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  • 3',4'-二羟基黄酮

    3',4'-Dihydroxyflavone

    3',4'-二羟基黄酮
    产品编号 CFN70360
    CAS编号 4143-64-0
    分子式 = 分子量 C15H10O4 = 254.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The seeds of Cassia occidentalis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3',4'-二羟基黄酮 CFN70360 4143-64-0 10mg QQ客服:2056216494
    3',4'-二羟基黄酮 CFN70360 4143-64-0 20mg QQ客服:2056216494
    3',4'-二羟基黄酮 CFN70360 4143-64-0 50mg QQ客服:2056216494
    3',4'-二羟基黄酮 CFN70360 4143-64-0 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Wroclaw Medical University (Poland)
  • Universidad de La Salle (Mexico)
  • University of Leipzig (Germany)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Sanford Burnham Medical Research Institute (USA)
  • Korea Institute of Oriental Medicine (Korea)
  • Chungnam National University (Korea)
  • University of Wuerzburg (Germany)
  • University of Minnesota (USA)
  • Colorado State University (USA)
  • University of Ioannina (Greece)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Agricultural Research Organization (ARO) (Israel)
  • Universitas Airlangga (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plants (Basel).2020, 9(11):1555.
  • Molecules.2022, 27(13):4227.
  • Plants (Basel).2022, 11(16):2126.
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • Arch Biochem Biophys.2020, 687:108363.
  • Crystals2020, 10(3), 206.
  • J Microbiol Biotechnol.2022, 32(2):141-148.
  • Food Chem Toxicol.2023, 176:113785.
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Key Engineering Materials2022, 931(47-53).
  • Enzyme Microb Technol.2022, 153:109941.
  • Molecules.2022, 27(7):2360.
  • Food Science and Biotechnology2023, 2023:1007
  • J of Apicultural Research2020, 10.1080
  • J Biochem Mol Toxicol.2017, 31(9)
  • Res Rep Urol.2022, 14:313-326.
  • Int J Mol Sci.2017, 18(5)
  • J Ethnopharmacol.2017, 206:73-77
  • J Funct Foods2019, 54:449-456
  • Front Pharmacol.2022, 13:972825.
  • Clin Exp Pharmacol Physiol.2020, doi: 10.1111
  • Int J Mol Sci.2020, 21(24):9369.
  • Acta Agriculturae Scandinavica2015, 381-383
  • ...
  • 生物活性
    Description: 3',4'-Dihydroxyflavone shows anti-inflammatory activity, which might be related to suppression of the proinflammatory MAPK and NF-κB signaling pathways. 3',4'-Dihydroxyflavone can inhibit parasitophorous vacuole formation, modulate glial cell responses, increase NO secretion, and interfere with N. caninum infection and proliferation.
    Targets: MAPK | NO | NF-κB
    In vitro:
    Biomolecules & therapeutics, 2018, 26(2):210-217.
    Synthetic 3',4'-Dihydroxyflavone Exerts Anti-Neuroinflammatory Effects in BV2 Microglia and a Mouse Model.[Reference: WebLink]
    Neuroinflammation is an immune response within the central nervous system against various proinflammatory stimuli. Abnormal activation of this response contributes to neurodegenerative diseases such as Parkinson disease, Alzheimer's disease, and Huntington disease. Therefore, pharmacologic modulation of abnormal neuroinflammation is thought to be a promising approach to amelioration of neurodegenerative diseases.
    METHODS AND RESULTS:
    In this study, we evaluated the synthetic flavone derivative 3',4'-dihydroxyflavone, investigating its anti-neuroinflammatory activity in BV2 microglial cells and in a mouse model. In BV2 microglial cells, 3',4'-dihydroxyflavone successfully inhibited production of chemokines such as nitric oxide and prostaglandin E2and proinflammatory cytokines such as tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 in BV2 microglia. It also inhibited phosphorylation of mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB activation. This indicates that the anti-inflammatory activities of 3',4'-dihydroxyflavone might be related to suppression of the proinflammatory MAPK and NF-κB signaling pathways. Similar anti-neuroinflammatory activities of the compound were observed in the mouse model.
    CONCLUSIONS:
    These findings suggest that 3',4'-dihydroxyflavone is a potential drug candidate for the treatment of microglia-related neuroinflammatory diseases.
    Journal of Microbiology & Biotechnology, 2010, 20(9):1359-1366.
    Characterization of an O-methyltransferase from Streptomyces avermitilis MA-4680.[Reference: WebLink]
