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  • 紫草素

    Shikonin

    紫草素
    产品编号 CFN99907
    CAS编号 517-88-4
    分子式 = 分子量 C16H16O5 = 288.31
    产品纯度 >=98%
    物理属性 Purple powder
    化合物类型 Quinones
    植物来源 The roots of Lithosperraum erythrorhizon Sieb. et Zucc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    紫草素 CFN99907 517-88-4 10mg QQ客服:2159513211
    紫草素 CFN99907 517-88-4 20mg QQ客服:2159513211
    紫草素 CFN99907 517-88-4 50mg QQ客服:2159513211
    紫草素 CFN99907 517-88-4 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • University of Toronto (Canada)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Rio de Janeiro State University (Brazil)
  • University of Fribourg (Switzerland)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Medizinische Universit?t Wien (Austria)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Massachusetts General Hospital (USA)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • University of Wisconsin-Madison (USA)
  • Universidade da Beira Interior (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Processes2021, 9(11),2065.
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • Food Chem.2019, 276:768-775
  • Molecules2022, 27(9):2992.
  • Front Pharmacol.2019, 10:1355
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • Univerzita Karlova2022, 173245.
  • Neurotox Res.2020, 38(1):163-174.
  • Plant Cell Physiol.2018, 59(1):128-141
  • J Biol Chem.2014, 289(3):1723-31
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Chem Biol Interact.2018, 290:44-51
  • Biomed Pharmacother.2022, 156:113929.
  • J. Traditional Thai Medical Res. 2022,8(1):1-14.
  • Daru.2022, 30(2):273-288.
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Am J Chin Med.2016, 44(6):1255-1271
  • Pharm Biol.2022, 60(1):2040-2048.
  • Internoational J of Toxicology2020, 10.1177.
  • Phytomedicine.2019, 65:153089
  • Viruses2023, 15(6), 1377
  • Preprints2021, doi:10.20944
  • ...
  • 生物活性
    Description: Shikonin is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, and some food products; shikonin also enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. It can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway.
    Targets: PI3K | Akt | TLR | NF-kB | MMP(e.g.TIMP) | ROS | Bcl-2/Bax | Caspase | PARP | p53 | Antifection
    In vitro:
    J Pharm Pharmacol. 2015 Apr 16.
    Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC-803 via the Toll-like receptor 2/nuclear factor-kappa B pathway.[Pubmed: 25880237]
    Shikonin is an active naphthoquinone pigment isolated from the root of Lithospermum erythrorhizon. This study was designed to explore the inhibition of Shikonin on cell viability, adhesion, migration and invasion ability of gastric cancer (GC) and its possible mechanism.
    METHODS AND RESULTS:
    3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed for cell viability and adhesion ability of MGC-803 cells. Cell scratch repair experiments were conducted for the determination of migration ability while transwell assay for cell invasion ability. Western blot analysis and real-time polymerase chain reaction assay were used for the detection of protein and mRNA expressions. Fifty per cent inhibitory concentration of Shikonin on MGC-803 cells was 1.854 μm. Shikonin (1 μm) inhibited significantly the adhesion, invasion and migratory ability of MGC-803 cells. Interestingly, Shikonin in the presence or absence of anti-Toll-like receptor 2 (TLR2) antibody (2 μg) and nuclear factor-kappa B (NF-κB) inhibitor MG-132 (10 μm) could decrease these ability of MGC-803 cells markedly, as well as the expression levels of matrix metalloproteinases (MMP)-2, MMP-7, TLR2 and p65 NF-κB. In addition, the co-incubation of Shikonin and anti-TLR2/MG-132 has a significant stronger activity than anti-TLR2 or MG-132 alone.
    CONCLUSIONS:
    The results indicated that Shikonin could suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway. Our findings provide novel information for the treatment of Shikonin on GC.
    Pharm.Chem. J., 2001, 35(8):435-6.
