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  • 乙酰氧基异戊酰阿卡宁

    Acetoxyisovalerylalkannin

    乙酰氧基异戊酰阿卡宁
    产品编号 CFN92025
    CAS编号 69091-17-4
    分子式 = 分子量 C23H26O8 = 430.5
    产品纯度 >=98%
    物理属性 Red powder
    化合物类型 Quinones
    植物来源 The roots of Lithosperraum erythrorhizon Sieb. et Zucc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    乙酰氧基异戊酰阿卡宁 CFN92025 69091-17-4 10mg QQ客服:2159513211
    乙酰氧基异戊酰阿卡宁 CFN92025 69091-17-4 20mg QQ客服:2159513211
    乙酰氧基异戊酰阿卡宁 CFN92025 69091-17-4 50mg QQ客服:2159513211
    乙酰氧基异戊酰阿卡宁 CFN92025 69091-17-4 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Weizmann Institute of Science (Israel)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • University of the Basque Country (Spain)
  • Seoul National University (Korea)
  • University of Madras (India)
  • University of Wisconsin-Madison (USA)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
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  • Univerzita Karlova v Praze (Czech Republic)
  • Ain Shams University (Egypt)
  • National Research Council of Canada (Canada)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Chang Gung University (Taiwan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J. of Med. Plant Research.2013, 90-151
  • Int J Mol Med.2015, 35(5):1237-45
  • Acta Physiologiae Plantarum2015, 37:1736
  • J Pharm Biomed Anal2016, 118:183-194
  • J Pharm Anal.2016, 6(6):363-373
  • Food Analytical Methods2017, 10:3225–3234
  • BMC Complement Altern Med.2017, 17(1):393
  • Int J Anal Chem.2017, 2017:1254721
  • J Ethnopharmacol.2017, 209:305-316
  • Molecules.2017, 22(11)
  • Universidade Estadual Paulista2017, 42785
  • Front Pharmacol.2017, 8:205
  • Analytical Methods2018, 10(27)
  • Fitoterapia.2018, 124:92-102
  • Molecules.2018, 23(9):E2121
  • Wageningen University & Research2018, January 2018
  • J of Physics Conference Series2019, 1349(1)
  • BMC Complement Altern Med.2019, 19(1):339
  • BMC Complement Altern Med.2019, 19(1):367
  • Kor. J. Herbol.2019, 34(2):59-66
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Planta Med.2019, 85(4):347-355
  • Br J Pharmacol.2020, 10.1111
  • ...
  • 生物活性
    Description: Acetoxyisovalerylalkannin may have anti-ageing activity, it can upregulate Collagen-I, elastin and involucrin syntheses in human dermal fibroblasts or keratinocytes.
    In vitro:
    Natural Product Research, 2015, Mar 26,30(5):574-577.
    Anti-skin ageing activity of napthoquinones from Arnebia nobilis Reichb.f.[Pubmed: 25810219]
    The present isolation and identification of napthoquinones from roots of Arnebia nobilis Reichb.f. can lead to the discovery of new anti-skin ageing ingredient in colour cosmetics.
    METHODS AND RESULTS:
    Four compounds have been isolated and purified by rigorous column chromatography. The compounds are identified as β, β-dimethylacryl alkannin (AN-I), Acetoxyisovalerylalkannin (AAN-II), acetyl alkannin (AN-III) and alkannin (AN-IV) by interpretation of spectroscopic data. This study is the first to report the isolation of Acetoxyisovaleryl alkannin (AAN-II) from A. nobilis. The IC50 values of the compounds, determined in human skin cells (human dermal fibroblasts and human keratinocytes) and mouse embryonic fibroblasts (NIH3T3) varied significantly among the four alkannins. Among the four compounds, β-acetoxyisovaleryl alkannin (AAN-II) significantly inhibited hydrogen peroxide (H2O2)-induced red blood corpuscle haemolysis and cellular senescence in human dermal fibroblasts. Collagen-I, elastin and involucrin syntheses in human dermal fibroblasts or keratinocytes were up regulated by AAN-II.
    CONCLUSIONS:
    These results support the potential utility of alkannins as novel anti-ageing ingredients.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3229 mL 11.6144 mL 23.2288 mL 46.4576 mL 58.072 mL
    5 mM 0.4646 mL 2.3229 mL 4.6458 mL 9.2915 mL 11.6144 mL
    10 mM 0.2323 mL 1.1614 mL 2.3229 mL 4.6458 mL 5.8072 mL
    50 mM 0.0465 mL 0.2323 mL 0.4646 mL 0.9292 mL 1.1614 mL
    100 mM 0.0232 mL 0.1161 mL 0.2323 mL 0.4646 mL 0.5807 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    乙酰氧基异戊酰阿卡宁; Acetoxyisovalerylalkannin CFN92025 69091-17-4 C23H26O8 = 430.5 20mg QQ客服:3257982914
    黄钟花醌; Lapachol CFN97403 84-79-7 C15H14O3 = 242.3 20mg QQ客服:1148253675
    去氧紫草素; Deoxyshikonin CFN92024 43043-74-9 C16H16O4 = 272.3 20mg QQ客服:2159513211
    紫草素; Shikonine CFN92622 517-89-5 C16H16O5 = 288.3 20mg QQ客服:2159513211
    紫草素; Shikonin CFN99907 517-88-4 C16H16O5 = 288.31 20mg QQ客服:215959384
    乙酰紫草素; Acetylshikonin CFN90308 54984-93-9 C18H18O6 = 330.33 20mg QQ客服:2159513211
    异丁酰紫草; Isobutylshikonin CFN92023 52438-12-7 C20H22O6 = 358.4 10mg QQ客服:3257982914
    β,β-二甲基丙烯酰紫草素; Dimethylacrylshikonin CFN90164 24502-79-2 C21H22O6 = 370.39 20mg QQ客服:1148253675
    β,β-二甲基丙烯酰阿卡宁; Beta,beta-Dimethylacrylalkannin CFN90626 34539-65-6 C21H22O6 = 370.4 20mg QQ客服:1413575084
    异戊酰紫草素; Isovalerylshikonin CFN95222 52387-14-1 C21H24O6 = 372.4 10mg QQ客服:2932563308

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