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  • 黄花夹竹桃黄酮

    Thevetiaflavone

    黄花夹竹桃黄酮
    产品编号 CFN96124
    CAS编号 29376-68-9
    分子式 = 分子量 C16H12O5 = 284.3
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Wikstroemia indica
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄花夹竹桃黄酮 CFN96124 29376-68-9 1mg QQ客服:1148253675
    黄花夹竹桃黄酮 CFN96124 29376-68-9 5mg QQ客服:1148253675
    黄花夹竹桃黄酮 CFN96124 29376-68-9 10mg QQ客服:1148253675
    黄花夹竹桃黄酮 CFN96124 29376-68-9 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Utah State University (USA)
  • University of Hertfordshire (United Kingdom)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • University of Pretoria (South Africa)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Texas A&M University (USA)
  • University of Zurich (Switzerland)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • University of Padjajaran (Indonesia)
  • Auburn University (USA)
  • University of Vienna (Austria)
  • University of Fribourg (Switzerland)
  • University of Maryland School of Medicine (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • PLoS One.2015, 10(5):e0127060
  • Proc Natl Acad Sci USA.2016, 113(30):E4407-1
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • The Korea Journal of Herbology2016, 29-35
  • J Pharm Anal.2016, 6(6):363-373
  • J Nat Med.2017, 71(2):380-388
  • Oncotarget.2017, 8(53):90925-90947
  • Arch Toxicol.2017, 91(10):3225-3245
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Mol Pharm.2018, 15(8):3285-3296
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Sci Rep.2018, 8(1):12970
  • Saf Health Work.2019, 10(2):196-204
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • Molecules.2019, 24(10):E1930
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Phytomedicine.2019, 56:48-56
  • Metabolites.2019, 9(11):E271
  • J Cell Physiol.2020, 10.1002
  • Saudi Pharm J2020, 10.1016
  • Food and Chemical Toxicology2020, 111221
  • Food Res Int.2020, 128:108778
  • ...
  • 生物活性
    Description: Thevetiaflavone ameliorates PC12 cells injury induced by OGD/R via improving ROS‑mediated mitochondrial dysfunction, it can upregulate the expression of Bcl‑2 and downregulate that of Bax and caspase‑3.
    Targets: Bcl‑2/Bax | Caspase | ROS
    In vitro:
    BMC Complement Altern Med. 2017 May 2;17(1):241.
    Anticancer potential of Thevetia peruviana fruit methanolic extract.[Pubmed: 28464893 ]
    Thevetia peruviana (Pers.) K. Schum or Cascabela peruviana (L.) Lippold (commonly known as ayoyote, codo de fraile, lucky nut, or yellow oleander), native to Mexico and Central America, is a medicinal plant used traditionally to cure diseases like ulcers, scabies, hemorrhoids and dissolve tumors. The purpose of this study was to evaluate the cytotoxic, antiproliferative and apoptotic activity of methanolic extract of T. peruviana fruits on human cancer cell lines.
    METHODS AND RESULTS:
    The cytotoxic activity of T. peruviana methanolic extract was carried out on human breast, colorectal, prostate and lung cancer cell lines and non-tumorigenic control cells (fibroblast and Vero), using the MTT assay. For proliferation and motility, clonogenic and wound-healing assays were performed. Morphological alterations were monitored by trypan blue exclusion, as well as DNA fragmentation and AO/EB double staining was performed to evaluate apoptosis. The extract was separated using flash chromatography, and the resulting fractions were evaluated on colorectal cancer cells for their cytotoxic activity. The active fractions were further analyzed through mass spectrometry. The T. peruviana methanolic extract exhibited cytotoxic activity on four human cancer cell lines: prostate, breast, colorectal and lung, with values of IC50 1.91 ± 0.76, 5.78 ± 2.12, 6.30 ± 4.45 and 12.04 ± 3.43 μg/mL, respectively. The extract caused a significant reduction of cell motility and colony formation on all evaluated cancer cell lines. In addition, morphological examination displayed cell size reduction, membrane blebbing and detachment of cells, compared to non-treated cancer cell lines. The T. peruviana extract induced apoptotic cell death, which was confirmed by DNA fragmentation and AO/EB double staining. Fractions 4 and 5 showed the most effective cytotoxic activity and their MS analysis revealed the presence of the secondary metabolites: thevetiaflavone and cardiac glycosides.
    CONCLUSIONS:
    T. peruviana extract has potential as natural anti-cancer product with critical effects in the proliferation, motility, and adhesion of human breast and colorectal cancer cells, and apoptosis induction in human prostate and lung cancer cell lines, with minimal effects on non-tumorigenic cell lines.
    Mol Med Rep. 2017 Dec;16(6):9197-9202.
    Thevetiaflavone from Wikstroemia indica ameliorates PC12 cells injury induced by OGD/R via improving ROS‑mediated mitochondrial dysfunction.[Pubmed: 28990067 ]
    Cerebral ischemia and following reperfusion affects many people worldwide. To discover efficient therapeutic approaches, numerous natural products have been investigated.
    METHODS AND RESULTS:
    The current study investigated the protective effects of thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, and the associated mechanisms using PC12 cells induced by oxygen and glucose deprivation. As a result, thevetiaflavone improves cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that thevetiaflavone decreases overproduction of ROS and ameliorates ROS‑mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening.
    CONCLUSIONS:
    Thevetiaflavone reduces the intracellular Ca2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl‑2 and downregulating that of Bax and caspase‑3 in addition to increasing the activity of caspase‑3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5174 mL 17.5871 mL 35.1741 mL 70.3482 mL 87.9353 mL
    5 mM 0.7035 mL 3.5174 mL 7.0348 mL 14.0696 mL 17.5871 mL
    10 mM 0.3517 mL 1.7587 mL 3.5174 mL 7.0348 mL 8.7935 mL
    50 mM 0.0703 mL 0.3517 mL 0.7035 mL 1.407 mL 1.7587 mL
    100 mM 0.0352 mL 0.1759 mL 0.3517 mL 0.7035 mL 0.8794 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5,4'-二羟基黄酮; 4',5-Dihydroxyflavone CFN97137 6665-67-4 C15H10O4 = 254.2 5mg QQ客服:1148253675
    芹菜素; 芹黄素; 5,7,4'-三羟基黄酮; Apigenin CFN98843 520-36-5 C15H10O5 = 270.2 20mg QQ客服:2932563308
    芫花素; Genkwanin CFN98670 437-64-9 C16H12O5 = 284.3 20mg QQ客服:1413575084
    黄花夹竹桃黄酮; Thevetiaflavone CFN96124 29376-68-9 C16H12O5 = 284.3 5mg QQ客服:1413575084
    野黄芩素; Scutellarein CFN98557 529-53-3 C15H10O6 = 286.24 20mg QQ客服:1148253675
    高车前素; Hispidulin CFN99491 1447-88-7 C16H12O6 = 300.3 20mg QQ客服:215959384
    蓟黄素; Cirsimaritin CFN97126 6601-62-3 C17H14O6 = 314.3 5mg QQ客服:2932563308
    4'-羟基汉黄芩素; 4'-Hydroxywogonin CFN98960 57096-02-3 C16H12O6 = 300.3 10mg QQ客服:3257982914
    5,8-二羟基-2-(4-羟基苯基)-6,7-二甲氧基-4H- 1-苯并吡喃-4-酮; Isothymusin CFN97562 98755-25-0 C17H14O7 = 330.3 5mg QQ客服:3257982914
    金合欢素; 刺槐素; Acacetin CFN98744 480-44-4 C16H12O5 = 284.3 20mg QQ客服:2932563308

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