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  • β,β-二甲基丙烯酰紫草素

    Dimethylacrylshikonin

    β,β-二甲基丙烯酰紫草素
    产品编号 CFN90164
    CAS编号 24502-79-2
    分子式 = 分子量 C21H22O6 = 370.39
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Quinones
    植物来源 The roots of Lithosperraum erythrorhizon Sieb. et Zucc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    β,β-二甲基丙烯酰紫草素 CFN90164 24502-79-2 10mg QQ客服:2159513211
    β,β-二甲基丙烯酰紫草素 CFN90164 24502-79-2 20mg QQ客服:2159513211
    β,β-二甲基丙烯酰紫草素 CFN90164 24502-79-2 50mg QQ客服:2159513211
    β,β-二甲基丙烯酰紫草素 CFN90164 24502-79-2 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Helmholtz Zentrum München (Germany)
  • Stanford University (USA)
  • Rio de Janeiro State University (Brazil)
  • Tokyo Woman's Christian University (Japan)
  • University of Maryland School of Medicine (USA)
  • Worcester Polytechnic Institute (USA)
  • Pennsylvania State University (USA)
  • Kyung Hee University (Korea)
  • Sri Ramachandra University (India)
  • University of Maryland (USA)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:242
  • Chemistry of Plant Materials.2016, 33-46
  • J Ethnopharmacol.2017, 198:205-213
  • FEMS Microbiol Lett.2017, 364(11)
  • Oncotarget.2017, 8(53):90925-90947
  • Front Plant Sci.2017, 8:723
  • Int J Biol Macromol.2018, 112:1093-1103
  • Life Sci.2018, 209:498-506
  • Anat Rec2018, 24264
  • Food Chem.2018, 262:78-85
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Front Aging Neurosci.2019, 11:230
  • ACS Chem Biol.2019, 14(5):873-881
  • Int J Mol Sci.2019, 20(3):E651
  • Molecules.2019, 24(11):E2102
  • Food Chem.2019, 276:768-775
  • Food Chem.2019, 278:683-691
  • Phytomedicine.2019, 58:152893
  • Food Sci Nutr.2019, 8(1):246-256
  • Saudi Pharm J2020, 10.1016
  • Br J Pharmacol.2020, 10.1111
  • J Pharmaceut Biomed2020, 178:112894
  • J Ethnopharmacol.2020, 249:112381
  • ...
  • 生物活性
    Description: Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors, it inhibits the proliferation of MCF-7 cells in vitro by inducing apoptosis through the downregulation of Bcl-2, upregulation of Bax and partial inactivation of the NF-κB pathway. Dimethylacrylshikonin inhibits agonist-induced relaxation at lower concentrations and induces vasocontraction at higher concentrations.
    Targets: ROS | ERK | NF-kB | Bcl-2/Bax | Caspase | PARP | MEK | p38MAPK | Calcium Channel
    In vitro:
    Oncol Lett. 2014 Jun;7(6):1812-1818.
    β,β-Dimethylacrylshikonin sensitizes human colon cancer cells to ionizing radiation through the upregulation of reactive oxygen species.[Pubmed: 24932238]
    Shikonin, a naphthoquinone derivative, has been shown to possess antitumor activity.
    METHODS AND RESULTS:
    In the present study, the effects of shikonin and its analog, β,β-dimethylacrylshikonin, were investigated as radiosensitizers on the human colon cancer cell line, HCT-116. Shikonin and, to a greater extent, its analog-induced apoptosis of HCT-116 cells further synergistically potentiated the induction of apoptosis when combined with ionizing radiation (IR) treatment. Shikonins also stimulated an increase in reactive oxygen species (ROS) production and IR-induced DNA damage. Pre-treatment with the ROS scavenger, N-acetylcysteine, suppressed the enhancement of IR-induced DNA damage and apoptosis stimulated by shikonins, indicating that shikonins exert their radiosensitizing effects through ROS upregulation. The radiosensitizing effect of shikonins was also examined in vivo using the xenograft mouse model. Consistent with the in vitro results, injection of β,β-dimethylacrylshikonin combined with IR treatment significantly suppressed tumor growth of the HCT-116 xenograft.
    CONCLUSIONS:
    Taken together, the results show that β,β-dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors.
    Phytother Res. 2012 May;26(5):764-71.
    Inhibitory effects of β,β-dimethylacrylshikonin on hepatocellular carcinoma in vitro and in vivo.[Pubmed: 22109831]
    Dimethylacrylshikonin is one of the most abundant naphthoquinones in the root extracts of Lithospermum erythrorhizon Sieb. et Zucc. (Boraginaceae), which have been reported to have antitumor effects.
    METHODS AND RESULTS:
    This study evaluated the antiproliferative activity of Dimethylacrylshikonin on human hepatocellular carcinoma (HCC) cells both in vitro and in vivo. In vitro, the MTT assay showed that Dimethylacrylshikonin inhibited the proliferation of SMMC-7721 cells in both dose- and time-dependent manners with its 50% inhibitory concentration (IC(50) ) at 48 h being 15.01 ± 0.76 µg/mL. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) and Hoechst staining detected the characteristics of cell apoptosis in Dimethylacrylshikonin-treated cells and the apoptotic rates of treated groups were increased in a dose-dependent manner. Flow cytometric analysis revealed that Dimethylacrylshikonin could block the cell cycle arrest at G2 phase. Furthermore, Dimethylacrylshikonin down-regulated the mRNA and protein expression of Bcl-2 but up-regulated that of Bax. The cleaved caspase-3 protein was also detected in treated cells. The experiment in vivo showed that Dimethylacrylshikonin significantly suppressed the growth of H(22) transplantable hepatoma, and induced the activation of caspase-3 determined by immunohistochemistry.
    CONCLUSIONS:
    The results indicate that Dimethylacrylshikonin has significant antitumor effects on hepatocellular carcinoma both in vitro and in vivo.
    Planta Med. 2004 Jan;70(1):23-8.
    Impairment of vascular function of rat thoracic aorta in an endothelium-dependent manner by shikonin/alkannin and derivatives isolated from roots of Macrotomia euchroma.[Pubmed: 14765288 ]

