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  • 4'-O-甲基根皮素

    Asebogenin

    4'-O-甲基根皮素
    产品编号 CFN96928
    CAS编号 520-42-3
    分子式 = 分子量 C16H16O5 = 288.29
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The leaves of Pieris japonica.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4'-O-甲基根皮素 CFN96928 520-42-3 1mg QQ客服:1457312923
    4'-O-甲基根皮素 CFN96928 520-42-3 5mg QQ客服:1457312923
    4'-O-甲基根皮素 CFN96928 520-42-3 10mg QQ客服:1457312923
    4'-O-甲基根皮素 CFN96928 520-42-3 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Leipzig (Germany)
  • Medical University of Gdansk (Poland)
  • Aveiro University (Portugal)
  • Universit?t Basel (Switzerland)
  • University of Dicle (Turkey)
  • Max-Planck-Insitut (Germany)
  • The Institute of Cancer Research (United Kingdom)
  • Ain Shams University (Egypt)
  • Calcutta University (India)
  • Technical University of Denmark (Denmark)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Copenhagen University (Denmark)
  • Uniwersytet Gdański (Poland)
  • Charles Sturt University (Denmark)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2022, 23(5):2796.
  • Antioxidants (Basel).2021, 10(10):1620.
  • Ind Crops Prod.2014, 62:173-178
  • Phytomedicine.2020, 79, 153351
  • J Agric Food Chem.2017, 65(13):2670-2676
  • J of Physics Conference Series2019, 1349(1)
  • Plants (Basel).2020, 9(11):1535.
  • Inflammation.2022, 45(6):2529-2543.
  • Synthetic and Systems Biotechnology2023, j.synbio.
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • J Ethnopharmacol.2020, 249:112396
  • J Cosmet Dermatol.2022, 21(1):396-402.
  • Journal of Functional Foods2022, 98:105271.
  • Applied Biological Chemistry2023, 66:85.
  • Evid Based Complement Alternat Med.2021, 2021:8707280.
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • Functional Ecology2020, doi: 10.1111.
  • J Biol Chem.2021, 297(6):101362.
  • Nutrients2022, 14(14)2929
  • FEBS Lett.2015, 589(1):182-7
  • Molecules.2018, 23(9):E2121
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Phytother Res.2019, 33(3):676-689
  • ...
  • 生物活性
    Description: Asebogenin has anti-bacterial activity, it shows inhibitory activity against S. aureus and methicillin-resistant S. aureus (IC50 of 10 and 4.5 micrograms/ml, respectively); it shows antiplasmodial activities against both a chloroquine-sensitive and a resistant strain of Plasmodium falciparum. Asebogenin can inhibit the proliferation of murine B cells.
    Targets: ATPase | Potassium Channel | Antifection
    In vitro:
    J Ethnopharmacol. 2010 Apr 21;128(3):583-9.
    Anti-secretory, anti-inflammatory and anti-Helicobacter pylori activities of several fractions isolated from Piper carpunya Ruiz & Pav.[Pubmed: 20152892]

    METHODS AND RESULTS:
    Eight fractions showed inhibition of MPO enzyme (F I-IV, X, XII, XIV and XV). The highest inhibition was observed with F XIV (50microg/mL, 60.9%, p<0.001). F X and XII were the most active ones, inhibiting the gastric H(+), K(+)-ATPase activity with IC(50) values equal to 22.3microg/mL and 28.1microg/mL, respectively. All fractions, except F XV, presented detectable anti-Helicobacter pylori activity, with a diameter of inhibition zones ranging from 11mm up to 50mm. The best anti-Helicobacter pylori activity was obtained with F III and V. Both fractions killed Helicobacter pylori with lowest concentration values, about 6.25mug/mL.
    CONCLUSIONS:
    Sixteen pure compounds were isolated, five of them are flavonoids that possess strong anti-oxidant and free radical scavenging activity, e.g. vitexin, isovitexin, and rhamnopyranosylvitexin. Terpenoids like sitosterol, stigmasterol and phytol, which have shown gastroprotective activity, and dihydrochalcones, like Asebogenin, with anti-bacterial activity, were also isolated. Furthermore, the rare neolignan 1, that is a DNA polymerase beta lyase inhibitor, and (6S, 9S)-roseoside, that shows strong anti-bacterial activity, were isolated, for the first time, from the genus Piper.
    Planta Med. 2001 Mar;67(2):186-8.
    Dihydrochalcones from Piper longicaudatum.[Pubmed: 11301876 ]

