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  • 根皮素

    Phloretin

    根皮素
    产品编号 CFN97040
    CAS编号 60-82-2
    分子式 = 分子量 C15H14O5 = 274.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The peels of apple.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    根皮素 CFN97040 60-82-2 10mg QQ客服:3257982914
    根皮素 CFN97040 60-82-2 20mg QQ客服:3257982914
    根皮素 CFN97040 60-82-2 50mg QQ客服:3257982914
    根皮素 CFN97040 60-82-2 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Research Council of Canada (Canada)
  • Universidad de La Salle (Mexico)
  • MTT Agrifood Research Finland (Finland)
  • University of Minnesota (USA)
  • University of Bordeaux (France)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Donald Danforth Plant Science Center (USA)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • University of Sao Paulo (Brazil)
  • Auburn University (USA)
  • Universite Libre de Bruxelles (Belgium)
  • University of Brasilia (Brazil)
  • Worcester Polytechnic Institute (USA)
  • China Medical University (Taiwan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2021, 360:130063.
  • Appl. Sci. 2021, 11(8),3437.
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Molecules.2023, 28(3):958.
  • Planta Med.2019, 85(3):217-224
  • Evid Based Complement Alternat Med.2015, 2015:165457
  • Molecules.2022, 27(21):7643.
  • Journal of Analytical Chemistry2017, 854-861
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Internoational J of Toxicology2020, 10.1177.
  • Eur J Pharmacol.2018, 832:96-103
  • J Sep Sci.2022, 45(18):3556-3566.
  • Nutrients.2022, 14(16):3393.
  • Exp Ther Med.2019, 18(6):4388-4396
  • Cancers (Basel).2023, 15(1):37.
  • Food Chem.2018, 262:78-85
  • Journal of Oil Palm Research2019, 31(2):238-247
  • Food Analytical Methods2020, 1-10
  • Phytomedicine Plus2022, 2(1):100207.
  • J Ethnopharmacol.2020, 254:112733.
  • Antioxidants (Basel).2021, 10(11): 1802.
  • ...
  • 生物活性
    Description: Phloretin may potentially be an immunomodulator by impairing the activation and function of DCs, it is effective in preventing estrogen deficiency-induced osteoclastogenic resorption. Phloretin has antimicrobial activity against the Gram negative bacteria Salmonella typhimurium ATCC 13311. It has a wide spectrum of targets including ASK-1-MAPK, Smac, capase.
    Targets: NF-kB | Bcl-2/Bax | Caspase | JNK | p38MAPK | ERK | ASK | TLR | ROS | gp120/CD4 | IFN-γ
    In vitro:
    Food Chem. 2014 Oct 1;160:292-7.
    Biochemical and antimicrobial activity of phloretin and its glycosilated derivatives present in apple and kumquat.[Pubmed: 24799241]
    Phloretin and its glycosylated derivatives (phlorizin and phloretin 3',5'-di-C-glucoside) are dihydrochalcones that have many interesting biological properties.
    METHODS AND RESULTS:
    The results obtained showed that the dihydrochalcones are able to inhibit growth of Gram positive bacteria, in particular Staphylococcus aureus ATCC 6538, Listeria monocytogenes ATCC 13932 and methicillin-resistant S. aureus clinical strains. Moreover, phloretin is active also against the Gram negative bacteria Salmonella typhimurium ATCC 13311.
    CONCLUSIONS:
    The determination of the enzymatic activity of key metabolic enzymes allowed us to shed some light on the biochemical mechanism of aglycon cell growth inhibition, showing as it remarkably influences the energetic metabolism of S. aureus. In addition, structure/activity determinations highlighted that the presence of a glycosyl moiety bound to the chalcone structure dramatically decreases the antimicrobial activity of phloretin.
    In vivo:
