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  • 3-去氧苏木查耳酮

    3-Deoxysappanchalcone

    3-去氧苏木查耳酮
    产品编号 CFN92833
    CAS编号 112408-67-0
    分子式 = 分子量 C16H14O4 = 270.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The heartwoods of Caesalpinia sappan Linn
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-去氧苏木查耳酮 CFN92833 112408-67-0 1mg QQ客服:215959384
    3-去氧苏木查耳酮 CFN92833 112408-67-0 5mg QQ客服:215959384
    3-去氧苏木查耳酮 CFN92833 112408-67-0 10mg QQ客服:215959384
    3-去氧苏木查耳酮 CFN92833 112408-67-0 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kamphaengphet Rajabhat University (Thailand)
  • Chang Gung University (Taiwan)
  • Kyoto University (Japan)
  • University of Illinois at Chicago (USA)
  • Melbourne University (Australia)
  • Kazusa DNA Research Institute (Japan)
  • Mahidol University (Thailand)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • China Medical University (Taiwan)
  • Chungnam National University (Korea)
  • National Hellenic Research Foundation (Greece)
  • Medizinische Universit?t Wien (Austria)
  • Institute of Chinese Materia Medica (China)
  • Shanghai University of TCM (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Med Rep.2022, 26(4):299.
  • Nutraceuticals2022, 2(3),150-161
  • Phytother Res.2020, 34(4):788-795.
  • Plant Sci.2020, 301:110656.
  • J Anal Toxicol.2021, bkab015.
  • Molecules.2017, 22(2)
  • Food Analytical Methods2017, 10:3225-3234
  • J Separation Science & Technology2016, 51:1579-1588
  • Microbiol. Biotechnol. Lett.2022, 50(2): 193-201.
  • Toxicol In Vitro.2022, 81:105346.
  • Molecules.2015, 20(10):19172-88
  • J Chem Inf Model.2021, 61(11):5708-5718.
  • Food Chemistry: X.2022, 2022.100270
  • Applied Biological Chemistry2022, 65(12)
  • J Ethnopharmacol.2019, 228:132-141
  • Front Immunol.2018, 9:2655
  • Int J Mol Sci.2020, 21(22):8816.
  • ACS Chem Biol.2019, 14(5):873-881
  • In Vitro Cellular & Developmental Biology - Plant 2021, 57:874–882.
  • JLiquid Chromatography & Related Tech.2021, 10826076.
  • Medicina (Kaunas).2020, 56(12):685.
  • Korean Journal of Pharmacognosy2017, 48(4):320-328
  • Exp Neurobiol.2018, 27(3):200-209
  • ...
  • 生物活性
    Description: 3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level. 3-Deoxysappanchalcone has anti-inflammatory, and anti-influenza virus activities, the mechanism involved anti-apoptosis and anti-inflammation activities in vitro. It has inhibitory activity on MMP-9 expression and production in TNF-α-treated cells, is mediated by the suppression of AP-1 and NF-κB activation.
    Targets: HO-1 | mTOR | Akt | NO | IL Receptor | TNF-α | AP-1 | NF-kB | MMP(e.g.TIMP)
    In vitro:
    Planta Med. 2012 Jun;78(10):968-73.
    The protective effect of 3-deoxysappanchalcone on in vitro influenza virus-induced apoptosis and inflammation.[Pubmed: 22648377]
    Influenza virus is one of the most important causes of acute respiratory disease. Viral infection and viral replication activate multiple cell signalling pathways. Apoptosis of infected cells and immune response against viral replication, which are generally considered to be protective mechanisms, are also probably mediated by viruses, which lead to severe health problems. We previously reported that 3-deoxysappanchalcone (3-DSC), a compound that is isolated from Caesalpinia sappan, exhibited in vitro anti-influenza activity.
    METHODS AND RESULTS:
    In the present study, we further identified that 3-DSC inhibited viral genomic replication and transcription only at a relatively high concentration. We then evaluated the effect of 3-DSC on the regulation of virus-induced cellular apoptosis. 3-DSC ameliorated virus-induced DNA fragmentation in a concentration-dependent manner, which tends to be a consequence of its inhibition of upstream caspase activation. 3-DSC also protected host cells against influenza-induced inflammation by suppressing CCL5 and CXCL10 secretions in endothelial cells and reducing the production of IL-6 and IL-1β in monocytes/macrophages.