    METHODS AND RESULTS:
    Bioactivity-guided fractionation of an ethanolic extract of the leaves and twigs of Piper longicaudatum Trelease & Yunker (Piperaceae) resulted in the isolation of one new (1) and three known (2-4) dihydrochalcones. The known compounds are: 2',6'-dihydroxy-4'-methoxydihydrochalcone (2), 2',6',4-trihydroxy-4'-methoxydihydrochalcone (asebogenin) (3), and 2'-hydroxy-4'-methoxy-2'-[1-hydroxy-1-methylethyl]-2",3"-dihy- drofurano[4",5":5',6"]-3"-[2-hydroxy-5-methoxycarbonylphe- nyl]dihydrochalcone (piperaduncin B) (4). The new compound is 2'-hydroxy-4'-methoxy-2"-[2-hydroxy-5-methoxycarbonyl- phenyl]-furano[4",5":5',6']-dihydrochalcone (longicaudatin) (1).
    CONCLUSIONS:
    Compounds 1-4 were tested for antibacterial activity against S. aureus and methicillin-resistant S. aureus (MRSA); only compound 3 showed inhibitory activity (IC50 of 10 and 4.5 micrograms/ml, respectively).
    Trop Med Int Health. 1999 Sep;4(9):611-5.
    The in vitro antiplasmodial activities of 14 plant species traditionally used in Central America for the treatment of malaria or fever were evaluated. Lipophilic extracts of Piper hispidum, Siparuna andina, S. pauciflora, S. tonduziana, and Xylopia cf. fr[Pubmed: 10540301]

    METHODS AND RESULTS:
    The in vitro antiplasmodial activities of 14 plant species traditionally used in Central America for the treatment of malaria or fever were evaluated. Lipophilic extracts of Piper hispidum, Siparuna andina, S. pauciflora, S. tonduziana, and Xylopia cf. frutescens, proved to be active against both a chloroquine-sensitive and a resistant strain of Plasmodium falciparum. IC50 values ranged between 3.0 microg/ml and 21.9 microg/ml; however, moderate cytotoxicity of active extracts was observed.
    CONCLUSIONS:
    Bioactivity-guided fractionation of Piper hispidum yielded 2',4, 6'-trihydroxy-4'-methoxydihydrochalcone (asebogenin) as an active compound.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4687 mL 17.3436 mL 34.6873 mL 69.3746 mL 86.7182 mL
    5 mM 0.6937 mL 3.4687 mL 6.9375 mL 13.8749 mL 17.3436 mL
    10 mM 0.3469 mL 1.7344 mL 3.4687 mL 6.9375 mL 8.6718 mL
    50 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.3875 mL 1.7344 mL
    100 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.6937 mL 0.8672 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4,4'-二甲氧基查耳酮; 4,4'-Dimethoxychalcone CFN70472 2373-89-9 C17H16O3 = 268.3 5mg QQ客服:1413575084
    异甘草素; 4,2',4'-三羟基查耳酮; Isoliquiritigenin CFN97542 961-29-5 C15H12O4 = 256.3 20mg QQ客服:1457312923
    2''-O-甲基异甘草苷元; 4,4'-二羟基-2'-甲氧基查耳酮; 2'-O-Methylisoliquiritigenin CFN98832 51828-10-5 C16H14O4 = 270.3 5mg QQ客服:3257982914
    3-去氧苏木查耳酮; 3-Deoxysappanchalcone CFN92833 112408-67-0 C16H14O4 = 270.3 5mg QQ客服:2159513211
    4,2'-Dihydroxy-4'-methoxychalcone ; 4,2'-Dihydroxy-4'-methoxychalcone CFN89427 63529-06-6 C16H14O4 = 270.28 5mg QQ客服:2056216494
    根皮素; Phloretin CFN97040 60-82-2 C15H14O5 = 274.3 20mg QQ客服:2056216494
    4'-O-甲基根皮素 ; Asebogenin CFN96928 520-42-3 C16H16O5 = 288.29 5mg QQ客服:1457312923
    2',6'-二羟基-4,4'-二甲氧基二氢查耳酮; 2',6'-Dihydroxy 4',4-dimethoxydihydrochalcone CFN70345 35241-54-4 C17H18O5 = 302.3 5mg QQ客服:215959384
    2-甲氧基根皮素; 2'-O-Methylphloretin (4,2',4'-Trihydroxy-6'-methoxydihydrochalcone) CFN91680 111316-17-7 C16H16O5 = 288.3 5mg QQ客服:2159513211
    4,2',4'-三羟基-6'-甲氧基查耳酮; Helichrysetin CFN97065 62014-87-3 C16H14O5 = 286.3 5mg QQ客服:2159513211

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