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  • 异丁酰紫草

    Isobutylshikonin

    异丁酰紫草
    产品编号 CFN92023
    CAS编号 52438-12-7
    分子式 = 分子量 C20H22O6 = 358.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Quinones
    植物来源 The roots of Lithosperraum erythrorhizon Sieb. et Zucc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    异丁酰紫草 CFN92023 52438-12-7 1mg QQ客服:215959384
    异丁酰紫草 CFN92023 52438-12-7 5mg QQ客服:215959384
    异丁酰紫草 CFN92023 52438-12-7 10mg QQ客服:215959384
    异丁酰紫草 CFN92023 52438-12-7 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • J Ethnopharmacol.2016, 192:370-381
  • Chemistr of plant2016, 2016021195
  • BMC Complement Altern Med.2017, 17(1):393
  • Food Chem.2017, 221:1135-1144
  • FEMS Microbiol Lett.2017, 364(11)
  • Int. J. of Food Properties2017, S108-S118
  • PLoS One.2018, 13(4):e0195642
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Molecules.2018, 23(11):E2837
  • Molecules.2018, 23(7):E1817
  • Phytomedicine.2018, 38:12-23
  • Primary and Industrial.2018, 52(11)
  • Biochemistry.2018, 57(40):5886-5896
  • Sci Rep.2018, 8:15059
  • Cell Death Dis.2019, 10(12):882
  • Analytical methods2019, 11(6)
  • Postharvest Biol Tec2019, 149:18-26
  • Molecules.2019, 24(24),4583
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Kor. J. Herbol.2019, 34(2):59-66
  • Oncol Rep.2019, 41(4):2453-2463
  • Appl. Sci.2020, 10,1304
  • ...
  • 生物活性
    Description: Isobutylshikonin exhibits obvious antioxidant activities , it exerts very good radical scavenging activities toward ABTS+ but shows moderate inhibition of DPPH·.
    In vitro:
    J Agric Food Chem. 1999 Oct;47(10):4117-20.
    Physical stability of shikonin derivatives from the roots of Lithospermum erythrorhizon cultivated in Korea.[Pubmed: 10552776]

    METHODS AND RESULTS:
    Five red shikonin pigments, deoxyshikonin, shikonin, acetylshikonin, isobutylshikonin, and beta-hydroxyisovalerylshikonin, were isolated from the roots of Lithospermum erythrorhizon cultivated in Korea. The purified pigments were red, purple, and blue at acidic, neutral, and alkaline pH values, respectively. Physical stability of the purified pigments against heat and light in an aqueous solution was examined for possible value-added food colorants. The thermal degradation reactions were carried out at pH 3.0 (50 mM glycine buffer) in 50% EtOH/H(2)O. Deoxyshikonin (t(1/2) = 14.6 h, 60 degrees C) and isobutylshikinin (t(1/2) = 19.3 h, 60 degrees C) are relatively less stable than other shikonin derivatives (t(1/2) = 40-50 h, 60 degrees C). Activation energies of thermal degradation of the isolated pigments were calculated. The activation energy of deoxyshikonin was the highest (12.5 kcal mol(-)(1)) and that of beta-hydroxyisovalerylshikonin was the lowest (1.71 kcal mol(-)(1)) value.
    CONCLUSIONS:
    Light stabilities of the pigments were similar to each other in that the half-life values of photodegradation for 20000 lx light intensity were 4.2-5.1 h.
    Food Chemistry, 2008, 106(1):2-10.
    Antioxidants from a Chinese medicinal herb – Lithospermum erythrorhizon[Reference: WebLink]
    Seven compounds, deoxyshikonin (1), β,β-dimethylacrylshikonin (2), Isobutylshikonin (3), shikonin (4), 5,8-dihydroxy-2-(1-methoxy-4-methyl-3-pentenyl)-1,4-naphthalenedione (5), β-sitosterol (6) and a mixture of two caffeic acid esters [7 (7a,7b)] were isolated from Lithospermum erythrorhizon Sieb et. Zucc. and identified by spectroscopic methods. Among them, compound 5 was isolated from this plant species for the first time.
    METHODS AND RESULTS:
    The antioxidant activities of the seven compounds were compared and evaluated through Rancimat method, reducing power and radical scavenging activity. Results showed that, except compound 6, another 6 compounds all exhibited obvious antioxidant activities against four different methods. Compounds 4 and 7 exerted much more potent antioxidant effects on retarding the lard oxidation than that of BHT and both were found to exhibit strong reducing power. Their antioxidant activities, assessed by Rancimat method and reducing power, decreased in the following order, respectively: compound 7 > 4 > BHT > 2 > 3 > 5 > 1 > 6 and compound 7 > BHT > 4 > 2 approximately 3 approximately 5 > 1> 6. In addition, compounds 1-5 all exerted very good radical scavenging activities toward ABTS+ but showed moderate inhibition of DPPH·, while compound 7 presented as a powerful radical scavenger against both ABTS·+ and DPPH·.
    CONCLUSIONS:
    Thus, our results suggested that L. erythrorhizon could be a promising rich source of natural antioxidants.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7902 mL 13.9509 mL 27.9018 mL 55.8036 mL 69.7545 mL
    5 mM 0.558 mL 2.7902 mL 5.5804 mL 11.1607 mL 13.9509 mL
    10 mM 0.279 mL 1.3951 mL 2.7902 mL 5.5804 mL 6.9754 mL
    50 mM 0.0558 mL 0.279 mL 0.558 mL 1.1161 mL 1.3951 mL
    100 mM 0.0279 mL 0.1395 mL 0.279 mL 0.558 mL 0.6975 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异戊酰紫草素; Isovalerylshikonin CFN95222 52387-14-1 C21H24O6 = 372.4 10mg QQ客服:3257982914
    Beta-羟基异戊酰紫草素; Beta-Hydroxyisovalerylshikonin CFN93028 7415-78-3 C21H24O7 = 388.42 5mg QQ客服:3257982914
    乙酰氧基异戊酰阿卡宁; Acetoxyisovalerylalkannin CFN92025 69091-17-4 C23H26O8 = 430.5 20mg QQ客服:215959384
    黄钟花醌; Lapachol CFN97403 84-79-7 C15H14O3 = 242.3 20mg QQ客服:1413575084
    去氧紫草素; Deoxyshikonin CFN92024 43043-74-9 C16H16O4 = 272.3 20mg QQ客服:1413575084
    紫草素; Shikonine CFN92622 517-89-5 C16H16O5 = 288.3 20mg QQ客服:1413575084
    紫草素; Shikonin CFN99907 517-88-4 C16H16O5 = 288.31 20mg QQ客服:1148253675
    乙酰紫草素; Acetylshikonin CFN90308 54984-93-9 C18H18O6 = 330.33 20mg QQ客服:215959384
    异丁酰紫草; Isobutylshikonin CFN92023 52438-12-7 C20H22O6 = 358.4 10mg QQ客服:215959384
    β,β-二甲基丙烯酰紫草素; Dimethylacrylshikonin CFN90164 24502-79-2 C21H22O6 = 370.39 20mg QQ客服:2159513211

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