南烛木糖甙

Lyoniside

	产品编号	CFN98451
	CAS编号	34425-25-7
	分子式 = 分子量	C₂₇H₃₆O₁₂ = 552.6
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Lignans
	植物来源	The stem barks of Canarium bengalense
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产品名称	产品编号	CAS编号	包装	QQ客服
南烛木糖甙	CFN98451	34425-25-7	1mg	QQ客服：1457312923
南烛木糖甙	CFN98451	34425-25-7	5mg	QQ客服：1457312923
南烛木糖甙	CFN98451	34425-25-7	10mg	QQ客服：1457312923
南烛木糖甙	CFN98451	34425-25-7	20mg	QQ客服：1457312923

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Description:

Lyoniside and saracoside are cytotoxic to promastigotes and intracellular amastigotes, they demonstrate strong anti-leishmanial efficacies in BALB/c mice model of leishmaniasis, suggests that these two compounds potential anti-leishmanial candidates. The synergistic action of lyoniside and triterpene acids was demonstrated in inhibitory effect exerted on germination and growth of Pinus sylvestris.

Targets:

Antifection

In vitro:

Phytochem. Lett., 2011, 4(2):138-43.

Isolation and biological activities of lyoniside from rhizomes and stems of Vaccinium myrtillus.[Reference: WebLink]

A lignan glycoside identified as Lyoniside (9-O-β-d-xylopyranosyl(+)lyoniresinol) was obtained from ethanol extracts of the rhizomes and stems of bilberry (Vaccinium myrtillus L.), on a preparative scale, by droplet counter-current chromatography. The application of this method permitted the isolation of a pure substance in only one chromatographical step.
METHODS AND RESULTS:
The occurrence of Lyoniside in bilberry is reported for the first time. Seasonal fluctuations in the content of this compound in plant organs were demonstrated showing its highest levels in bilberry rhizomes and stems during the winter and their subsequent decrease in the spring. In vitro, the purified Lyoniside was evaluated for antioxidant, allelopathic and antifungal activities. It showed significant radical scavenging properties in a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay with IC50 of 23 μg ml−1. Applied at concentration of 10 μg ml−1, it suppressed by 75% the seedling radical growth of Lactuca sativa and Lepidium sativum, and exerted strong inhibitory effect (55%) on germination of Larix decidua. Moreover, the synergistic action of Lyoniside and triterpene acids was demonstrated in inhibitory effect exerted on germination and growth of Pinus sylvestris.
CONCLUSIONS:
Among 5 tested fungi strains of Ascomycota, the highest susceptibility was shown by Fusarium oxysporum and Mucor hiemalis, with mycelial growth inhibited by Lyoniside concentration of 50 μg ml−1 by 78 and 80%, respectively.

In vivo:

Biochem Pharmacol. 2013 Dec 15;86(12):1673-87.

The lignan glycosides lyoniside and saracoside poison the unusual type IB topoisomerase of Leishmania donovani and kill the parasite both in vitro and in vivo.[Pubmed: 24134912]

Lignans are diphenyl propanoids with vast range of biological activities. The present study provides an important insight into the anti-leishmanial activities of two lignan glycosides, viz. Lyoniside and saracoside.
METHODS AND RESULTS:
These compounds inhibit catalytic activities of topoisomerase IB (LdTopIB) of Leishmania donovani in non-competitive manner and stabilize the LdTopIB mediated cleavage complex formation both in vitro and in Leishmania promastigotes and subsequently inhibit the religation of cleaved strand. These two compounds not only poison LdTopIB but also can interact with the free enzyme LdTopIB. We have also shown that Lyoniside and saracoside are cytotoxic to promastigotes and intracellular amastigotes. The protein-DNA complex formation leads to double strand breaks in DNA which ultimately triggers apoptosis-like cell death in the parasite. Along with their cytotoxicity towards sodium antimony gluconate (SAG) sensitive AG83 strain, their ability to kill SAG resistant GE1 strain makes these two compounds potential anti-leishmanial candidates. Not only they effectively kill L. donovani amastigotes inside macrophages in vitro, Lyoniside and saracoside demonstrated strong anti-leishmanial efficacies in BALB/c mice model of leishmaniasis. Treatment with these lignan glycosides produce nitric oxide and reactive oxygen species which result in almost complete clearance of the liver and splenic parasite burden. These compounds do not inhibit human topoisomerase IB upto 200μM concentrations and had poor cytotoxic effect on uninfected cultured murine peritoneal macrophages upto 100μM concentrations.
CONCLUSIONS:
Taken together it can be concluded that these compounds can be developed into excellent therapeutic agent against deadly disease leishmaniasis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
(-)-5'-甲氧基异落叶松脂素-9'-O-beta-D-吡喃葡萄糖苷; (-)-5'-Methoxyisolariciresinol 3alpha-O-beta-glucopyranoside	CFN95403	143236-03-7	C₂₇H₃₆O₁₂ = 552.6	5mg	QQ客服：2056216494
(+)-南烛木树脂酚; (+)-Lyoniresinol	CFN99488	14464-90-5	C₂₂H₂₈O₈ = 420.5	5mg	QQ客服：2159513211
南烛木糖甙; Lyoniside	CFN98451	34425-25-7	C₂₇H₃₆O₁₂ = 552.6	5mg	QQ客服：1413575084
(+)-南烛木树脂酚9'-O-葡萄糖甙; (+)-Lyoniresinol 9'-O-glucoside	CFN97964	87585-32-8	C₂₈H₃₈O₁₃ = 582.6	10mg	QQ客服：2159513211
(-)-Lyoniresinol 9'-O-glucoside ; (-)-Lyoniresinol 9'-O-glucoside	CFN96732	143236-02-6	C₂₈H₃₈O₁₃ = 582.59	5mg	QQ客服：2056216494
Nudiposide; Nudiposide	CFN89146	62058-46-2	C₂₇H₃₆O₁₂ = 552.57	5mg	QQ客服：2056216494
异紫杉脂素9,9'-缩丙酮; Isotaxiresinol 9,9'-acetonide	CFN97774	252333-72-5	C₂₂H₂₆O₆ = 386.44	5mg	QQ客服：1413575084
异橄榄树脂素; Cycloolivil	CFN96185	3064-05-9	C₂₀H₂₄O₇ = 376.4	5mg	QQ客服：2056216494
异落叶松脂素; Isolariciresinol	CFN98915	548-29-8	C₂₀H₂₄O₆ = 360.4	5mg	QQ客服：215959384
9,9'-O-Isopropyllidene-isolariciresinol; 9,9'-O-Isopropyllidene-isolariciresinol	CFN98276	252333-71-4	C₂₃H₂₈O₆ = 400.5	5mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8096 mL	9.0481 mL	18.0963 mL	36.1925 mL	45.2407 mL
5 mM	0.3619 mL	1.8096 mL	3.6193 mL	7.2385 mL	9.0481 mL
10 mM	0.181 mL	0.9048 mL	1.8096 mL	3.6193 mL	4.5241 mL
50 mM	0.0362 mL	0.181 mL	0.3619 mL	0.7239 mL	0.9048 mL
100 mM	0.0181 mL	0.0905 mL	0.181 mL	0.3619 mL	0.4524 mL

南烛木糖甙

Lyoniside

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