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  • 异落叶松脂素

    Isolariciresinol

    异落叶松脂素
    产品编号 CFN98915
    CAS编号 548-29-8
    分子式 = 分子量 C20H24O6 = 360.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The herbs of Phyllanthus niruri
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异落叶松脂素 CFN98915 548-29-8 1mg QQ客服:1148253675
    异落叶松脂素 CFN98915 548-29-8 5mg QQ客服:1148253675
    异落叶松脂素 CFN98915 548-29-8 10mg QQ客服:1148253675
    异落叶松脂素 CFN98915 548-29-8 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Virginia (USA)
  • Semmelweis Unicersity (Hungary)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
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  • Lund University (Sweden)
  • Universit?t Basel (Switzerland)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antioxidants (Basel).2020, 9(11):1121.
  • Food Quality and Safety2018, 2:213-219
  • Mol Neurobiol.2022, 02873-9.
  • Toxicol Appl Pharmacol.2022, 434:115815.
  • Toxicol Res.2019, 35(4):371-387
  • J Mol Recognit.2020, 33(2):e2819
  • Int Immunopharmacol.2021, 101(Pt A):108181.
  • J Adv Res.2021, 35:245-257.
  • Evid Based Complement Alternat Med.2022, 2022:3483511
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
  • Biochem Biophys Res Commun.2018, 505(1):261-266
  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • Wageningen University & Research2018, January 2018
  • Biochemistry.2018, 57(40):5886-5896
  • Int J Biol Macromol.2019, 126:653-661
  • Evid Based Complement Alternat Med.2020, 2020:9416962.
  • Korean J. of Horticultural Sci. & Tech. 2017, 793-804
  • J Biosci.2020, 45:46.
  • Int J Mol Sci.2019, 20(3):E651
  • Front Plant Sci.2021, 12:673337.
  • Biochem Pharmacol. 2020, 177:114014.
  • Int J Biol Macromol.2020, 169:342-351
  • Nat Prod Commun.2017, 12(5):771-778
  • ...
  • 生物活性
    Description: Isolariciresinol has antioxidant and anti-inflammatory activities during an in vitro gastro-intestinal digestion of the Radix Isatidis extract (RIE).
    Targets: Immunology & Inflammation related
    In vitro:
    J Ethnopharmacol. 2014 Nov 18;157:55-61.
    In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion.[Pubmed: 25256688]
    Radix Isatidis called "Ban-Lan-Gen" is one of the most commonly-used traditional Chinese medicines for antiviral, anti-inflammatory, antioxidant and antipyretic purposes. Investigate the bioaccessibility of uridine, epigoitrin, adenosine, clemastanin B, indigoticoside A and isolariciresinol as well as the antioxidant and anti-inflammatory activities during an in vitro gastro-intestinal digestion of the Radix Isatidis extract (RIE).
    METHODS AND RESULTS:
    High performance liquid chromatography (HPLC) technique was adopted to determine the bioaccessibility of six bioactive compounds in RIE. Antioxidant activities of RIE in different digestive stages were determined by 1,1-Diphenyl-2-picrylhydrazyl (DPPH), superoxide anion and hydroxyl radical scavenging abilities. Anti-inflammatory activity was assayed by the inhibitions of inflammatory cytokines such as nitrous oxide (NO), prostaglandin E2 (PGE2) and tumor necrosis factor α(TNF-α) producted by lipopolysaccharide (LPS) stimulated RAW264.7 cells. The bioaccessibility of uridine, epigoitrin, adenosine, clemastanin B, indigoticoside A and isolariciresinol were 15.38%, 18.28%, 24.01%, 6.50%, 8.65% and 17.78%, respectively. Also, the digestion products still possessed certain antioxidant activities. The antioxidant activity was highly correlated with lignans (clemastanin B, indigoticoside A and isolariciresino). The anti-inflammation activity of the three samples decreased in the order: IN sample (the solution that had diffused into the dialysis tubing)>Nondigested sample (RIE solution)>Gastric sample (post-gastric digestion)>OUT sample (material that remained in the gastro-intestinal tract).
    CONCLUSIONS:
    Results obtained in this research reveal the amount of bioactive compounds from RIE that could be available for absorption in vivo. The antioxidant activity decreased significantly but the anti-inflammatory activity was enhanced in serum-available fraction after gastro-intestinal digestion in vitro. This study could provide a scientific basis for a deeper pharmacological activity study of Radix Isatidis and a simple method for pharmacodynamic material basis research.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7747 mL 13.8735 mL 27.7469 mL 55.4939 mL 69.3674 mL
    5 mM 0.5549 mL 2.7747 mL 5.5494 mL 11.0988 mL 13.8735 mL
    10 mM 0.2775 mL 1.3873 mL 2.7747 mL 5.5494 mL 6.9367 mL
    50 mM 0.0555 mL 0.2775 mL 0.5549 mL 1.1099 mL 1.3873 mL
    100 mM 0.0277 mL 0.1387 mL 0.2775 mL 0.5549 mL 0.6937 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Nudiposide; Nudiposide CFN89146 62058-46-2 C27H36O12 = 552.57 5mg QQ客服:2159513211
    异紫杉脂素9,9'-缩丙酮; Isotaxiresinol 9,9'-acetonide CFN97774 252333-72-5 C22H26O6 = 386.44 5mg QQ客服:215959384
    异橄榄树脂素; Cycloolivil CFN96185 3064-05-9 C20H24O7 = 376.4 5mg QQ客服:2159513211
    异落叶松脂素; Isolariciresinol CFN98915 548-29-8 C20H24O6 = 360.4 5mg QQ客服:1148253675
    9,9'-O-Isopropyllidene-isolariciresinol; 9,9'-O-Isopropyllidene-isolariciresinol CFN98276 252333-71-4 C23H28O6 = 400.5 5mg QQ客服:1413575084
    异落叶松脂素 9'-beta-D-吡喃木糖苷; Schizandriside CFN96693 71222-06-5 C25H32O10 = 492.52 5mg QQ客服:2932563308
    (-)-异落叶松脂素-9'-O-beta-D-吡喃葡萄糖苷; (-)-Isolariciresinol 9'-O-glucoside CFN89431 143236-04-8 C26H34O11 = 522.54 5mg QQ客服:3257982914
    Vitexdoin A; Vitexdoin A CFN96194 1186021-77-1 C19H18O6 = 342.4 5mg QQ客服:3257982914
    7,8,9,9-四脱氢异落叶松树脂酚; 7,8,9,9-Tetradehydroisolariciresinol CFN99605 145918-59-8 C20H20O6 = 356.4 5mg QQ客服:1413575084
    Vitedoin A; Vitedoin A CFN96448 819861-40-0 C20H20O6 = 356.37 5mg QQ客服:1148253675

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