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  • 高车前素

    Hispidulin

    高车前素
    产品编号 CFN99491
    CAS编号 1447-88-7
    分子式 = 分子量 C16H12O6 = 300.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Ambrosia artemisiifolia Linn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    高车前素 CFN99491 1447-88-7 10mg QQ客服:215959384
    高车前素 CFN99491 1447-88-7 20mg QQ客服:215959384
    高车前素 CFN99491 1447-88-7 50mg QQ客服:215959384
    高车前素 CFN99491 1447-88-7 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Brasilia (Brazil)
  • Medizinische Universit?t Wien (Austria)
  • University of Auckland (New Zealand)
  • Macau University of Science and Technology (China)
  • Universitas Airlangga (Indonesia)
  • University of Toulouse (France)
  • Complutense University of Madrid (Spain)
  • Instituto Politécnico de Bragan?a (Portugal)
  • University of Hull (United Kingdom)
  • Universiti Sains Malaysia (Malaysia)
  • University of Minnesota (USA)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Florida A&M University (USA)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Science and Biotechnology2015, 2205-2212
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Pharmacol Rep.2017, 69(6):1224-1231
  • Front Immunol.2017, 8:1542
  • Industrial Crops and Products2017, 95:286-295
  • Nutrients.2018, 10(10)
  • Analytical Methods2018, 10(27)
  • Nat Prod Communications2018, 10.1177
  • Phytochemistry2018, 15:83-92
  • Molecules.2018, 23(10):E2638
  • Sci Rep. 2018, 462(8)
  • Sci Rep.2018, 8:15059
  • Cell Death Dis.2019, 10(12):882
  • Nutr Res Pract2019, 13:e45
  • J of Physics Conference Series2019, 1349(1)
  • Molecules.2019, 24(11):E2102
  • Phytother Res.2019, 33(5):1490-1500
  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
  • Int J Mol Med.2019, 43(6):2516-2522
  • Phytomedicine.2019, 67:153159
  • Biomed Chromatogr.2019, 8:e4774
  • J Sep Sci.2020, 201901140
  • ...
  • 生物活性
    Description: Hispidulin has anti-oxidative, anti-inflammatory, anti-cancer, antiepileptic, neuroprotective, anti-osteoporotic and bone resorption attenuating effects, it targets the VEGF receptor 2-mediated PI3K/Akt/mTOR signaling pathway in endothelial cells, leading to the suppression of pancreatic tumor growth and angiogenesis. Hispidulin can ameliorate high glucose-mediated endothelial dysfunction via inhibiting PKCβII-associated NLRP3 inflammasome activation and NF-κB signaling, it has potential application in the prevention and treatment of diabetic vascular complications. Hispidulin can inhibit platelet aggregation by elevating cAMP levels by a mechanism different from that of theophylline or PGE1.
    Targets: HIF | AMPK | P-gp | IL Receptor | NF-kB | TNF-α | MAPK | IkB | VEGFR | PI3K | Akt | mTOR | PGE | cAMP | IKK
    In vitro:
    J. Funct. Foods, 2016, 27:392-405.
    Ameliorative effects of hispidulin on high glucose-mediated endothelial dysfunction via inhibition of PKCβII-associated NLRP3 inflammasome activation and NF-κB signaling in endothelial cells[Reference: WebLink]
    Endothelial dysfunction is closely relevant to atherosclerosis complications in diabetic patients. Hispidulin, a flavone derived from the herb Salvia plebeia R. Br., has numerous biological properties including anti-inflammatory and antioxidative effects, but the underlying mechanism of its anti-inflammatory action remains unclear. This study was designed to investigate the effects of Hispidulin on endothelial homeostasis and its mechanism.
    METHODS AND RESULTS:
    Hispidulin effectively inhibited high glucose-induced oxidative stress by attenuating PKCβII phosphorylation and downstream reactive oxygen species (ROS) production, furthermore reversing the loss of mitochondria membrane potential. Moreover, Hispidulin significantly suppressed the expression of NLRP3 inflammasome and IKKβ/NF-κB, and restored high glucose-impaired vasodilation in rat aorta.
    CONCLUSIONS:
    This study demonstrated that Hispidulin ameliorated high glucose-mediated endothelial dysfunction via inhibiting PKCβII-associated NLRP3 inflammasome activation and NF-κB signaling. Besides, these findings indicate the beneficial effects of Hispidulin on the improvement of endothelial dysfunction and explain its potential application in the prevention and treatment of diabetic vascular complications.
    Eur J Pharmacol. 1988 Feb 16;147(1):1-6.
    Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels.[Pubmed: 2836213]
    Hispidulin, a natural flavone, and theophylline inhibited platelet aggregation triggered by adenosine-5'-monophosphate, arachidonic acid, paf-acether and collagen.
    METHODS AND RESULTS:
