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  • β,β-二甲基丙烯酰阿卡宁

    Beta,beta-Dimethylacrylalkannin

    β,β-二甲基丙烯酰阿卡宁
    产品编号 CFN90626
    CAS编号 34539-65-6
    分子式 = 分子量 C21H22O6 = 370.4
    产品纯度 >=98%
    物理属性 Reddish brown powder
    化合物类型 Quinones
    植物来源 The roots of Lithospermum erythrorhizon
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    β,β-二甲基丙烯酰阿卡宁 CFN90626 34539-65-6 10mg QQ客服:1413575084
    β,β-二甲基丙烯酰阿卡宁 CFN90626 34539-65-6 20mg QQ客服:1413575084
    β,β-二甲基丙烯酰阿卡宁 CFN90626 34539-65-6 50mg QQ客服:1413575084
    β,β-二甲基丙烯酰阿卡宁 CFN90626 34539-65-6 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Regional Crop Research Institute (Korea)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Instituto Politécnico de Bragan?a (Portugal)
  • University of Illinois (USA)
  • Universidade do Porto (Portugal)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Griffith University (Australia)
  • University Medical Center Mainz (Germany)
  • Universidad Miguel Hernández (Spain)
  • Kyushu University (Japan)
  • Chiang Mai University (Thailand)
  • Universidad Industrial de Santander (Colombia)
  • University of Vigo (Spain)
  • University of South Australia (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian Journal of Chemistry2014, 26(22):7811-7816
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Sci Rep.2016, 6:25094
  • Pharmacognosy Magazine2017, 13(52):868-874
  • BMC Complement Altern Med.2017, 17(1):384
  • Sci Rep.2017, 7(1):3249
  • Oncotarget.2017, 8(64):108006-108019
  • RSC Advances2017, 86
  • PLoS One.2018, 13(11):e0208055
  • Cell.2018, 172(1-2):249-261
  • Int J Mol Sci.2018, 19(2)
  • J Ethnopharmacol.2018, 210:88-94
  • Molecules.2018, 23(11):E2837
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • Biochemistry.2018, 57(40):5886-5896
  • Biomol Ther (Seoul).2019, 10.4062
  • Int J Biol Macromol.2019, 126:653-661
  • Int J Mol Sci.2019, 20(14):E3538
  • Life Sci.2019, 216:259-270
  • Pharmacol Rep.2019, 71(2):289-298
  • Front Plant Sci.2020, 10:1705
  • Biochem Biophys Res Commun.2020, 522(4):1052-1058
  • ...
  • 生物活性
    Description: Beta,beta-Dimethylacrylalkannin has radical scavenging activity, it exhibits inhibitory activities on PTP1B with IC50 values of 0.36±0.08 umol·L-1, it may be a new type of leading compounds for the treatment of diabetes. Beta,beta-Dimethylacrylalkannin has great potential as topo I inhibitors compared to other compounds and CPT-11, with 2-3uM inhibition value. Beta,beta-Dimethylacrylalkannin can be potential therapeutics against tumor cell growth because of its unique DNA damaging abilities additional to enzyme inhibition similar to those of doxorubicin.
    Targets: ROS | PTP1B | topo I
    In vitro:
    J Nat Prod. 2010 May 28;73(5):860-4.
    Cytotoxic naphthoquinones from Alkanna cappadocica ( perpendicular).[Pubmed: 20405844 ]
    In a continuing program to discover new anticancer agents from plants, especially naphthoquinones from the Alkanna genus, Alkanna cappadocica was investigated.
    METHODS AND RESULTS:
    Bioassay-guided fractionation of a dichloromethane/methanol (1:1) extract of the roots led to the isolation of four new and four known naphthoquinones. The known compounds are 11-deoxyalkannin (1), Beta,beta-Dimethylacrylalkannin (2), 11-O-acetylalkannin (3), and alkannin (4). The new compounds 5-O-methyl-11-deoxyalkannin (5), 8-O-methyl-11-deoxyalkannin (6), 5-O-methyl-11-O-acetylalkannin (7), and 5-O-methyl-Beta,beta-Dimethylacrylalkannin (8) were characterized by spectroscopic analyses (LC-ESIMS, 1D and 2D NMR). Cytotoxicity of the isolated compounds was evaluated versus 12 human cancer cell lines, HT-29, MDA-MB-231, PC-3, AU565, Hep G2, LNCaP, MCF7, HeLa, SK-BR-3, DU 145, Saos-2, and Hep 3B together with two normal cell lines, VERO and 3T3, by using the MTT assay. Compound 7 showed remarkable cytotoxicity with IC(50) values between 0.09 and 14.07 muM. It was more potent than the other compounds in six out of 12 cancer cell lines and the positive controls doxorubicin and etoposide.
    CONCLUSIONS:
    The mono-O-methylated alkannin derivatives and their cytotoxicities are reported for the first time.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6998 mL 13.4989 mL 26.9978 mL 53.9957 mL 67.4946 mL
    5 mM 0.54 mL 2.6998 mL 5.3996 mL 10.7991 mL 13.4989 mL
    10 mM 0.27 mL 1.3499 mL 2.6998 mL 5.3996 mL 6.7495 mL
    50 mM 0.054 mL 0.27 mL 0.54 mL 1.0799 mL 1.3499 mL
    100 mM 0.027 mL 0.135 mL 0.27 mL 0.54 mL 0.6749 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    紫草素; Shikonine CFN92622 517-89-5 C16H16O5 = 288.3 20mg QQ客服:1413575084
    紫草素; Shikonin CFN99907 517-88-4 C16H16O5 = 288.31 20mg QQ客服:2932563308
    乙酰紫草素; Acetylshikonin CFN90308 54984-93-9 C18H18O6 = 330.33 20mg QQ客服:215959384
    异丁酰紫草; Isobutylshikonin CFN92023 52438-12-7 C20H22O6 = 358.4 10mg QQ客服:3257982914
    β,β-二甲基丙烯酰紫草素; Dimethylacrylshikonin CFN90164 24502-79-2 C21H22O6 = 370.39 20mg QQ客服:1148253675
    β,β-二甲基丙烯酰阿卡宁; Beta,beta-Dimethylacrylalkannin CFN90626 34539-65-6 C21H22O6 = 370.4 20mg QQ客服:1413575084
    异戊酰紫草素; Isovalerylshikonin CFN95222 52387-14-1 C21H24O6 = 372.4 10mg QQ客服:2159513211
    Beta-羟基异戊酰紫草素; Beta-Hydroxyisovalerylshikonin CFN93028 7415-78-3 C21H24O7 = 388.42 5mg QQ客服:1413575084
    乙酰氧基异戊酰阿卡宁; Acetoxyisovalerylalkannin CFN92025 69091-17-4 C23H26O8 = 430.5 20mg QQ客服:1413575084
    黄钟花醌; Lapachol CFN97403 84-79-7 C15H14O3 = 242.3 20mg QQ客服:3257982914

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