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  • 异橙黄酮

    • 异橙黄酮

    Isosinensetin

    异橙黄酮
    		产品编号 CFN90806
    CAS编号 17290-70-9
    分子式 = 分子量 C20H20O7 = 372.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The fruits of Citrus aurantium L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异橙黄酮 CFN90806 17290-70-9 10mg QQ客服：1413575084
    异橙黄酮 CFN90806 17290-70-9 20mg QQ客服：1413575084
    异橙黄酮 CFN90806 17290-70-9 50mg QQ客服：1413575084
    异橙黄酮 CFN90806 17290-70-9 100mg QQ客服：1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Shanghai Institute of Organic Chemistry (China)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • University of South Australia (Australia)
  • Kazusa DNA Research Institute (Japan)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytochemistry Letters2021, 43:80-87.
  • J Ethnopharmacol.2024, 318:116863.
  • Hortic Res.2023, 10(4):uhad039.
  • Food Res Int.2021, 148:110607.
  • Food Chem.2016, 191:81-90
  • Sustainability2021, 13(23),12981.
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • J. ISSAAS2023, 29(2):36-51.
  • Molecules.2015, 20(10):19172-88
  • Appl Microbiol Biotechnol.2024, 108(1):207.
  • Oncotarget.2017, 9(3):4161-4172
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Theoretical and Experimental Plant Physiology 2022, 34,53-62
  • Chem Biol Interact.2016, 258:59-68
  • Journal of Ginseng Research2021, 3 June.
  • J. Soc. Cosmet. Sci. Korea2021, 47(1):57-63
  • Universite de Bordeaux2017, 2017BORD0867
  • Am J Chin Med.2022, 1-20.
  • Applied Biological Chemistry2022, 71:s13765-022-00743-5.
  • Korean Journal of Pharmacognosy.2020, 51(2):100-106
  • J Anal Methods Chem.2022, 2022:2229500.
  • Asian Journal of Chemistry2014, 26(8):2425
  • Vietnam Journal of Food Control.2022, 5(3):pp.488-497.
  • ...
    • 生物活性
    Description: Isosinensetin shows antioxidant and HIV-1 protease inhibiting activities.
    Targets: HIV
    In vitro:
    Phytomedicine. 2011 Jan 15;18(2-3):189-93.
    Isolation of adenosine, iso-sinensetin and dimethylguanosine with antioxidant and HIV-1 protease inhibiting activities from fruiting bodies of Cordyceps militaris[Pubmed: 20576416 ]
    According to previous studies, a close relationship between oxidative stress and AIDS suggests that antioxidants might play an important role in the treatment of AIDS.
    METHODS AND RESULTS:
    Cordyceps militaris was selected from nine edible mushrooms by assay of inhibition of erythrocyte hemolysis. Macroporous adsorption resin and HPLC were used to purify three micromolecular compounds named L3a, L3b and L3c. L3a was identified to be adenosine with the molecular formula C(10)H(13)N(5)O(4); L3b was 6,7,2',4',5'-pentamethoxyflavone with the molecular formula C(20)H(20)O(7), and L3c was dimethylguanosine with the molecular formula C(12)H(17)N(5)O(5). The compound 6,7,2',4',5'-pentamethoxyflavone was first isolated from C. militaris. The assay of inhibition of HIV-1 protease (HIV-1 PR) was based on the fact that the expression of this enzyme can inhibit the growth of E. coli.
    CONCLUSIONS:
    This is a new screening system for HIV-1 PR inhibitors. Both L3a and L3b showed high inhibition to HIV-1 PR. These compounds could be new anti-HIV-1 PR drugs.
    In vivo:
    Toxicol Appl Pharmacol . 2019 Apr 15;369:49-59.
    Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships[Pubmed: 30790579]
    Abstract Flavonoids are a class of polyphenol antioxygen, despite various known biological activities and therapeutic potential, scattered but not much is known about their interactions with drug transporters. P-glycoprotein (P-gp) as a cellular defense mechanism by effluxing its substrates has been widely investigated. The aim of this study was to investigate the inhibitory effects of 75 flavonoids on P-gp in vitro and in vivo and to illuminate the structure-activity relationships of flavonoids with P-gp. Five flavonoids, including tangeretin, sinensetin, isosinensetin, sciadopitysin and oroxylin A exhibited significant inhibition on P-gp in MDR1-MDCKIIcells, which reduced the P-gp-mediated efflux of paraquat and taxol and consequently increased their cell toxicity. In addition, co-administration of digoxin with five flavonoids increased the AUC0-t of digoxin in different extents in rats, from 19.84% to 81.51%. Molecular docking assays elucidated the inhibitory effect of flavonoids might be related to Pi interactions, but not hydrogen bonds. The pharmacophore model suggested the hydrophobic groups in B benzene ring may play a vital role in the potency of flavonoids inhibition on P-gp. Taken together, our findings would provide the basis for a reliable assessment of the potential risks of flavonoid-containing food/herb-drug interactions in humans. Keywords: Flavonoids; Inhibition; P-glycoprotein; Structure–activity relationships.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6853 mL 13.4264 mL 26.8528 mL 53.7057 mL 67.1321 mL
    5 mM 0.5371 mL 2.6853 mL 5.3706 mL 10.7411 mL 13.4264 mL
    10 mM 0.2685 mL 1.3426 mL 2.6853 mL 5.3706 mL 6.7132 mL
    50 mM 0.0537 mL 0.2685 mL 0.5371 mL 1.0741 mL 1.3426 mL
    100 mM 0.0269 mL 0.1343 mL 0.2685 mL 0.5371 mL 0.6713 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    川陈皮素； 蜜橘黄素； 川皮亭; Nobiletin CFN98726 478-01-3 C21H22O8 = 402.4 20mg QQ客服：1457312923
    3,5,6,7,8,4'-六甲氧基黄酮; 3,5,6,7,8,4'-hexamethoxyflavone CFN91805 34170-18-8 C21H22O8 = 402.4 5mg QQ客服：2056216494
    3,3',4',5,6,7,8-七甲氧基黄酮; 3,3',4',5,6,7,8-heptamethoxyflavone CFN95021 1178-24-1 C22H24O9 = 432.4 10mg QQ客服：3257982914
    4'-羟基黄烷酮; 4'-Hydroxyflavone CFN91544 4143-63-9 C15H10O3 = 238.2 20mg QQ客服：3257982914
    4'-甲氧基黄酮; 4'-Methoxyflavone CFN70361 4143-74-2 C16H12O3 = 252.3 5mg QQ客服：1413575084
    7-羟基-4'-甲氧基黄酮; 7-Hydroxy-4'-methoxyflavone CFN70378 487-24-1 C16H12O4 = 268.3 5mg QQ客服：2056216494
    3',4'-二羟基黄酮; 3',4'-Dihydroxyflavone CFN70360 4143-64-0 C15H10O4 = 254.2 20mg QQ客服：2159513211
    3',4'-二甲氧基黄酮; 3',4'-Dimethoxyflavone CFN70359 4143-62-8 C17H14O4 = 282.3 20mg QQ客服：1413575084
    3',4',7-三羟基黄酮; 7,3',4'-Trihydroxyflavone CFN97786 2150-11-0 C15H10O5 = 270.24 20mg QQ客服：1413575084
    3',4',7,8-四羟基黄酮; 3',4',7,8-Tetrahydroxyflavone CFN70342 3440-24-2 C15H10O6 = 286.2 5mg QQ客服：2056216494

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