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    灵芝醇A

    Ganoderol A

    灵芝醇A
    产品编号 CFN99065
    CAS编号 104700-97-2
    分子式 = 分子量 C30H46O2 = 438.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruiting body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝醇A CFN99065 104700-97-2 1mg QQ客服:2056216494
    灵芝醇A CFN99065 104700-97-2 5mg QQ客服:2056216494
    灵芝醇A CFN99065 104700-97-2 10mg QQ客服:2056216494
    灵芝醇A CFN99065 104700-97-2 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Pretoria (South Africa)
  • Medical University of Gdansk (Poland)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Wroclaw Medical University (Poland)
  • Universidad Industrial de Santander (Colombia)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Padjajaran (Indonesia)
  • Chulalongkorn University (Thailand)
  • Lodz University of Technology (Poland)
  • University of Eastern Finland (Finland)
  • Universidad Miguel Hernández (Spain)
  • University of Canterbury (New Zealand)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Universidad de Antioquia (Colombia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytochem Anal.2013, 24(5):493-503
  • J. of Agricultural Science2015, 1916-9760
  • Molecules.2016, 21(6)
  • Universidade Estadual Paulista2017, 11449
  • Int J Mol Sci.2017, 18(5)
  • Sci Rep.2017, 7:40345
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Int J Mol Sci.2019, 20(11):E2734
  • Int J Mol Med.2019, 43(6):2516-2522
  • Phytomedicine.2019, 57:95-104
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Food Sci Nutr.2019, 8(1):246-256
  • Metabolites.2019, 9(11):E271
  • Food Analytical Methods2020, 1-10
  • Front Immunol.2020, 11:598556.
  • Int J Mol Sci.2020, 21(24):9369.
  • Int J Mol Sci.2020, 21(7):2530.
  • Molecules.2020, 25(17):3783.
  • Biomed Sci Letters.2020, 26:319-326
  • Chem Biol Interact.2020, 328:109200.
  • Biomedicines.2020, 8(11):486.
  • Plants (Basel).2020, 9(11):1422.
  • ...
  • 生物活性
    Description: Ganoderol A has significant anti-inflammatory activity and protection against UVA damage. it has an inhibitory effect on angiotensin converting enzyme activity and cholesterol biosynthesis.
    In vitro:
    Trop. J. Pharm. Res., 2015, 14(3):412-21.
    In vitro Protective Effect of Ganoderol A Isolated from Ganadermalucidum Against Ultraviolet A Radiation and its Anti-inflammatory Properties[Reference: WebLink]
    Purpose: To evaluate the ultraviolet A (UVA) protection and anti-inflammatory activity of ganoderol A extracted from Ganodermalucidum.
    METHODS AND RESULTS:
    Methods: The cytotoxicity and in vitro protective effect of ganoderol A against UVA damage were evaluated by MTT assay. Apoptosis and cell-cycle arrest of NIH/3T3 fibroblast cells were assayed by fluorescence-activated cell sorting (FCS). Expression of monocyte chemotactic protein-1 (MCP-1) and inducible nitric oxide synthase (iNOS) were determined using quantitative real-time polymerase chain reaction (qPCR). Results: The results indicate that the maximal non-toxic concentration of ganoderol A in NIH/3T3 cells and RAW 264.7 macrophages was 50 and 25 μg/mL respectively. DNA in the tails and tail length decreased by 55 and 70%, respectively, in the group pretreated with ganoderol A compared with the UVA-treated group. G1 phase cells decreased by 23%, whereas the number of apoptotic cells returned to normal. The expression of MCP-1 and iNOS declined to 60 and 15%, respectively, compared with LPS-stimulated group.
    CONCLUSIONS:
    Conclusion: Ganoderol A has significant anti-inflammatory activity and protection against UVA damage, thus suggesting that the compound is a candidate for the development of a suitable product to protect skin from UV-induced photoaging.
    In vivo:
    Appl Environ Microbiol. 2005 Jul;71(7):3653-8.
    Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.[Pubmed: 16000773 ]
    Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi and has been used extensively in traditional Chinese medicine.
    METHODS AND RESULTS:
    We report the isolation and identification of the 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and ganoderic acid Y and their biological effects on cholesterol synthesis in a human hepatic cell line in vitro. We also investigated the site of inhibition in the cholesterol synthesis pathway. We found that these oxygenated sterols from G. lucidum inhibited cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol. By incorporation of 24,25-dihydro-[24,25-3H2]lanosterol and [3-3H]lathosterol in the presence of ganoderol A, we determined that the point of inhibition of cholesterol synthesis is between lanosterol and lathosterol.
    CONCLUSIONS:
    These results demonstrate that the lanosterol 14alpha-demethylase, which converts 24,25-dihydrolanosterol to cholesterol, can be inhibited by the 26-oxygenosterols from G. lucidum. These 26-oxygenosterols could lead to novel therapeutic agents that lower blood cholesterol.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2795 mL 11.3973 mL 22.7946 mL 45.5892 mL 56.9866 mL
    5 mM 0.4559 mL 2.2795 mL 4.5589 mL 9.1178 mL 11.3973 mL
    10 mM 0.2279 mL 1.1397 mL 2.2795 mL 4.5589 mL 5.6987 mL
    50 mM 0.0456 mL 0.2279 mL 0.4559 mL 0.9118 mL 1.1397 mL
    100 mM 0.0228 mL 0.114 mL 0.2279 mL 0.4559 mL 0.5699 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    赤芝二醇; Lucidadiol CFN96840 252351-95-4 C30H48O3 = 456.71 5mg QQ客服:1413575084
    Lucidal; Lucidal CFN92234 252351-96-5 C30H46O3 = 454.7 5mg QQ客服:2932563308
    Lucialdehyde B; Lucialdehyde B CFN90305 480439-84-7 C30H44O3 = 452.67 5mg QQ客服:3257982914
    Lucidumol A; Lucidumol A CFN95059 217476-73-8 C30H48O4 = 472.7 5mg QQ客服:1413575084
    灵芝醇A; Ganoderol A CFN99065 104700-97-2 C30H46O2 = 438.7 5mg QQ客服:3257982914
    灵芝醇F; Ganoderiol F CFN99244 114567-47-4 C30H46O3 = 454.7 5mg QQ客服:2932563308
    灵芝萜酮二醇 ; Ganodermanondiol CFN99085 107900-76-5 C30H48O3 = 456.7 5mg QQ客服:1413575084
    灵芝醇A; Ganoderiol A CFN80461 106518-61-0 C30H50O4 = 474.37 5mg QQ客服:1457312923
    灵芝马酮; Ganodermanontriol CFN99077 106518-63-2 C30H48O4 = 472.7 5mg QQ客服:1413575084
    Lucialdehyde A; Lucialdehyde A CFN90304 420781-84-6 C30H46O2 = 438.69 5mg QQ客服:2159513211

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