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    乙酰紫草素

    Acetylshikonin

    乙酰紫草素
    产品编号 CFN90308
    CAS编号 54984-93-9
    分子式 = 分子量 C18H18O6 = 330.33
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Quinones
    植物来源 The roots of Lithosperraum erythrorhizon Sieb. et Zucc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    乙酰紫草素 CFN90308 54984-93-9 10mg QQ客服:2159513211
    乙酰紫草素 CFN90308 54984-93-9 20mg QQ客服:2159513211
    乙酰紫草素 CFN90308 54984-93-9 50mg QQ客服:2159513211
    乙酰紫草素 CFN90308 54984-93-9 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Maryland School of Medicine (USA)
  • Universite Libre de Bruxelles (Belgium)
  • University of Oslo (Norway)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Universitas Airlangga (Indonesia)
  • Universiti Sains Malaysia (Malaysia)
  • Srinakharinwirot University (Thailand)
  • John Innes Centre (United Kingdom)
  • University of Medicine and Pharmacy (Romania)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Medical University of South Carolina (USA)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Chiang Mai University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antiviral Res.2013, 98(3):386-93
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Nat Prod Sci.2016, 22(2)
  • J Basic Clin Physiol Pharmacol.2016, 27(1):1-8
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • J Nat Med.2018, 72(3):734-744
  • Front Pharmacol.2018, 9:756
  • Mol Microbiol.2019, 112(1):317-332
  • Molecules.2019, 24(6):E1177
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • Phytomedicine.2019, 56:48-56
  • Pharmacological Reports2020, 1-9
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Appl. Sci.2020, 10(23), 8729
  • Pharmaceutics.2020, 12(9):845.
  • Nutr Res Pract.2020, 14(5):478-489.
  • Evid Based Complement Alternat Med.2020, 2020:8582318.
  • BMB Rep.2020, 53(4):218-222.
  • Nature Ecology & Evolution2020, doi: 10.1038
  • J Ethnopharmacol.2021, 267:113615.
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • J Nat Med.2021, doi: 10.1007.
  • ...
  • 生物活性
    Description: Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.
    Targets: JNK | AChR | Bcl-2/Bax | ERK | MAPK | HO-1 | COX | Calcium Channel | HBVX
    In vitro:
    Eur J Pharmacol. 2014 Jul 15;735:132-40.
    Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.[Pubmed: 24769509]

