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    赤芝二醇

    Lucidadiol

    赤芝二醇
    产品编号 CFN96840
    CAS编号 252351-95-4
    分子式 = 分子量 C30H48O3 = 456.71
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruitbody of Ganoderma pfeifferi.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    赤芝二醇 CFN96840 252351-95-4 1mg QQ客服:2932563308
    赤芝二醇 CFN96840 252351-95-4 5mg QQ客服:2932563308
    赤芝二醇 CFN96840 252351-95-4 10mg QQ客服:2932563308
    赤芝二醇 CFN96840 252351-95-4 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sapienza University of Rome (Italy)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • University of Liège (Belgium)
  • Nanjing University of Chinese Medicine (China)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Universidad de Buenos Aires (Argentina)
  • Worcester Polytechnic Institute (USA)
  • Medizinische Universit?t Wien (Austria)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • VIT University (India)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Universidad de La Salle (Mexico)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Molecules.2016, 21(6)
  • Acta Chromatographica2016, 29(3)
  • J Ethnopharmacol.2017, 198:205-213
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • Cell.2018, 172(1-2):249-261
  • Int J Mol Sci.2018, 19(2)
  • Food and Fermentation Industries2018, 44(371)
  • Biochem Biophys Res Commun.2018, 505(4):1148-1153
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • Front Aging Neurosci.2019, 11:230
  • Microb Pathog.2019, 131:128-134
  • Molecules.2019, 25(1):E103
  • Environ Toxicol.2019, 34(12):1354-1362
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Pest Manag Sci.2019, 75(9):2530-2541
  • TCI CO.2019, US20190151281A1
  • J Cell Physiol.2020, 10.1002
  • Pharmacological Reports2020, 1-9
  • Internoational J of Toxicology2020, 10.1177.
  • J Ethnopharmacol.2020, 269:113752.
  • Korean Herb. Med. Inf.2020, 8(2):243-254.
  • Phytochemistry.2021, 181:112539.
  • ...
  • 生物活性
    Description: Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, it also possesses inhibitory activity against acetylcholinesterase (AChE) with the percentage inhibition at 100 uM. Lucidadiol shows antiviral activity against influenza virus type A and HSV type 1.
    Targets: AChR | HSV | Butyrylcholinesterase
    In vitro:
    Phytochemistry. 2015 Feb;110:133-9.
    Lanostanoids with acetylcholinesterase inhibitory activity from the mushroom Haddowia longipes.[Pubmed: 25577284 ]

    METHODS AND RESULTS:
    Nine lanostanoids, together with nine known ones, were isolated from the ethyl acetate extract of the fruiting bodies of the mushroom Haddowia longipes. Their structures were elucidated as 11-oxo-ganoderiol D, lanosta-8-en-7,11-dioxo-3β-acetyloxy-24,25,26-trihydroxy, lanosta-8-en-7-oxo-3β-acetyloxy-11β,24,25,26-tetrahydroxy, lanosta-7,9(11)-dien-3β-acetyloxy-24,25,26-trihydroxy, lanosta-7,9(11)-dien-3β-acetyloxy-24,26-dihydroxy-25-methoxy, 11-oxo-Lucidadiol, 11β-hydroxy-Lucidadiol, lucidone H and lanosta-7,9(11),24E-trien-3β-acetyloxy-26,27-dihydroxy by analysing their 1D/2D NMR and MS spectra.
    CONCLUSIONS:
    In addition, bioassays of inhibitory activity against acetylcholinesterase (AChE) of all compounds showed that thirteen compounds possessed inhibitory activity against AChE with the percentage inhibition ranging from 10.3% to 42.1% when tested at 100 μM.
    Bioorg Med Chem Lett. 2011 Nov 1;21(21):6603-7.
    Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum.[Pubmed: 21924611 ]

    METHODS AND RESULTS:
    Two new lanostane triterpenes, named methyl ganoderate A acetonide (1) and n-butyl ganoderate H (2), were isolated from the fruiting bodies of Ganoderma lucidum together with 16 known compounds (3-18). Extensive spectroscopic and chemical studies established the structures of these compounds as methyl 7β,15α-isopropylidenedioxy-3,11,23-trioxo-5α-lanost-8-en-26-oate (1) and n-butyl 12β-acetoxy-3β-hydroxy-7,11,15,23-tetraoxo-5α-lanost-8-en-26-oate (2). Because new compounds exhibiting specific anti-acetylcholinesterase activity are being sought as possible drug candidates for the treatment of Alzheimer's and related neurodegenerative diseases, compounds 1-18 were examined for their inhibitory activities against acetylcholinesterase and butyrylcholinesterase. All of the compounds exhibited moderate acetylcholinesterase-inhibitory activity, with IC(50) values ranging from 9.40 to 31.03μM. In contrast, none of the compounds except Lucidadiol (13) and lucidenic acid N (14) exhibited butyrylcholinesterase-inhibitory activity at concentrations up to 200μM.
    CONCLUSIONS:
    These results indicate that these lanostane triterpenes are preferential inhibitors of acetylcholinesterase and may be suitable drug candidates.
    Fitoterapia. 2003 Feb;74(1-2):177-80.
    Antiviral lanostanoid triterpenes from the fungus Ganoderma pfeifferi.[Pubmed: 12628419]
    Ganodermadiol, lucidadiol and applanoxidic acid G were isolated as first triterpenes from the European Basidiomycete Ganoderma pfeifferi. The compounds show antiviral activity against influenza virus type A and HSV type 1.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1896 mL 10.9479 mL 21.8957 mL 43.7915 mL 54.7393 mL
    5 mM 0.4379 mL 2.1896 mL 4.3791 mL 8.7583 mL 10.9479 mL
    10 mM 0.219 mL 1.0948 mL 2.1896 mL 4.3791 mL 5.4739 mL
    50 mM 0.0438 mL 0.219 mL 0.4379 mL 0.8758 mL 1.0948 mL
    100 mM 0.0219 mL 0.1095 mL 0.219 mL 0.4379 mL 0.5474 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝醇A; Ganoderol A CFN99065 104700-97-2 C30H46O2 = 438.7 5mg QQ客服:2056216494
    灵芝醇F; Ganoderiol F CFN99244 114567-47-4 C30H46O3 = 454.7 5mg QQ客服:2159513211
    灵芝萜酮二醇 ; Ganodermanondiol CFN99085 107900-76-5 C30H48O3 = 456.7 5mg QQ客服:2159513211
    灵芝醇A; Ganoderiol A CFN80461 106518-61-0 C30H50O4 = 474.37 5mg QQ客服:2159513211
    灵芝马酮; Ganodermanontriol CFN99077 106518-63-2 C30H48O4 = 472.7 5mg QQ客服:1413575084
    Lucialdehyde A; Lucialdehyde A CFN90304 420781-84-6 C30H46O2 = 438.69 5mg QQ客服:2056216494
    灵芝醛A; Ganoderal A CFN90306 104700-98-3 C30H44O2 = 436.68 5mg QQ客服:1413575084
    灵芝酮A; Ganoderone A CFN90303 873061-79-1 C30H48O3 = 456.70 5mg QQ客服:2159513211
    赤芝二醇; Lucidadiol CFN96840 252351-95-4 C30H48O3 = 456.71 5mg QQ客服:2159513211
    Lucidal; Lucidal CFN92234 252351-96-5 C30H46O3 = 454.7 5mg QQ客服:3257982914

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