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  • 灵芝醇A

    Ganoderiol A

    灵芝醇A
    产品编号 CFN80461
    CAS编号 106518-61-0
    分子式 = 分子量 C30H50O4 = 474.37
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝醇A CFN80461 106518-61-0 1mg QQ客服:3257982914
    灵芝醇A CFN80461 106518-61-0 5mg QQ客服:3257982914
    灵芝醇A CFN80461 106518-61-0 10mg QQ客服:3257982914
    灵芝醇A CFN80461 106518-61-0 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • China Medical University (Taiwan)
  • University of Bonn (Germany)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Complutense University of Madrid (Spain)
  • Universiti Sains Malaysia (Malaysia)
  • University of Toulouse (France)
  • Amity University (India)
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  • Universidad Miguel Hernández (Spain)
  • Hamdard University (India)
  • Kazusa DNA Research Institute (Japan)
  • University of Auckland (New Zealand)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Nicolaus Copernicus Uniwersity (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J. of Med. Plant Research.2013, 90-151
  • The Journal of Internal Korean Medicine2015, 36(4):486-497
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • J Drug Target.2016, 24:1-28
  • Acta Physiologiae Plantarum2016, 38:7
  • Pharm Biol.2016, 54(7):1255-62
  • Int J Mol Sci.2017, 18(12)
  • J Ethnopharmacol.2017, 198:87-90
  • J Ethnopharmacol.2017, 206:327-336
  • Food Chem.2017, 221:1135-1144
  • Sci Rep.2017, 7(1):3249
  • Plant J.2017, 90(3):535-546
  • J Ethnopharmacol.2018, 210:88-94
  • Food and Fermentation Industries2018, 44(371)
  • Oncology Letters2018, 4690-4696
  • Cell Death Dis.2019, 10(12):882
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • Journal of Functional Foods2019, 52:430-441
  • Planta Med.2019, 85(4):347-355
  • LWT-Food Sci Technol2020, 109163
  • J Ethnopharmacol.2020, 249:112396
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • Evid-Based Compl Alt2020, 7202519:13
  • ...
  • 生物活性
    Description: Ganoderiol A suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-Paxillin cascade pathway.
    Targets: Src
    In vitro:
    PLoS One. 2013 Oct 29;8(10):e76620.
    Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway.[Pubmed: 24204647 ]
    Cell adhesion, migration and invasion are critical steps for carcinogenesis and cancer metastasis. Ganoderma lucidum, also called Lingzhi in China, is a traditional Chinese medicine, which exhibits anti-proliferation, anti-inflammation and anti-metastasis properties.
    METHODS AND RESULTS:
    Herein, GAEE, G. lucidum extract mainly contains Ganoderiol A (GA), dihydrogenated GA and GA isomer, was shown to inhibit the abilities of adhesion and migration, while have a slight influence on that of invasion in highly metastatic breast cancer MDA-MB-231 cells at non-toxic doses. Further investigation revealed that GAEE decreased the active forms of focal adhesion kinase (FAK) and disrupted the interaction between FAK and SRC, which lead to deactivating of paxillin. Moreover, GAEE treatment downregulated the expressions of RhoA, Rac1, and Cdc42, and decreased the interaction between neural Wiskott-Aldrich Syndrome protein (N-WASP) and Cdc42, which impair cell migration and actin assembly.
    CONCLUSIONS:
    To our knowledge, this is the first report to show that G.lucidum triterpenoids could suppress cell migration and adhesion through FAK-SRC-paxillin signaling pathway. Our study also suggests that GAEE may be a potential agent for treatment of breast cancer.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1081 mL 10.5403 mL 21.0806 mL 42.1612 mL 52.7015 mL
    5 mM 0.4216 mL 2.1081 mL 4.2161 mL 8.4322 mL 10.5403 mL
    10 mM 0.2108 mL 1.054 mL 2.1081 mL 4.2161 mL 5.2701 mL
    50 mM 0.0422 mL 0.2108 mL 0.4216 mL 0.8432 mL 1.054 mL
    100 mM 0.0211 mL 0.1054 mL 0.2108 mL 0.4216 mL 0.527 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Lucidal; Lucidal CFN92234 252351-96-5 C30H46O3 = 454.7 5mg QQ客服:1148253675
    Lucialdehyde B; Lucialdehyde B CFN90305 480439-84-7 C30H44O3 = 452.67 5mg QQ客服:2932563308
    Lucidumol A; Lucidumol A CFN95059 217476-73-8 C30H48O4 = 472.7 5mg QQ客服:1148253675
    灵芝醇A; Ganoderol A CFN99065 104700-97-2 C30H46O2 = 438.7 5mg QQ客服:215959384
    灵芝醇F; Ganoderiol F CFN99244 114567-47-4 C30H46O3 = 454.7 5mg QQ客服:2932563308
    灵芝萜酮二醇 ; Ganodermanondiol CFN99085 107900-76-5 C30H48O3 = 456.7 5mg QQ客服:215959384
    灵芝醇A; Ganoderiol A CFN80461 106518-61-0 C30H50O4 = 474.37 5mg QQ客服:1148253675
    灵芝马酮; Ganodermanontriol CFN99077 106518-63-2 C30H48O4 = 472.7 5mg QQ客服:215959384
    Lucialdehyde A; Lucialdehyde A CFN90304 420781-84-6 C30H46O2 = 438.69 5mg QQ客服:1148253675
    灵芝醛A; Ganoderal A CFN90306 104700-98-3 C30H44O2 = 436.68 5mg QQ客服:1148253675

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