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  • 灵芝醇B

    • 灵芝醇B

    Ganoderol B

    灵芝醇B
    		产品编号 CFN99064
    CAS编号 104700-96-1
    分子式 = 分子量 C30H48O2 = 440.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruiting body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝醇B CFN99064 104700-96-1 1mg QQ客服：2056216494
    灵芝醇B CFN99064 104700-96-1 5mg QQ客服：2056216494
    灵芝醇B CFN99064 104700-96-1 10mg QQ客服：2056216494
    灵芝醇B CFN99064 104700-96-1 20mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • AMB Express2020. 10(1):126.
  • Int J Mol Sci.2017, 19(1)
  • Industrial Crops and Products2017, 95:286-295
  • Oncol Rep.2019, 41(4):2453-2463
  • Molecules.2020, 25(15):3353.
  • Nutraceuticals2022, 2(3),150-161
  • Braz J Biol.2023, 82:e266573.
  • J Nat Prod.2015, 78(6):1339-4
  • Histol Histopathol.2022, 18518.
  • Food Res Int.2018, 106:909-919
  • J-STAGE2015, 249-255
  • Food Res Int.2022, 157:111397.
  • Acta horticulturae2017, 1158:257-268
  • PLoS One.2018, 13(4):e0195642
  • J Biochem Mol Toxicol.2021, 35(5):e22731.
  • Mol Pharmacol.2021, 99(2):163-174.
  • Phytochemistry Letters2021, 43:80-87.
  • Phytother Res.2023, 37(10):4587-4606.
  • Comput Biol Chem.2019, 83:107096
  • Korean Journal of Pharmacognosy.2015, 46(4):352-364
  • Hum Exp Toxicol.2023, 42:9603271221145386.
  • Biochem Biophys Res Commun.2020, 530(1):4-9.
  • J Sci Food Agric.2023, 103(1):213-220.
  • ...
    • 生物活性
    Description: Ganoderol B is a potent α-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of α-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.
    Targets: Androgen Receptor
    In vitro:
    Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum
    Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum[Pubmed: 21596546]
    Abstract α-Glucosidase inhibitor has considerable potential as a diabetes mellitus type 2 drug because it prevents the digestion of carbohydrates. The search for the constituents reducing α-glucosidase activity led to the finding of active compounds in the fruiting body of Ganoderma lucidum. The CHCl(3) extract of the fruiting body of G. lucidum was found to show inhibitory activity on α-glucosidase in vitro. The neutral fraction, with an IC(50) of 88.7 μg/ml, had stronger inhibition than a positive control, acarbose, with an IC(50) of 336.7 μg/ml (521.5 μM). The neutral fraction was subjected to silica gel column chromatography and repeated p-HPLC to provide an active compound, (3β,24E)-lanosta-7,9(11),24-trien-3,26-diol (ganoderol B). It was found to have high α-glucosidase inhibition, with an IC(50) of 48.5 μg/ml (119.8 μM). Copyright © 2011 Elsevier GmbH. All rights reserved.
    In vivo:
    Bioorg Med Chem. 2007 Jul 15;15(14):4966-72. Epub 2007 Apr 25.
    The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum.[Pubmed: 17499997]
    Ganoderol B with 5alpha-reductase inhibitory activity and the ability to bind to androgen receptor (AR) can inhibit androgen-induced LNCaP cell growth and suppress regrowth of the ventral prostate induced by testosterone in rats. The down-regulation of AR signaling by ganoderol B provides an important mechanism for its anti-androgenic activity. In view of the fact that PSA (prostatic specific antigen, a well-accepted prognostic indicator of prostate cancer) is down-regulated, an important implication of this study is that ganoderol B intervention strategy aimed at toning down the amplitude of androgen signaling could be helpful in controlling morbidity of prostate cancer. In conclusion, our result suggests that ganoderol B might be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of androgen and its receptor.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2691 mL 11.3456 mL 22.6912 mL 45.3823 mL 56.7279 mL
    5 mM 0.4538 mL 2.2691 mL 4.5382 mL 9.0765 mL 11.3456 mL
    10 mM 0.2269 mL 1.1346 mL 2.2691 mL 4.5382 mL 5.6728 mL
    50 mM 0.0454 mL 0.2269 mL 0.4538 mL 0.9076 mL 1.1346 mL
    100 mM 0.0227 mL 0.1135 mL 0.2269 mL 0.4538 mL 0.5673 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝醇A; Ganoderol A CFN99065 104700-97-2 C30H46O2 = 438.7 5mg QQ客服：2056216494
    15,26-二羟基羊毛甾-7,9(11),24-三烯-3-酮; 15,26-Dihydroxylanosta-7,9(11),24-trien-3-one CFN95604 420781-85-7 C30H46O3 = 454.7 5mg QQ客服：2056216494
    灵芝醇F; Ganoderiol F CFN99244 114567-47-4 C30H46O3 = 454.7 5mg QQ客服：1457312923
    灵芝萜酮二醇 ; Ganodermanondiol CFN99085 107900-76-5 C30H48O3 = 456.7 5mg QQ客服：3257982914
    灵芝醇A; Ganoderiol A CFN80461 106518-61-0 C30H50O4 = 474.37 5mg QQ客服：3257982914
    灵芝马酮; Ganodermanontriol CFN99077 106518-63-2 C30H48O4 = 472.7 20mg QQ客服：215959384
    新化合物25; New compound 25 CFN95617 N/A C30H46O4 = 470.7 5mg QQ客服：1413575084
    Lucialdehyde A; Lucialdehyde A CFN90304 420781-84-6 C30H46O2 = 438.69 5mg QQ客服：1457312923
    灵芝醛A; Ganoderal A CFN90306 104700-98-3 C30H44O2 = 436.68 5mg QQ客服：2056216494
    灵芝酮A; Ganoderone A CFN90303 873061-79-1 C30H48O3 = 456.70 5mg QQ客服：3257982914

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