg QQ客服:1413575084
    3',4',7,8-四羟基黄酮; 3',4',7,8-Tetrahydroxyflavone CFN70342 3440-24-2 C15H10O6 = 286.2 5mg QQ客服:1457312923
    木犀草素; 3',4',5,7-四羟基黄酮; Luteolin CFN98784 491-70-3 C15H10O6 = 286.2 20mg QQ客服:1413575084
    羟基芫花素; Hydroxygenkwanin CFN98021 20243-59-8 C16H12O6 = 300.3 20mg QQ客服:2056216494
    5,7-二甲氧基木犀草素; 5,7-Dimethoxyluteolin CFN91001 N/A C17H14O6 = 314.3 10mg QQ客服:1457312923
    5,6,3',4'-四羟基-7-甲氧基黄酮; Pedalitin CFN96045 22384-63-0 C16H12O7 = 316.3 5mg QQ客服:1413575084
    泽兰黄酮; 6-甲氧基藤黄菌素; 6-Methoxyluteolin CFN92706 520-11-6 C16H12O7 = 316.3 20mg QQ客服:2056216494

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