    Antimicrobial Activity of Shikonin Preparations.[Reference: WebLink]
    Shikonin is a natural red naphthoquinone pigment synthesized in the roots of plants belonging to the Boraginaceae family.
    METHODS AND RESULTS:
    At present, a purified Shikonin preparation is widely used in Japan for the production of medicinals, cosmetics, and some food products [1]. In Russia, Shikonin enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. Shikonin possesses a broad spectrum of antimicrobial activity.
    CONCLUSIONS:
    In this context, it was of interest to study the antimicrobial properties of commercial Shikonin and the related aqueous ethanol and oil extracts from the cell culture of Arnebia euchroma.
    In vivo:
    Cell Physiol Biochem . 2018;45(6):2461-2470.
    Alkannin Inhibited Hepatic Inflammation in Diabetic Db/Db Mice[Pubmed: 29554661]
    Abstract Background/aims: The current study was designed to investigate the protective role of alkannin (ALK) on liver injury in diabetic C57BL/KsJ-db/db mice and explore its potential mechanisms. Methods: An oral glucose tolerance test (OGTT) was performed. The levels of insulin, alanine aminotransferase (ALT), aspartate aminotransaminase (AST), total cholesterol (TC) and triglyceride (TG) were determined by commercial kits. The pro-inflammatory cytokines interleukin (IL)-1β, IL-6 and tumour necrosis factor (TNF)-α were determined by ELISA. The levels of the ROCK/NF-κB pathway were determined by Western blotting. Results: The contents of pro-inflammatory cytokines interleukin (IL)-1β, IL-6 and tumour necrosis factor (TNF)-α were inhibited by ALK, metformin or fasudil in diabetic db/db mice. Further, Western blotting analysis showed that the expression of Rho, ROCK1, ROCK2, p-NF-κBp65, and p-IκBα was significantly reversed by ALK treatment. In human hepatic HepG2 cells, the hepatoprotective effects of ALK were further characterized. With response to palmitic acid-challenge, increased amounts of insulin, ALT, AST, TG, and TC were observed, whereas ALK pretreatment significantly inhibited their leakage in HepG2 cells without appreciable cytotoxic effects. The inflammation condition was recovered with ALK treatment as shown by changes of IL-1β, IL-6 and TNF-α. Further, Western blotting analysis also suggested that ALK improves hepatic inflammation in a Rho-kinase pathway. Conclusion: The present study successfully investigated the role of Rho-kinase signalling in diabetic liver injury. ALK exhibited hepatoprotective effects in diabetic db/db mice, and it might act through improving hepatic inflammation through the Rho-kinase pathway. Keywords: Alkannin; Inflammation; Liver injury; Rho-kinase pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4685 mL 17.3424 mL 34.6849 mL 69.3698 mL 86.7122 mL
    5 mM 0.6937 mL 3.4685 mL 6.937 mL 13.874 mL 17.3424 mL
    10 mM 0.3468 mL 1.7342 mL 3.4685 mL 6.937 mL 8.6712 mL
    50 mM 0.0694 mL 0.3468 mL 0.6937 mL 1.3874 mL 1.7342 mL
    100 mM 0.0347 mL 0.1734 mL 0.3468 mL 0.6937 mL 0.8671 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    β,β-二甲基丙烯酰紫草素; Dimethylacrylshikonin CFN90164 24502-79-2 C21H22O6 = 370.39 20mg QQ客服:1457312923
    β,β-二甲基丙烯酰阿卡宁; Beta,beta-Dimethylacrylalkannin CFN90626 34539-65-6 C21H22O6 = 370.4 20mg QQ客服:1457312923
    异戊酰紫草素; Isovalerylshikonin CFN95222 52387-14-1 C21H24O6 = 372.4 10mg QQ客服:215959384
    Beta-羟基异戊酰紫草素; Beta-Hydroxyisovalerylshikonin CFN93028 7415-78-3 C21H24O7 = 388.42 5mg QQ客服:3257982914
    乙酰氧基异戊酰阿卡宁; Acetoxyisovalerylalkannin CFN92025 69091-17-4 C23H26O8 = 430.5 20mg QQ客服:3257982914
    黄钟花醌; Lapachol CFN97403 84-79-7 C15H14O3 = 242.3 20mg QQ客服:1413575084
    去氧紫草素; Deoxyshikonin CFN92024 43043-74-9 C16H16O4 = 272.3 5mg QQ客服:3257982914
    紫草素; Shikonine CFN92622 517-89-5 C16H16O5 = 288.3 20mg QQ客服:1457312923
    紫草素; Shikonin CFN99907 517-88-4 C16H16O5 = 288.31 20mg QQ客服:1413575084
    乙酰紫草素; Acetylshikonin CFN90308 54984-93-9 C18H18O6 = 330.33 20mg QQ客服:2056216494

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