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    Ganoderol A

    产品编号 CFN99065
    CAS编号 104700-97-2
    分子式 = 分子量 C30H46O2 = 438.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruiting body of Ganoderma lucidum
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝醇A CFN99065 104700-97-2 1mg QQ客服:2056216494
    灵芝醇A CFN99065 104700-97-2 5mg QQ客服:2056216494
    灵芝醇A CFN99065 104700-97-2 10mg QQ客服:2056216494
    灵芝醇A CFN99065 104700-97-2 20mg QQ客服:2056216494
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  • University of Pretoria (South Africa)
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  • 生物活性
    Description: Ganoderol A has significant anti-inflammatory activity and protection against UVA damage. it has an inhibitory effect on angiotensin converting enzyme activity and cholesterol biosynthesis.
    In vitro:
    Trop. J. Pharm. Res., 2015, 14(3):412-21.
    In vitro Protective Effect of Ganoderol A Isolated from Ganadermalucidum Against Ultraviolet A Radiation and its Anti-inflammatory Properties[Reference: WebLink]
    Purpose: To evaluate the ultraviolet A (UVA) protection and anti-inflammatory activity of ganoderol A extracted from Ganodermalucidum.
    Methods: The cytotoxicity and in vitro protective effect of ganoderol A against UVA damage were evaluated by MTT assay. Apoptosis and cell-cycle arrest of NIH/3T3 fibroblast cells were assayed by fluorescence-activated cell sorting (FCS). Expression of monocyte chemotactic protein-1 (MCP-1) and inducible nitric oxide synthase (iNOS) were determined using quantitative real-time polymerase chain reaction (qPCR). Results: The results indicate that the maximal non-toxic concentration of ganoderol A in NIH/3T3 cells and RAW 264.7 macrophages was 50 and 25 μg/mL respectively. DNA in the tails and tail length decreased by 55 and 70%, respectively, in the group pretreated with ganoderol A compared with the UVA-treated group. G1 phase cells decreased by 23%, whereas the number of apoptotic cells returned to normal. The expression of MCP-1 and iNOS declined to 60 and 15%, respectively, compared with LPS-stimulated group.
    Conclusion: Ganoderol A has significant anti-inflammatory activity and protection against UVA damage, thus suggesting that the compound is a candidate for the development of a suitable product to protect skin from UV-induced photoaging.
    In vivo:
    Appl Environ Microbiol. 2005 Jul;71(7):3653-8.
    Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.[Pubmed: 16000773 ]
    Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi and has been used extensively in traditional Chinese medicine.
    We report the isolation and identification of the 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and ganoderic acid Y and their biological effects on cholesterol synthesis in a human hepatic cell line in vitro. We also investigated the site of inhibition in the cholesterol synthesis pathway. We found that these oxygenated sterols from G. lucidum inhibited cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol. By incorporation of 24,25-dihydro-[24,25-3H2]lanosterol and [3-3H]lathosterol in the presence of ganoderol A, we determined that the point of inhibition of cholesterol synthesis is between lanosterol and lathosterol.
    These results demonstrate that the lanosterol 14alpha-demethylase, which converts 24,25-dihydrolanosterol to cholesterol, can be inhibited by the 26-oxygenosterols from G. lucidum. These 26-oxygenosterols could lead to novel therapeutic agents that lower blood cholesterol.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2795 mL 11.3973 mL 22.7946 mL 45.5892 mL 56.9866 mL
    5 mM 0.4559 mL 2.2795 mL 4.5589 mL 9.1178 mL 11.3973 mL
    10 mM 0.2279 mL 1.1397 mL 2.2795 mL 4.5589 mL 5.6987 mL
    50 mM 0.0456 mL 0.2279 mL 0.4559 mL 0.9118 mL 1.1397 mL
    100 mM 0.0228 mL 0.114 mL 0.2279 mL 0.4559 mL 0.5699 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    赤芝二醇; Lucidadiol CFN96840 252351-95-4 C30H48O3 = 456.71 5mg QQ客服:1413575084
    Lucidal; Lucidal CFN92234 252351-96-5 C30H46O3 = 454.7 5mg QQ客服:2932563308
    Lucialdehyde B; Lucialdehyde B CFN90305 480439-84-7 C30H44O3 = 452.67 5mg QQ客服:3257982914
    Lucidumol A; Lucidumol A CFN95059 217476-73-8 C30H48O4 = 472.7 5mg QQ客服:1413575084
    灵芝醇A; Ganoderol A CFN99065 104700-97-2 C30H46O2 = 438.7 5mg QQ客服:3257982914
    灵芝醇F; Ganoderiol F CFN99244 114567-47-4 C30H46O3 = 454.7 5mg QQ客服:2932563308
    灵芝萜酮二醇 ; Ganodermanondiol CFN99085 107900-76-5 C30H48O3 = 456.7 5mg QQ客服:1413575084
    灵芝醇A; Ganoderiol A CFN80461 106518-61-0 C30H50O4 = 474.37 5mg QQ客服:1457312923
    灵芝马酮; Ganodermanontriol CFN99077 106518-63-2 C30H48O4 = 472.7 5mg QQ客服:1413575084
    Lucialdehyde A; Lucialdehyde A CFN90304 420781-84-6 C30H46O2 = 438.69 5mg QQ客服:2159513211





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