    CONCLUSIONS:
    In conclusion, our results demonstrate that anti-influenza virus mechanisms of 3-DSC involved anti-apoptosis and anti-inflammation activities in vitro. Moreover, 3-DSC could be a promising drug candidate for influenza treatment.
    In vivo:
    Int Immunopharmacol . 2014 Oct;22(2):420-6.
    The anti-inflammatory effect of 3-deoxysappanchalcone is mediated by inducing heme oxygenase-1 via activating the AKT/mTOR pathway in murine macrophages[Pubmed: 25091623]
    Abstract 3-Deoxysappanchalcone (3-DSC), isolated from Caesalpinia sappan (Leguminosae), is a chalcone that exerts a variety of pharmacological activities. In the present study, we demonstrated that 3-DSC exerts anti-inflammatory activity in murine macrophages by inducing heme oxygenase-1 (HO-1) expression at the translational level. Treatment of RAW264.7 cells with 3-DSC induced HO-1 protein expression in a dose- and time-dependent manner without affecting HO-1 mRNA expression. Mitogen-activated protein kinase inhibitors or actinomycin D, a transcriptional inhibitor, did not block 3-DSC-mediated HO-1 induction. However, 3-DSC-mediated HO-1 induction was completely blocked by treatment with cycloheximide, a translational inhibitor, or rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR). Strikingly, 3-DSC increased the phosphorylation level of mTOR downstream target molecules such as eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) and S6 kinase 1 (S6K1), as well as AKT in a dose- and time-dependent manner, suggesting that the 3-DSC induces HO-1 expression by activating the AKT/mTOR pathway. Consistent with the notion that HO-1 has anti-inflammatory properties, 3-DSC inhibited the production of nitric oxide (NO) and interleukin (IL)-6 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Inhibition of HO-1 activity by treatment with tin protoporphyrin IX, a specific HO-1 inhibitor, abrogated the inhibitory effects of 3-DSC on the production of NO and IL-6 in LPS-stimulated RAW264.7 cells. Taken together, 3-DSC may be an effective HO-1 inducer at the translational level that has anti-inflammatory effects, and a valuable compound for modulating inflammatory conditions. Keywords: 3-Deoxysappanchalcone; Anti-inflammatory effect; Heme oxygenase-1; Translation; mTOR.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.6996 mL 18.498 mL 36.9959 mL 73.9919 mL 92.4898 mL
    5 mM 0.7399 mL 3.6996 mL 7.3992 mL 14.7984 mL 18.498 mL
    10 mM 0.37 mL 1.8498 mL 3.6996 mL 7.3992 mL 9.249 mL
    50 mM 0.074 mL 0.37 mL 0.7399 mL 1.4798 mL 1.8498 mL
    100 mM 0.037 mL 0.185 mL 0.37 mL 0.7399 mL 0.9249 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2',4'-二羟基-4,6'-二甲氧基二氢查尔酮; 2,4-Dihydroxy-4,6-dimethoxydihydrochalcone CFN97962 75679-58-2 C17H18O5 = 302.3 5mg QQ客服:215959384
    2',6'-二羟基-4,4'-二甲氧基查耳酮; 2',6'-Dihydroxy-4,4'-dimethoxychalcone CFN70304 20621-49-2 C17H16O5 = 300.3 5mg QQ客服:2159513211
    2',4'-二羟基-4,6'-二甲氧基查耳酮; 4-O-Methylhelichrysetin CFN96080 56121-44-9 C17H16O5 = 300.3 5mg QQ客服:215959384
    4,4'-二羟基-2',6'-二甲氧基查耳酮 ; 2'-O-Methylhelichrysetin CFN97920 123316-64-3 C17H16O5 = 300.3 5mg QQ客服:2056216494
    黄卡瓦胡椒素C; Flavokawain C CFN90741 56798-34-6 C17H16O5 = 300.3 10mg QQ客服:3257982914
    黄卡瓦胡椒素A; 2'- 羟基-4,4',6'-三甲氧基查耳酮; Flavokawain A CFN98446 3420-72-2 C18H18O5 = 314.3 10mg QQ客服:1413575084
    2',4',6',4-四甲氧基查耳酮; 2',4',6',4-Tetramethoxychalcone CFN91683 94103-36-3 C19H20O5 = 328.4 5mg QQ客服:1457312923
    2',4'-二羟基-2,3',6'- 三甲氧基查尔酮; 2',4'-Dihydroxy-2,3',6'-trimethoxychalcone CFN99015 100079-39-8 C18H18O6 = 330.3 5mg QQ客服:1457312923
    3'-Methylflavokawin; 3'-Methylflavokawin CFN96084 1044743-35-2 C18H18O5 = 314.3 5mg QQ客服:2056216494
    3'-甲基-2',4'-二羟基-4,6'-二甲氧基查耳酮 ; 3'-Methyl-4-O-methylhelichrysetin CFN96164 109471-13-8 C18H18O5 = 314.3 5mg QQ客服:1457312923

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