• 中药标准品生产商,产品定制服务
  • 紫草素

    Shikonin

    紫草素
    产品编号 CFN99907
    CAS编号 517-88-4
    分子式 = 分子量 C16H16O5 = 288.31
    产品纯度 >=98%
    物理属性 Purple powder
    化合物类型 Quinones
    植物来源 The roots of Lithosperraum erythrorhizon Sieb. et Zucc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    紫草素 CFN99907 517-88-4 10mg QQ客服:3257982914
    紫草素 CFN99907 517-88-4 20mg QQ客服:3257982914
    紫草素 CFN99907 517-88-4 50mg QQ客服:3257982914
    紫草素 CFN99907 517-88-4 100mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of Leipzig (Germany)
  • Universitas Airlangga (Indonesia)
  • Rio de Janeiro State University (Brazil)
  • Shanghai University of TCM (China)
  • University of Canterbury (New Zealand)
  • University of Amsterdam (Netherlands)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Colorado State University (USA)
  • Technical University of Denmark (Denmark)
  • University of Pretoria (South Africa)
  • University of Minnesota (USA)
  • S.N.D.T. Women's University (India)
  • University of Malaya (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Commun.2014, 9(5):679-82
  • Mediators Inflamm. 2016, 2016:6189590
  • Molecules.2016, 21(10)
  • Am J Chin Med.2016, 44(6):1255-1271
  • Int J Oncol.2016, 49(4):1497-504
  • J Ethnopharmacol.2017, 209:305-316
  • Korean j.of Pharm.2017, 70-76
  • J Cell Biochem.2018, 119(2):2231-2239
  • South African J of Plant&Soil2018, 29-32
  • Biochem Biophys Res Commun.2018, 505(1):261-266
  • Korean J. Crop Sci.2018, 63(2):131-139
  • Front Plant Sci.2018, 9:1424
  • J Cancer.2019, 10(23):5843-5851
  • Chemistry of Plant Materials.2019, 215-222
  • Molecules.2019, 24(22):E4022
  • The Korea Journal of Herbology2019, 34(2):25-32
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Appl Biol Chem2019, 62:46
  • Food Sci Nutr.2019, 8(1):246-256
  • Sci Rep.2019, 9(1):6429
  • Br J Pharmacol.2020, 10.1111
  • Oxid Med Cell Longev2020, 12
  • Biochem Biophys Res Commun.2020, 522(4):1052-1058
  • ...
  • 生物活性
    Description: Shikonin is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, and some food products; shikonin also enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. It can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway.
    Targets: PI3K | Akt | TLR | NF-kB | MMP(e.g.TIMP) | ROS | Bcl-2/Bax | Caspase | PARP | p53 | Antifection
    In vitro:
    J Pharm Pharmacol. 2015 Apr 16.
    Shikonin inhibits the cell viability, adhesion, invasion and migration of the human gastric cancer cell line MGC-803 via the Toll-like receptor 2/nuclear factor-kappa B pathway.[Pubmed: 25880237]
    Shikonin is an active naphthoquinone pigment isolated from the root of Lithospermum erythrorhizon. This study was designed to explore the inhibition of Shikonin on cell viability, adhesion, migration and invasion ability of gastric cancer (GC) and its possible mechanism.
    METHODS AND RESULTS:
    3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed for cell viability and adhesion ability of MGC-803 cells. Cell scratch repair experiments were conducted for the determination of migration ability while transwell assay for cell invasion ability. Western blot analysis and real-time polymerase chain reaction assay were used for the detection of protein and mRNA expressions. Fifty per cent inhibitory concentration of Shikonin on MGC-803 cells was 1.854 μm. Shikonin (1 μm) inhibited significantly the adhesion, invasion and migratory ability of MGC-803 cells. Interestingly, Shikonin in the presence or absence of anti-Toll-like receptor 2 (TLR2) antibody (2 μg) and nuclear factor-kappa B (NF-κB) inhibitor MG-132 (10 μm) could decrease these ability of MGC-803 cells markedly, as well as the expression levels of matrix metalloproteinases (MMP)-2, MMP-7, TLR2 and p65 NF-κB. In addition, the co-incubation of Shikonin and anti-TLR2/MG-132 has a significant stronger activity than anti-TLR2 or MG-132 alone.
    CONCLUSIONS:
    The results indicated that Shikonin could suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway. Our findings provide novel information for the treatment of Shikonin on GC.
    Pharm.Chem. J., 2001, 35(8):435-6.
    Antimicrobial Activity of Shikonin Preparations.[Reference: WebLink]
    Shikonin is a natural red naphthoquinone pigment synthesized in the roots of plants belonging to the Boraginaceae family.
    METHODS AND RESULTS:
    At present, a purified Shikonin preparation is widely used in Japan for the production of medicinals, cosmetics, and some food products [1]. In Russia, Shikonin enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. Shikonin possesses a broad spectrum of antimicrobial activity.
    CONCLUSIONS:
    In this context, it was of interest to study the antimicrobial properties of commercial Shikonin and the related aqueous ethanol and oil extracts from the cell culture of Arnebia euchroma.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4685 mL 17.3424 mL 34.6849 mL 69.3698 mL 86.7122 mL
    5 mM 0.6937 mL 3.4685 mL 6.937 mL 13.874 mL 17.3424 mL
    10 mM 0.3468 mL 1.7342 mL 3.4685 mL 6.937 mL 8.6712 mL
    50 mM 0.0694 mL 0.3468 mL 0.6937 mL 1.3874 mL 1.7342 mL
    100 mM 0.0347 mL 0.1734 mL 0.3468 mL 0.6937 mL 0.8671 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Beta-羟基异戊酰紫草素; Beta-Hydroxyisovalerylshikonin CFN93028 7415-78-3 C21H24O7 = 388.42 5mg QQ客服:1148253675
    乙酰氧基异戊酰阿卡宁; Acetoxyisovalerylalkannin CFN92025 69091-17-4 C23H26O8 = 430.5 20mg QQ客服:3257982914
    黄钟花醌; Lapachol CFN97403 84-79-7 C15H14O3 = 242.3 20mg QQ客服:2932563308
    去氧紫草素; Deoxyshikonin CFN92024 43043-74-9 C16H16O4 = 272.3 20mg QQ客服:2932563308
    紫草素; Shikonine CFN92622 517-89-5 C16H16O5 = 288.3 20mg QQ客服:3257982914
    紫草素; Shikonin CFN99907 517-88-4 C16H16O5 = 288.31 20mg QQ客服:1413575084
    乙酰紫草素; Acetylshikonin CFN90308 54984-93-9 C18H18O6 = 330.33 20mg QQ客服:215959384
    异丁酰紫草; Isobutylshikonin CFN92023 52438-12-7 C20H22O6 = 358.4 10mg QQ客服:1148253675
    β,β-二甲基丙烯酰紫草素; Dimethylacrylshikonin CFN90164 24502-79-2 C21H22O6 = 370.39 20mg QQ客服:1148253675
    β,β-二甲基丙烯酰阿卡宁; Beta,beta-Dimethylacrylalkannin CFN90626 34539-65-6 C21H22O6 = 370.4 20mg QQ客服:1148253675

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产