    METHODS AND RESULTS:
    The effects of a naphthoquinone analogue, shikonin/alkannin (SA) and derivatives (acetylshikonin and beta,beta-Dimethylacrylshikonin), on vascular reactivity were studied with isolated rat aortic rings. At lower concentrations, SA and its derivatives concentration-dependently inhibit the agonist-induced (acetylcholine and histamine) relaxation in PE precontracted aorta in an endothelium-dependent manner with IC (50) values ranging from 0.2 to 1.5 microM. In addition to the effect on agonist-induced vasorelaxation, the Ca (2+) ionophore A23187-induced vasorelaxation was also inhibited or reversed by SA. However, SA had no effect on sodium nitroprusside-induced (guanylate cyclase activator) vasorelaxation. These data suggested that SA and its derivatives might be acting as inhibitors of nitric oxide synthesis in endothelium. At a concentration greater than 10 microM, SA induced contraction of intact but not denuded aorta which could be inhibited by prior treatment with indomethacin, a cyclooxygenase inhibitor.
    CONCLUSIONS:
    In summary, the results from this study showed that SA and its derivatives inhibited agonist-induced relaxation at lower concentrations and induced vasocontraction at higher concentrations. All the effects seen with SA were endothelium-dependent, however, through different mechanisms.
    In vivo:
    Biochem Pharmacol. 2012 Aug 15;84(4):507-12.
    β,β-Dimethylacrylshikonin exerts antitumor activity via Notch-1 signaling pathway in vitro and in vivo.[Pubmed: 22634048]
    Dimethylacrylshikonin (DA) is a major component of Radix Lithospermum erythrorhizon and has various biological activities.We have investigated the inhibitory effect of Dimethylacrylshikonin on the growth of hepatocellular carcinoma in vitro and in vivo. Notch signaling plays a critical role in maintaining the balance between cell proliferation, differentiation and apoptosis. Hence, perturbed Notch signaling may contribute to tumorigenesis.
    METHODS AND RESULTS:
    In the present study, we evaluated whether Dimethylacrylshikonin could be an effective inhibitor on cell growth in human gastric cancer cell line, and also the molecular mechanisms. Using multiple cellular and molecular approaches such as MTT assay, colony formation assay, DAPI staining, flow cytometry, real-time PCR and Western blot analysis, we found that Dimethylacrylshikonin inhibited cell growth in a dose- and time-dependent manner. Biochemical analysis revealed the involvement of cell cycle regulated proteins in DA-mediated of G₀-G₁ arrest of SGC-7901 cells. Furthermore, Dimethylacrylshikonin treatment led to reduced Notch-1 activation, expression of Jagged-1 and its downstream target Hes-1 in vitro and in vivo.
    CONCLUSIONS:
    Our data demonstrated that Dimethylacrylshikonin is a potent inhibitor of progression of gastric cancer cells, which could be due to attenuation of Notch-1. We also suggest that Dimethylacrylshikonin could be further developed as a potential therapeutic agent for the treatment of gastric cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.6999 mL 13.4993 mL 26.9986 mL 53.9971 mL 67.4964 mL
    5 mM 0.54 mL 2.6999 mL 5.3997 mL 10.7994 mL 13.4993 mL
    10 mM 0.27 mL 1.3499 mL 2.6999 mL 5.3997 mL 6.7496 mL
    50 mM 0.054 mL 0.27 mL 0.54 mL 1.0799 mL 1.3499 mL
    100 mM 0.027 mL 0.135 mL 0.27 mL 0.54 mL 0.675 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异戊酰紫草素; Isovalerylshikonin CFN95222 52387-14-1 C21H24O6 = 372.4 10mg QQ客服:215959384
    Beta-羟基异戊酰紫草素; Beta-Hydroxyisovalerylshikonin CFN93028 7415-78-3 C21H24O7 = 388.42 5mg QQ客服:215959384
    乙酰氧基异戊酰阿卡宁; Acetoxyisovalerylalkannin CFN92025 69091-17-4 C23H26O8 = 430.5 20mg QQ客服:2159513211
    黄钟花醌; Lapachol CFN97403 84-79-7 C15H14O3 = 242.3 20mg QQ客服:1413575084
    去氧紫草素; Deoxyshikonin CFN92024 43043-74-9 C16H16O4 = 272.3 20mg QQ客服:1148253675
    紫草素; Shikonine CFN92622 517-89-5 C16H16O5 = 288.3 20mg QQ客服:1148253675
    紫草素; Shikonin CFN99907 517-88-4 C16H16O5 = 288.31 20mg QQ客服:1148253675
    乙酰紫草素; Acetylshikonin CFN90308 54984-93-9 C18H18O6 = 330.33 20mg QQ客服:215959384
    异丁酰紫草; Isobutylshikonin CFN92023 52438-12-7 C20H22O6 = 358.4 10mg QQ客服:215959384
    β,β-二甲基丙烯酰紫草素; Dimethylacrylshikonin CFN90164 24502-79-2 C21H22O6 = 370.39 20mg QQ客服:3257982914

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