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  • 灵芝马酮

    Ganodermanontriol

    灵芝马酮
    产品编号 CFN99077
    CAS编号 106518-63-2
    分子式 = 分子量 C30H48O4 = 472.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝马酮 CFN99077 106518-63-2 1mg QQ客服:1148253675
    灵芝马酮 CFN99077 106518-63-2 5mg QQ客服:1148253675
    灵芝马酮 CFN99077 106518-63-2 10mg QQ客服:1148253675
    灵芝马酮 CFN99077 106518-63-2 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universitas islam negeri Jakarta (Indonesia)
  • University of Illinois (USA)
  • John Innes Centre (United Kingdom)
  • University of Madras (India)
  • University of Canterbury (New Zealand)
  • The Ohio State University (USA)
  • Universiti Malaysia Pahang (Malaysia)
  • University of the Basque Country (Spain)
  • Universiti Sains Malaysia (Malaysia)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • University of Zurich (Switzerland)
  • University of Pretoria (South Africa)
  • Kyung Hee University (Korea)
  • Donald Danforth Plant Science Center (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(11):14105-21
  • Anticancer Res.2014, 34(7):3505-9
  • New Zealand J. Forestry Sci.2014, 44:17
  • Ind Crops Prod.2014, 62:173-178
  • Exp Parasitol.2015, 153:160-4
  • Auburn University2015, 1-58
  • J Breast Cancer.2015, 18(2):112-118
  • Arch Pharm Res.2015, 38(6):1080-9
  • J Chromatogr Sci.2015, 53(5):824-9
  • Oncotarget.2015, 6(31):30831-49
  • Acta Biochim Pol.2015, 62(2):253-8
  • Molecules.2017, 22(2)
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • J Nat Med.2017, 71(2):380-388
  • Food Quality and Safety2018, 2:213-219
  • Life Sci.2018, 209:498-506
  • Sci Adv.2018, 4(10)
  • Pathogens.2018, 7(3):E62
  • Int J Biol Macromol.2019, 126:653-661
  • Oncol Rep.2019, 41(4):2453-2463
  • Int J Oncol.2019, 55(1):320-330
  • J Pharmaceut Biomed2020, 182:113110
  • Pharmacological Reports2020, 1-9
  • ...
  • 生物活性
    Description: Ganodermanontriol has anti-cancer, hepatoprotective, anti-inflammatory, and antioxidative activities, it also shows a strong anticomplement activity against the classical pathway (CP) of the complement system with IC(50) values of 17.2 microM. Ganodermanontriol is active as an anti-HIV-1 agent with an inhibitory concentration of 7.8 micrograms ml-1.It has a wide spectrum of targets including HO-1, PI3K/Akt and p38 kinases.
    Targets: PI3K | Akt | p38MAPK | HIV | HO-1
    In vitro:
    J Ethnopharmacol. 2013 Dec 12;150(3):875-85.
    In vitro and in vivo hepatoprotective effect of ganodermanontriol against t-BHP-induced oxidative stress.[Pubmed: 24140584]
    Ganoderma lucidum (Fr.) Karst. (Ganodermataceae) is a mushroom which is used as a traditional remedy in the treatment of human diseases such as hepatitis, liver disorders, hypercholesterolemia, arthritis, bronchitis and tumorigenic diseases.
    METHODS AND RESULTS:
    This study targets the evaluation of hepatoprotective activity of ganodermanontriol, a sterol isolated from Ganoderma lucidum, and the investigation of its mechanism of action in Hepa1c1c7 and murine liver cells upon tert-butyl hydroperoxide (t-BHP)-induced inflammation. t-BHP was utilized to stimulate an anti-inflammatory reaction in the hepatic cell lines and murine hepatic tissue examined. Western blot and reverse transcription-quantitative polymerase chain reaction (RT-PCR) were used to estimate the expression of ganodermanontriol (GDT)-induced proteins, including heme oxidase-1 (HO-1) and mitogen-activated protein kinases (MAPKs) as