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  • 灵芝醇F

    Ganoderiol F

    灵芝醇F
    产品编号 CFN99244
    CAS编号 114567-47-4
    分子式 = 分子量 C30H46O3 = 454.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝醇F CFN99244 114567-47-4 1mg QQ客服:3257982914
    灵芝醇F CFN99244 114567-47-4 5mg QQ客服:3257982914
    灵芝醇F CFN99244 114567-47-4 10mg QQ客服:3257982914
    灵芝醇F CFN99244 114567-47-4 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • St. Jude Children Research Hospital (USA)
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  • Deutsches Krebsforschungszentrum (Germany)
  • Helmholtz Zentrum München (Germany)
  • John Innes Centre (United Kingdom)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Research International2016, 106-113
  • Korean J. of Food Sci. and Tech2016, 172-177
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • Acta horticulturae2017, 1158:257-268
  • Nat Prod Commun.2017, 12(5):771-778
  • Org Biomol Chem.2017, 15(31):6483-6492
  • Biol Pharm Bull.2017, 40(6):797-806
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Br J Pharmacol.2018, 175(6):902-923
  • BMC Complement Altern Med.2018, 18(1):303
  • Life Sci.2018, 209:498-506
  • Nat Prod Sci.2018, 24(2):109-114
  • Biofactors.2018, 44(2):168-179
  • Phytother Res.2019, 10.1002
  • Front Pharmacol.2019, 10:1226
  • J of Essential Oil Research2019, 1677272
  • Pharmacol Rep.2019, 71(2):289-298
  • Planta Med.2019, 85(3):217-224
  • Sci Rep.2019, 9(1):4646
  • J Cell Physiol.2020, 10.1002
  • Industrial Crops and Products2020, 146:112186
  • Pharmacological Reports2020, 1-9
  • ...
  • 生物活性
    Description: Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM. It induced HO-1 expression, activation of the mitogen-activated protein kinase EKR and up-regulation of cyclin-dependent kinase inhibitor p16 and suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) production.
    Targets: Androgen Receptor | HIV | NO | HO-1
    In vitro:
    Toxicol Appl Pharmacol. 2014 Nov 1;280(3):434-42.
    Anti-inflammatory and heme oxygenase-1 inducing activities of lanostane triterpenes isolated from mushroom Ganoderma lucidum in RAW264.7 cells.[Pubmed: 25239868]
    Ganoderma lucidum is a popular medicinal mushroom used in traditional medicine for preventing or treating a variety of diseases.
    METHODS AND RESULTS:
    In the present study, we investigated the anti-inflammatory and heme oxygenase (HO)-1 inducing effects of 12 lanostane triterpenes from G. lucidum in RAW264.7 cells. Of these, seven triterpenes, butyl lucidenateE2, butyl lucidenateD2 (GT-2), butyl lucidenate P, butyl lucidenateQ, Ganoderiol F, methyl ganodenate J and butyl lucidenate N induced HO-1 expression and suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) production. Inhibiting HO-1 activity abrogated the inhibitory effects of these triterpenes on the production of NO in LPS-stimulated RAW264.7 cells, suggesting the involvement of HO-1 in the anti-inflammatory effects of these triterpenes. We further studied the anti-inflammatory and HO-1 inducing effects of GT-2. Mitogen-activated protein kinase inhibitors or N-acetylcysteine, an antioxidant, did not suppress GT-2-mediated HO-1 induction; however, LY294002, a phosphoinositide 3-kinase (PI3K) inhibitor, blocked GT-2-induced HO-1 mRNA and protein expression. GT-2 increased nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) and knockdown of Nrf2 by small interfering RNA blocked GT-2-mediated HO-1 induction, suggesting that GT-2 induced HO-1 expression via the PI3K/AKT-Nrf2 pathway. Consistent with the notion that HO-1 has anti-inflammatory properties, GT-2 inhibited the production of tumor necrosis factor-α and interleukin-6, as well as inducible nitric oxide synthase and cyclooxygenase-2 expression.
    CONCLUSIONS:
    These findings suggest that HO-1 inducing activities of these lanostane triterpenes may be important in the understanding of a novel mechanism for the anti-inflammatory activity of G. lucidum.
    In vivo:
    Chem Pharm Bull (Tokyo). 2009 Oct;57(10):1076-80.
    Anti-human immunodeficiency virus-1 protease activity of new lanostane-type triterpenoids from Ganoderma sinense.[Pubmed: 19801861]
    Five new highly oxygenated lanostane-type triterpenoids [ganoderic acid GS-1 (1), ganoderic acid GS-2 (2), ganoderic acid GS-3 (3), 20(21)-dehydrolucidenic acid N (4) and 20-hydroxylucidenic acid A (5)] were isolated from the fruiting body of Ganoderma sinense, together with known compounds including 6 triterpenoids and 3 sterols.
    METHODS AND RESULTS:
    The structures of the new triterpenoids determined by spectroscopic means including 2D NMR were 7beta-hydroxy-3,11,15-trioxo-lanosta-8,24(E)-dien-26-oic acid (1), 7beta,15alpha-dihydroxy-3,11-dioxo-lanosta-8,24(E)-dien-26-oic acid (2), 12beta-acetoxy-3beta,7beta-dihydroxy-11,15-dioxo-lanosta-8,24(E)-dien-26-oic acid (3), 3beta,7beta-dihydroxy-11,15-dioxo-25,26,27-trinorlanosta-8,20-dien-24-oic acid (4), and 7beta,20xi-dihydroxy-3,11,15-trioxo-25,26,27-trinorlanost-8-en-24-oic acid (5), respectively.
    CONCLUSIONS:
    Among these, ganoderic acid GS-2, 20-hydroxylucidenic acid N, 20(21)-dehydrolucidenic acid N and ganoderiol F inhibited human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1993 mL 10.9963 mL 21.9925 mL 43.985 mL 54.9813 mL
    5 mM 0.4399 mL 2.1993 mL 4.3985 mL 8.797 mL 10.9963 mL
    10 mM 0.2199 mL 1.0996 mL 2.1993 mL 4.3985 mL 5.4981 mL
    50 mM 0.044 mL 0.2199 mL 0.4399 mL 0.8797 mL 1.0996 mL
    100 mM 0.022 mL 0.11 mL 0.2199 mL 0.4399 mL 0.5498 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Lucidal; Lucidal CFN92234 252351-96-5 C30H46O3 = 454.7 5mg QQ客服:3257982914
    Lucialdehyde B; Lucialdehyde B CFN90305 480439-84-7 C30H44O3 = 452.67 5mg QQ客服:3257982914
    Lucidumol A; Lucidumol A CFN95059 217476-73-8 C30H48O4 = 472.7 5mg QQ客服:2932563308
    灵芝醇A; Ganoderol A CFN99065 104700-97-2 C30H46O2 = 438.7 5mg QQ客服:1148253675
    灵芝醇F; Ganoderiol F CFN99244 114567-47-4 C30H46O3 = 454.7 5mg QQ客服:215959384
    灵芝萜酮二醇 ; Ganodermanondiol CFN99085 107900-76-5 C30H48O3 = 456.7 5mg QQ客服:2932563308
    灵芝醇A; Ganoderiol A CFN80461 106518-61-0 C30H50O4 = 474.37 5mg QQ客服:2159513211
    灵芝马酮; Ganodermanontriol CFN99077 106518-63-2 C30H48O4 = 472.7 5mg QQ客服:3257982914
    Lucialdehyde A; Lucialdehyde A CFN90304 420781-84-6 C30H46O2 = 438.69 5mg QQ客服:3257982914
    灵芝醛A; Ganoderal A CFN90306 104700-98-3 C30H44O2 = 436.68 5mg QQ客服:1148253675

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