    METHODS AND RESULTS:
    When Acetylshikonin was added to Hep3B cells stably expressing HBX, it induced apoptosis in a dose-dependent manner. Acetylshikonin induced upregulation and export of Nur77 to the cytoplasm and activation of JNK. Likewise, suppression of Nur77 and JNK inactivation protected the cells from Acetylshikonin-induced apoptosis, indicating that Nur77 upregulation and JNK activation were required for Acetylshikonin-mediated apoptosis. Furthermore, Acetylshikonin increased the expression of Bip and ubiquitination levels of cellular proteins, features of endoplasmic reticulum (ER) stress, via the production of reactive oxygen species in a dose-dependent manner. Suppression of reactive oxygen species with N-acetylcysteine reduced levels of Bip protein and ubiquitination levels of cellular proteins during Acetylshikonintreatment, leading to protection of cells from apoptosis. Cycloheximide treatment reduced Acetylshikonin-induced ER stress, suggesting that protein synthesis is involved in Acetylshikonin-induced ER stress. Moreover, we showed using salubrinal, an ER stress inhibitor that reactive oxygen species production, Acetylshikonin activation, and Nur77 upregulation and its translocation to cytoplasm are necessary for ER-induced stress. Interestingly, we found that JNK inactivation suppresses Acetylshikonin-induced ER stress, whereas Nur77 siRNA treatment does not, indicating that JNK is required for Acetylshikonin-induced ER stress.
    CONCLUSIONS:
    Accordingly, we report that Acetylshikonin induces ER stress, which is prerequisite for apoptosis of HBX-expressing hepatocellular carcinoma cells.
    Evid Based Complement Alternat Med. 2013;2013:937370.
    Acetylshikonin, a Novel AChE Inhibitor, Inhibits Apoptosis via Upregulation of Heme Oxygenase-1 Expression in SH-SY5Y Cells.[Pubmed: 24302971]
    Acetylcholinesterase inhibitors are prominent alternative in current clinical treatment for AD patients. Therefore, there is a continued need to search for novel AChEIs with good clinical efficacy and less side effects.
    METHODS AND RESULTS:
    By using our in-house natural product database and AutoDock Vina as a tool in docking study, we have identified twelve phytochemicals (emodin, aloe-emodin, chrysophanol, and rhein in Rhei Radix Et Rhizoma; xanthotoxin, phellopterin, alloisoimperatorin, and imperatorin in Angelicae dahuricae Radix; shikonin, acetylshikonin, isovalerylshikonin, and β,β-dimethylacrylshikonin in Arnebiae Radix) as candidates of AChEIs that were not previously reported in the literature. In addition to AChEI activity, a series of cell-based experiments were conducted for the investigation of their neuroprotective activities. We found that acetylshikonin and its derivatives prevented apoptotic cell death induced by hydrogen peroxide in human and rat neuronal SH-SY5Y and PC12 cells at 10 μM.
    CONCLUSIONS:
    We showed that acetylshikonin exhibited the most potent antiapoptosis activity through the inhibition of the generation of reactive oxygen species as well as protection of the loss of mitochondria membrane potential. Furthermore, we identified for the first time that the upregulation of heme oxygenase 1 by acetylshikonin is a key step mediating its antiapoptotic activity from oxidative stress in SH-SY5Y cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0273 mL 15.1364 mL 30.2728 mL 60.5455 mL 75.6819 mL
    5 mM 0.6055 mL 3.0273 mL 6.0546 mL 12.1091 mL 15.1364 mL
    10 mM 0.3027 mL 1.5136 mL 3.0273 mL 6.0546 mL 7.5682 mL
    50 mM 0.0605 mL 0.3027 mL 0.6055 mL 1.2109 mL 1.5136 mL
    100 mM 0.0303 mL 0.1514 mL 0.3027 mL 0.6055 mL 0.7568 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    黄钟花醌; Lapachol CFN97403 84-79-7 C15H14O3 = 242.3 20mg QQ客服:1457312923
    去氧紫草素; Deoxyshikonin CFN92024 43043-74-9 C16H16O4 = 272.3 20mg QQ客服:3257982914
    紫草素; Shikonine CFN92622 517-89-5 C16H16O5 = 288.3 20mg QQ客服:2932563308
    紫草素; Shikonin CFN99907 517-88-4 C16H16O5 = 288.31 20mg QQ客服:2932563308
    乙酰紫草素; Acetylshikonin CFN90308 54984-93-9 C18H18O6 = 330.33 20mg QQ客服:2159513211
    异丁酰紫草; Isobutylshikonin CFN92023 52438-12-7 C20H22O6 = 358.4 10mg QQ客服:3257982914
    β,β-二甲基丙烯酰紫草素; Dimethylacrylshikonin CFN90164 24502-79-2 C21H22O6 = 370.39 20mg QQ客服:3257982914
    β,β-二甲基丙烯酰阿卡宁; Beta,beta-Dimethylacrylalkannin CFN90626 34539-65-6 C21H22O6 = 370.4 20mg QQ客服:1457312923
    异戊酰紫草素; Isovalerylshikonin CFN95222 52387-14-1 C21H24O6 = 372.4 10mg QQ客服:2056216494
    Beta-羟基异戊酰紫草素; Beta-Hydroxyisovalerylshikonin CFN93028 7415-78-3 C21H24O7 = 388.42 5mg QQ客服:3257982914

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