    Hispidulin was 100-fold more potent than theophylline. A threshold concentration of PGE1 did not modify the anti-aggregatory effect of hispidulin but potentiated the effect of theophylline. A threshold concentration of hispidulin had no effect on the inhibitory action of theophylline. Hispidulin (100 microM) and theophylline (10 mM) increased the control cAMP level in platelets 4-fold. A threshold concentration of PGE1 had a small effect on hispidulin-induced cAMP levels but increased the theophylline-induced cAMP levels 3-fold. Theophylline (10 mM)-induced cAMP levels were not modified by hispidulin. We demonstrate a correlation between the inhibition of platelet aggregation and the increase in cAMP levels induced by hispidulin.
    CONCLUSIONS:
    These data suggest that hispidulin could inhibit platelet aggregation by elevating cAMP levels by a mechanism different from that of theophylline or PGE1.
    In vivo:
    Eur J Pharmacol. 2015 May 15;755:6-15.
    Protective effect of hispidulin on kainic acid-induced seizures and neurotoxicity in rats.[Pubmed: 25746462]
    Hispidulin is a flavonoid compound which is an active ingredient in a number of traditional Chinese medicinal herbs, and it has been reported to inhibit glutamate release. The purpose of this study was to investigate whether Hispidulin protects against seizures induced by kainic acid, a glutamate analog with excitotoxic properties.
    METHODS AND RESULTS:
    The results indicated that intraperitoneally administering Hispidulin (10 or 50mg/kg) to rats 30min before intraperitoneally injecting kainic acid (15mg/kg) increased seizure latency and decreased seizure score. In addition, Hispidulin substantially attenuated kainic acid-induced hippocampal neuronal cell death, and this protective effect was accompanied by the suppression of microglial activation and the production of proinflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α in the hippocampus. Moreover, Hispidulin reduced kainic acid-induced c-Fos expression and the activation of mitogen-activated protein kinases in the hippocampus.
    CONCLUSIONS:
    These data suggest that Hispidulin has considerable antiepileptic, neuroprotective, and antiinflammatory effects on kainic acid-induced seizures in rats.
    Cell Biochem Biophys. 2014 Jun;69(2):311-7.
    Hispidulin exerts anti-osteoporotic activity in ovariectomized mice via activating AMPK signaling pathway.[Pubmed: 24338527]
    To investigate the effect of Hispidulin on ovariectomy (OVX)-induced bone loss in mice.
    METHODS AND RESULTS:
    Female mice subjected to OVX were treated with Hispidulin for 8 weeks. The total body bone mineral density was measured at the beginning and after the OVX at a time interval of 4 weeks. Micro-computed tomography of the tibia, bone histomorphometric analysis of the femur, and biomechanical analysis of tibia, vertebra, and femoral head were performed to fully evaluate the anti-osteoporotic effect of Hispidulin. Western blot analysis was performed to determine the level of activated AMPK. Hispidulin treatment effectively prevented OVX-induced body weight loss and attenuated OVX-induced bone loss. Hispidulin treatment also decreased trabecular spacing in OVX mice. The suppressing effect of Hispidulin on osteoclast surface and number was also found via histomorphometric analysis. Western blot analysis revealed that Hispidulin significantly elevated the activated AMPK levels.
    CONCLUSIONS:
    Our findings suggest that Hispidulin exerts anti-osteoporotic and bone resorption attenuating effects via activating the AMPK signaling pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.33 mL 16.65 mL 33.3 mL 66.6001 mL 83.2501 mL
    5 mM 0.666 mL 3.33 mL 6.66 mL 13.32 mL 16.65 mL
    10 mM 0.333 mL 1.665 mL 3.33 mL 6.66 mL 8.325 mL
    50 mM 0.0666 mL 0.333 mL 0.666 mL 1.332 mL 1.665 mL
    100 mM 0.0333 mL 0.1665 mL 0.333 mL 0.666 mL 0.8325 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    石吊兰甲素; Lysionotin CFN99787 152743-19-6 C18H16O7 = 344.32 20mg QQ客服:1148253675
    栀子黄素B; Gardenin B CFN93144 2798-20-1 C19H18O7 = 358.4 10mg QQ客服:215959384
    桔皮素; Tangeretin CFN90240 481-53-8 C20H20O7 = 372.37 20mg QQ客服:215959384
    5,4'-二羟基黄酮; 4',5-Dihydroxyflavone CFN97137 6665-67-4 C15H10O4 = 254.2 5mg QQ客服:1413575084
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮; Apigenin CFN98843 520-36-5 C15H10O5 = 270.2 20mg QQ客服:3257982914
    芫花素; Genkwanin CFN98670 437-64-9 C16H12O5 = 284.3 20mg QQ客服:1413575084
    黄花夹竹桃黄酮; Thevetiaflavone CFN96124 29376-68-9 C16H12O5 = 284.3 5mg QQ客服:2159513211
    野黄芩素; Scutellarein CFN98557 529-53-3 C15H10O6 = 286.24 20mg QQ客服:2159513211
    高车前素; Hispidulin CFN99491 1447-88-7 C16H12O6 = 300.3 20mg QQ客服:2932563308
    蓟黄素; Cirsimaritin CFN97126 6601-62-3 C17H14O6 = 314.3 5mg QQ客服:1413575084

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