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  • 2',6'-二羟基-4,4'-二甲氧基二氢查耳酮

    2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone

    2',6'-二羟基-4,4'-二甲氧基二氢查耳酮
    产品编号 CFN70345
    CAS编号 35241-54-4
    分子式 = 分子量 C17H18O5 = 302.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The herbs of Cedrus deodara
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2',6'-二羟基-4,4'-二甲氧基二氢查耳酮 CFN70345 35241-54-4 1mg QQ客服:2056216494
    2',6'-二羟基-4,4'-二甲氧基二氢查耳酮 CFN70345 35241-54-4 5mg QQ客服:2056216494
    2',6'-二羟基-4,4'-二甲氧基二氢查耳酮 CFN70345 35241-54-4 10mg QQ客服:2056216494
    2',6'-二羟基-4,4'-二甲氧基二氢查耳酮 CFN70345 35241-54-4 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Preprints2017, 2017120176
  • Int Immunopharmacol.2023, 125:111175.
  • Journal of Ginseng Research2021, 3 June.
  • J Mol Med (Berl).2018, 96(7):661-672
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
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  • Research Square2021, 10.21203.
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  • Sci Rep. 2017, 17332(7)
  • Korean J Dent Mater.2018, 45(2):139-146
  • VNU Journal of Science2023, No. 20.
  • Int Immunopharmacol.2019, 71:361-371
  • South African J of Plant&Soil2018, 29-32
  • Plants (Basel).2021, 10(5):951.
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  • J Nat Prod.2021, 84(9):2544-2553.
  • bioRxiv - Molecular Biology2023, 535548.
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  • ...
  • 生物活性
    Description: 2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone can markedly augment TRAIL-induced apoptosis and cytotoxicity in LNCaP cells.
    In vitro:
    Molecules (Basel, Switzerland), 04 Aug 2010, 15(8):5336-5353.
    Chalcones and dihydrochalcones augment TRAIL-mediated apoptosis in prostate cancer cells.[Reference: WebLink]
    Chalcones and dihydrochalcones exhibit chemopreventive and antitumor activity. TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a natural endogenous anticancer agent. We examined the cytotoxic and apoptotic effect of chalcones and dihydrochalcones on TRAIL-mediated apoptosis in LNCaP prostate cancer cells.
    METHODS AND RESULTS:
    The cytotoxicity was evaluated by the MTT and LDH assays. The apoptosis was detected using annexin V-FITC by flow cytometry and fluorescence microscopy. The DeltaPsim was evaluated using DePsipher staining by fluorescence microscopy.
    CONCLUSIONS:
    Our study showed that two tested chalcones (chalcone and 2',6'dihydroxy-4'-methoxychalcone) and three dihydrochalcones (2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone, 2',6'-dihydroxy-4'-methoxydihydro- chalcone, and 2',4',6'-trihydroxydihydrochalcone, called phloretin) markedly augmented TRAIL-induced apoptosis and cytotoxicity in LNCaP cells and confirmed the significant role of chalcones in chemoprevention of prostate cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.308 mL 16.5399 mL 33.0797 mL 66.1594 mL 82.6993 mL
    5 mM 0.6616 mL 3.308 mL 6.6159 mL 13.2319 mL 16.5399 mL
    10 mM 0.3308 mL 1.654 mL 3.308 mL 6.6159 mL 8.2699 mL
    50 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.3232 mL 1.654 mL
    100 mM 0.0331 mL 0.1654 mL 0.3308 mL 0.6616 mL 0.827 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4,4'-二羟基-2',6'-二甲氧基查耳酮 ; 2'-O-Methylhelichrysetin CFN97920 123316-64-3 C17H16O5 = 300.3 5mg QQ客服:1457312923
    黄卡瓦胡椒素C; Flavokawain C CFN90741 56798-34-6 C17H16O5 = 300.3 10mg QQ客服:2056216494
    黄卡瓦胡椒素A; 2'- 羟基-4,4',6'-三甲氧基查耳酮; Flavokawain A CFN98446 3420-72-2 C18H18O5 = 314.3 10mg QQ客服:2159513211
    2',4',6',4-四甲氧基查耳酮; 2',4',6',4-Tetramethoxychalcone CFN91683 94103-36-3 C19H20O5 = 328.4 5mg QQ客服:1413575084
    2',4'-二羟基-2,3',6'- 三甲氧基查尔酮; 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone CFN99015 100079-39-8 C18H18O6 = 330.3 5mg QQ客服:2159513211
    3'-Methylflavokawin; 3'-Methylflavokawin CFN96084 1044743-35-2 C18H18O5 = 314.3 5mg QQ客服:1457312923
    3'-甲基-2',4'-二羟基-4,6'-二甲氧基查耳酮 ; 3'-Methyl-4-O-methylhelichrysetin CFN96164 109471-13-8 C18H18O5 = 314.3 5mg QQ客服:215959384
    4,4'-二甲氧基查耳酮; 4,4'-Dimethoxychalcone CFN70472 2373-89-9 C17H16O3 = 268.3 5mg QQ客服:3257982914
    异甘草素; 4,2',4'-三羟基查耳酮; Isoliquiritigenin CFN97542 961-29-5 C15H12O4 = 256.3 20mg QQ客服:3257982914
    2''-O-甲基异甘草苷元; 4,4'-二羟基-2'-甲氧基查耳酮; 2'-O-Methylisoliquiritigenin CFN98832 51828-10-5 C16H14O4 = 270.3 5mg QQ客服:2056216494

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