well as the corresponding mRNA. Luciferase assays were conducted to evaluate the interaction between NF-E2-related factor-2 (Nrf-2), the antioxidant response element (ARE), and the promoter region of the HO-1 gene and subsequent gene expression. Biochemical markers for hepatotoxicity were monitored to assess whether GDT protected the cells from the t-BHP-mediated oxidative stimuli. GDT induced HO-1 expression via the activation of Nrf-2 nuclear translocation and the subsequent transcription of the HO-1 gene in vitro and in vivo, which seemed to be regulated by phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) and p38 signaling pathways. GDT exhibited in vitro and in vivo hepatoprotective activity as determined by the lowered levels of hepatic enzymes and malondialdehydes and the elevated glutathione levels.
    CONCLUSIONS:
    This study validates the ethnopharmacological application of Ganoderma lucidum as a treatment for hepatic disorders. GDT induced in vitro and in vivo anti-inflammatory activity in t-BHP-damaged hepatic cells through the expression of HO-1, and in which PI3K/Akt and p38 kinases are involved. Our study motivates further research in the exploration of potent hepatoprotective agents from Ganoderma lucidum.
    Phytother. Res., 1999, 13(6):529–31.
    Triterpene antioxidants from ganoderma lucidum.[Pubmed: 10479768]
    Ganoderma lucidum was studied for its antioxidative activity by bioassay guided isolation in conjunction with in vitro tests.
    METHODS AND RESULTS:
    The powdered crude drug was treated with boiling water and the aqueous extract (Ex1) was further separated to obtain terpene and polysaccharide fractions. The two fractions and Ex1 were screened for their antioxidative effect against pyrogallol induced erythrocyte membrane oxidation and Fe (II)-ascorbic acid induced lipid peroxidation. All tested samples showed antioxidative activities in a dose dependent manner and the terpene fraction was found to possess the highest effect compared with the others.
    CONCLUSIONS:
    Chemical isolation of the terpene fraction resulted in the detection of ganoderic acids A, B, C and D, lucidenic acid B and ganodermanontriol as major ingredients.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1155 mL 10.5775 mL 21.1551 mL 42.3101 mL 52.8877 mL
    5 mM 0.4231 mL 2.1155 mL 4.231 mL 8.462 mL 10.5775 mL
    10 mM 0.2116 mL 1.0578 mL 2.1155 mL 4.231 mL 5.2888 mL
    50 mM 0.0423 mL 0.2116 mL 0.4231 mL 0.8462 mL 1.0578 mL
    100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.4231 mL 0.5289 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝醇A; Ganoderol A CFN99065 104700-97-2 C30H46O2 = 438.7 5mg QQ客服:1148253675
    灵芝醇F; Ganoderiol F CFN99244 114567-47-4 C30H46O3 = 454.7 5mg QQ客服:2932563308
    灵芝萜酮二醇 ; Ganodermanondiol CFN99085 107900-76-5 C30H48O3 = 456.7 5mg QQ客服:2932563308
    灵芝醇A; Ganoderiol A CFN80461 106518-61-0 C30H50O4 = 474.37 5mg QQ客服:2159513211
    灵芝马酮; Ganodermanontriol CFN99077 106518-63-2 C30H48O4 = 472.7 5mg QQ客服:2159513211
    Lucialdehyde A; Lucialdehyde A CFN90304 420781-84-6 C30H46O2 = 438.69 5mg QQ客服:215959384
    灵芝醛A; Ganoderal A CFN90306 104700-98-3 C30H44O2 = 436.68 5mg QQ客服:215959384
    灵芝酮A; Ganoderone A CFN90303 873061-79-1 C30H48O3 = 456.70 5mg QQ客服:2932563308
    赤芝二醇; Lucidadiol CFN96840 252351-95-4 C30H48O3 = 456.71 5mg QQ客服:2932563308
    Lucidal; Lucidal CFN92234 252351-96-5 C30H46O3 = 454.7 5mg QQ客服:2159513211

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