    A search of the Streptomyces avermitilis genome reveals that its closest homologs are several O-methyltransferases. Among them, one gene (viz., saomt5) was cloned into the pET-15b expression vector by polymerase chain reaction using sequence-specific oligonucleotide primers.
    METHODS AND RESULTS:
    Biochemical characterization with the recombinant protein showed that SaOMT5 was S-adenosyl-L-methionine-dependent Omethyltransferase. Several compounds were tested as substrates of SaOMT5. As a result, SaOMT5 catalyzed Omethylation of flavonoids such as 6,7-dihydroxyflavone, 2',3'-dihydroxyflavone, 3',4'-dihydroxyflavone, quercetin, and 7,8-dihydroxyflavone, and phenolic compounds such as caffeic acid and caffeoyl Co-A.
    CONCLUSIONS:
    These reaction products were analyzed by TLC, HPLC, LC/MS, and NMR spectroscopy. In addition, SaOMT5 could convert phenolic compounds containing ortho-dihydroxy groups into Omethylated compounds, and 6,7-dihydroxyflavone was known to be the best substrate. SaOMT5 converted 6,7- dihydroxyflavone into 6-hydroxy-7-methoxyflavone and 7-hydroxy-6-methoxyflavone, and caffeic acid into ferulic acid and isoferulic acid, respectively. Moreover, SaOMT5 turned out to be a Mg2+-dependent OMT, and the effect of Mg2+ ion on its activity was five times greater than those of Ca2+, Fe2+, and Cu2+ ions, EDTA, and metal-free medium.
    The Korean Journal of Parasitology, 2014, 52(6):613-619.
    Flavonoids modulate the proliferation of Neospora caninum in glial cell primary cultures.[Reference: WebLink]
    Neospora caninum (Apicomplexa; Sarcocystidae) is a protozoan that causes abortion in cattle, horses, sheep, and dogs as well as neurological and dermatological diseases in dogs. In the central nervous system of dogs infected with N. caninum, cysts were detected that exhibited gliosis and meningitis. Flavonoids are polyphenolic compounds that exhibit antibacterial, antiparasitic, antifungal, and antiviral properties.
    METHODS AND RESULTS:
    In this study, we investigated the effects of flavonoids in a well-established in vitro model of N. caninum infection in glial cell cultures. Glial cells were treated individually with 10 different flavonoids, and a subset of cultures was also infected with the NC-1 strain of N. caninum. All of the flavonoids tested induced an increase in the metabolism of glial cells and many of them increased nitrite levels in cultures infected with NC-1 compared to controls and uninfected cultures. Among the flavonoids tested, 3',4'-dihydroxyflavone, 3',4',5,7-tetrahydroxyflavone (luteolin), and 3,3',4',5,6-pentahydroxyflavone (quercetin), also inhibited parasitophorous vacuole formation.
    CONCLUSIONS:
    Taken together, our findings show that flavonoids modulate glial cell responses, increase NO secretion, and interfere with N. caninum infection and proliferation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9339 mL 19.6696 mL 39.3391 mL 78.6782 mL 98.3478 mL
    5 mM 0.7868 mL 3.9339 mL 7.8678 mL 15.7356 mL 19.6696 mL
    10 mM 0.3934 mL 1.967 mL 3.9339 mL 7.8678 mL 9.8348 mL
    50 mM 0.0787 mL 0.3934 mL 0.7868 mL 1.5736 mL 1.967 mL
    100 mM 0.0393 mL 0.1967 mL 0.3934 mL 0.7868 mL 0.9835 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4',5,8-三羟基-3',6,7-三甲氧基黄酮; Isothymonin CFN92436 99615-01-7 C18H16O8 = 360.3 5mg QQ客服:215959384
    5-羟基-7,3',4'-三甲氧基黄酮; 5-Hydroxy-3',4',7-trimethoxyflavone CFN98361 29080-58-8 C18H16O6 = 328.3 20mg QQ客服:1457312923
    异泽兰黄素; 泽兰林素; Eupatilin CFN90190 22368-21-4 C18H16O7 = 344.31 20mg QQ客服:3257982914
    5-去甲基甜橙黄酮; 5-Demethylsinensetin CFN95415 21763-80-4 C19H18O7 = 358.34 10mg QQ客服:1413575084
    甜橙黄酮; 5,6,7,3',4'-五甲氧基黄酮; Sinensetin CFN99599 2306-27-6 C20H20O7 = 372.37 20mg QQ客服:1413575084
    异橙黄酮; Isosinensetin CFN90806 17290-70-9 C20H20O7 = 372.4 20mg QQ客服:1413575084
    去甲基川陈皮素; 5-O-Demethylnobiletin CFN90921 2174-59-6 C20H20O8 = 388.4 20mg QQ客服:3257982914
    川陈皮素; 蜜橘黄素; 川皮亭; Nobiletin CFN98726 478-01-3 C21H22O8 = 402.4 20mg QQ客服:1413575084
    3,5,6,7,8,4'-六甲氧基黄酮; 3,5,6,7,8,4'-hexamethoxyflavone CFN91805 34170-18-8 C21H22O8 = 402.4 5mg QQ客服:1413575084
    3,3',4',5,6,7,8-七甲氧基黄酮; 3,3',4',5,6,7,8-heptamethoxyflavone CFN95021 1178-24-1 C22H24O9 = 432.4 10mg QQ客服:2056216494

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