    Phytomedicine. 2014 Sep 15;21(10):1208-15.
    Phloretin promotes osteoclast apoptosis in murine macrophages and inhibits estrogen deficiency-induced osteoporosis in mice. [Pubmed: 24932975]
    Bone-remodeling imbalance induced by increased osteoclast formation and bone resorption is known to cause skeletal diseases such as osteoporosis. The reduction of estrogen levels at menopause is one of the strongest risk factors developing postmenopausal osteoporosis.
    METHODS AND RESULTS:
    This study investigated osteoprotective effects of the dihydrochalcone phloretin found in apple tree leaves on bone loss in ovariectomized (OVX) C57BL/6 female mice as a model for postmenopausal osteoporosis. OVX demoted bone mineral density (BMD) of mouse femurs, reduced serum 17β-estradiol level and enhanced serum receptor activator of NF-κB ligand (RANKL)/osteoprotegerin ratio with uterine atrophy. Oral administration of 10 mg/kg phloretin to OVX mice for 8 weeks improved such effects, compared to sham-operated mice. Phloretin attenuated TRAP activity and cellular expression of β3 integrin and carbonic anhydrase II augmented in femoral bone tissues of OVX mice. This study further examined that osteogenic activity of phloretin in RANKL-differentiated Raw 264.7 macrophages into mature osteoclasts. Phloretin at 1-20 μM stimulated Smac expression and capase-3 activation concurrently with nuclear fragmentation of multi-nucleated osteoclasts, indicating that this compound promoted osteoclast apoptosis. Consistently, phloretin enhanced bcl-2 induction but diminished bax expression. Furthermore, phloretin activated ASK-1-diverged JNK and p38 MAPK signaling pathways in mature osteoclasts, whereas it dose-dependently inhibited the RANKL-stimulated activation of ERK.
    CONCLUSIONS:
    Therefore, phloretin manipulated ASK-1-MAPK signal transduction leading to transcription of apoptotic genes. Phloretin was effective in preventing estrogen deficiency-induced osteoclastogenic resorption.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6456 mL 18.2282 mL 36.4564 mL 72.9129 mL 91.1411 mL
    5 mM 0.7291 mL 3.6456 mL 7.2913 mL 14.5826 mL 18.2282 mL
    10 mM 0.3646 mL 1.8228 mL 3.6456 mL 7.2913 mL 9.1141 mL
    50 mM 0.0729 mL 0.3646 mL 0.7291 mL 1.4583 mL 1.8228 mL
    100 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.7291 mL 0.9114 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    黄卡瓦胡椒素A; 2'- 羟基-4,4',6'-三甲氧基查耳酮; Flavokawain A CFN98446 3420-72-2 C18H18O5 = 314.3 10mg QQ客服:3257982914
    2',4',6',4-四甲氧基查耳酮; 2',4',6',4-Tetramethoxychalcone CFN91683 94103-36-3 C19H20O5 = 328.4 5mg QQ客服:215959384
    2',4'-二羟基-2,3',6'- 三甲氧基查尔酮; 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone CFN99015 100079-39-8 C18H18O6 = 330.3 5mg QQ客服:215959384
    3'-Methylflavokawin; 3'-Methylflavokawin CFN96084 1044743-35-2 C18H18O5 = 314.3 5mg QQ客服:2159513211
    3'-甲基-2',4'-二羟基-4,6'-二甲氧基查耳酮 ; 3'-Methyl-4-O-methylhelichrysetin CFN96164 109471-13-8 C18H18O5 = 314.3 5mg QQ客服:3257982914
    4,4'-二甲氧基查耳酮; 4,4'-Dimethoxychalcone CFN70472 2373-89-9 C17H16O3 = 268.3 5mg QQ客服:1413575084
    异甘草素; 4,2',4'-三羟基查耳酮; Isoliquiritigenin CFN97542 961-29-5 C15H12O4 = 256.3 20mg QQ客服:1413575084
    2''-O-甲基异甘草苷元; 4,4'-二羟基-2'-甲氧基查耳酮; 2'-O-Methylisoliquiritigenin CFN98832 51828-10-5 C16H14O4 = 270.3 5mg QQ客服:3257982914
    3-去氧苏木查耳酮; 3-Deoxysappanchalcone CFN92833 112408-67-0 C16H14O4 = 270.3 5mg QQ客服:2159513211
    4,2'-Dihydroxy-4'-methoxychalcone ; 4,2'-Dihydroxy-4'-methoxychalcone CFN89427 63529-06-6 C16H14O4 = 270.28 5mg QQ客服:2056216494

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