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  • 南烛木糖甙


    产品编号 CFN98451
    CAS编号 34425-25-7
    分子式 = 分子量 C27H36O12 = 552.6
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The stem barks of Canarium bengalense
    产品名称 产品编号 CAS编号 包装 QQ客服
    南烛木糖甙 CFN98451 34425-25-7 1mg QQ客服:1457312923
    南烛木糖甙 CFN98451 34425-25-7 5mg QQ客服:1457312923
    南烛木糖甙 CFN98451 34425-25-7 10mg QQ客服:1457312923
    南烛木糖甙 CFN98451 34425-25-7 20mg QQ客服:1457312923
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • National Research Council of Canada (Canada)
  • Shanghai Institute of Organic Chemistry (China)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Chinese University of Hong Kong (China)
  • University of Bordeaux (France)
  • University of Bonn (Germany)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Universidade Federal de Santa Catarina (Brazil)
  • University of the Basque Country (Spain)
  • Medical University of South Carolina (USA)
  • University of Minnesota (USA)
  • Universidad de Antioquia (Colombia)
  • University of Canterbury (New Zealand)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
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  • ...
  • 生物活性
    Description: Lyoniside and saracoside are cytotoxic to promastigotes and intracellular amastigotes, they demonstrate strong anti-leishmanial efficacies in BALB/c mice model of leishmaniasis, suggests that these two compounds potential anti-leishmanial candidates. The synergistic action of lyoniside and triterpene acids was demonstrated in inhibitory effect exerted on germination and growth of Pinus sylvestris.
    Targets: Antifection
    In vitro:
    Phytochem. Lett., 2011, 4(2):138-43.
    Isolation and biological activities of lyoniside from rhizomes and stems of Vaccinium myrtillus.[Reference: WebLink]
    A lignan glycoside identified as Lyoniside (9-O-β-d-xylopyranosyl(+)lyoniresinol) was obtained from ethanol extracts of the rhizomes and stems of bilberry (Vaccinium myrtillus L.), on a preparative scale, by droplet counter-current chromatography. The application of this method permitted the isolation of a pure substance in only one chromatographical step.
    The occurrence of Lyoniside in bilberry is reported for the first time. Seasonal fluctuations in the content of this compound in plant organs were demonstrated showing its highest levels in bilberry rhizomes and stems during the winter and their subsequent decrease in the spring. In vitro, the purified Lyoniside was evaluated for antioxidant, allelopathic and antifungal activities. It showed significant radical scavenging properties in a 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay with IC50 of 23 μg ml−1. Applied at concentration of 10 μg ml−1, it suppressed by 75% the seedling radical growth of Lactuca sativa and Lepidium sativum, and exerted strong inhibitory effect (55%) on germination of Larix decidua. Moreover, the synergistic action of Lyoniside and triterpene acids was demonstrated in inhibitory effect exerted on germination and growth of Pinus sylvestris.
    Among 5 tested fungi strains of Ascomycota, the highest susceptibility was shown by Fusarium oxysporum and Mucor hiemalis, with mycelial growth inhibited by Lyoniside concentration of 50 μg ml−1 by 78 and 80%, respectively.
    In vivo:
    Biochem Pharmacol. 2013 Dec 15;86(12):1673-87.
    The lignan glycosides lyoniside and saracoside poison the unusual type IB topoisomerase of Leishmania donovani and kill the parasite both in vitro and in vivo.[Pubmed: 24134912]
    Lignans are diphenyl propanoids with vast range of biological activities. The present study provides an important insight into the anti-leishmanial activities of two lignan glycosides, viz. Lyoniside and saracoside.
    These compounds inhibit catalytic activities of topoisomerase IB (LdTopIB) of Leishmania donovani in non-competitive manner and stabilize the LdTopIB mediated cleavage complex formation both in vitro and in Leishmania promastigotes and subsequently inhibit the religation of cleaved strand. These two compounds not only poison LdTopIB but also can interact with the free enzyme LdTopIB. We have also shown that Lyoniside and saracoside are cytotoxic to promastigotes and intracellular amastigotes. The protein-DNA complex formation leads to double strand breaks in DNA which ultimately triggers apoptosis-like cell death in the parasite. Along with their cytotoxicity towards sodium antimony gluconate (SAG) sensitive AG83 strain, their ability to kill SAG resistant GE1 strain makes these two compounds potential anti-leishmanial candidates. Not only they effectively kill L. donovani amastigotes inside macrophages in vitro, Lyoniside and saracoside demonstrated strong anti-leishmanial efficacies in BALB/c mice model of leishmaniasis. Treatment with these lignan glycosides produce nitric oxide and reactive oxygen species which result in almost complete clearance of the liver and splenic parasite burden. These compounds do not inhibit human topoisomerase IB upto 200μM concentrations and had poor cytotoxic effect on uninfected cultured murine peritoneal macrophages upto 100μM concentrations.
    Taken together it can be concluded that these compounds can be developed into excellent therapeutic agent against deadly disease leishmaniasis.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8096 mL 9.0481 mL 18.0963 mL 36.1925 mL 45.2407 mL
    5 mM 0.3619 mL 1.8096 mL 3.6193 mL 7.2385 mL 9.0481 mL
    10 mM 0.181 mL 0.9048 mL 1.8096 mL 3.6193 mL 4.5241 mL
    50 mM 0.0362 mL 0.181 mL 0.3619 mL 0.7239 mL 0.9048 mL
    100 mM 0.0181 mL 0.0905 mL 0.181 mL 0.3619 mL 0.4524 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (-)-异落叶松脂素-9'-O-beta-D-吡喃葡萄糖苷; (-)-Isolariciresinol 9'-O-glucoside CFN89431 143236-04-8 C26H34O11 = 522.54 5mg QQ客服:2056216494
    Vitexdoin A; Vitexdoin A CFN96194 1186021-77-1 C19H18O6 = 342.4 5mg QQ客服:2159513211
    7,8,9,9-四脱氢异落叶松树脂酚; 7,8,9,9-Tetradehydroisolariciresinol CFN99605 145918-59-8 C20H20O6 = 356.4 5mg QQ客服:1413575084
    Vitedoin A; Vitedoin A CFN96448 819861-40-0 C20H20O6 = 356.37 5mg QQ客服:1413575084
    (-)-5'-甲氧基异落叶松脂素-9'-O-beta-D-吡喃葡萄糖苷; (-)-5'-Methoxyisolariciresinol 3alpha-O-beta-glucopyranoside CFN95403 143236-03-7 C27H36O12 = 552.6 5mg QQ客服:215959384
    (+)-南烛木树脂酚; (+)-Lyoniresinol CFN99488 14464-90-5 C22H28O8 = 420.5 5mg QQ客服:1457312923
    南烛木糖甙; Lyoniside CFN98451 34425-25-7 C27H36O12 = 552.6 5mg QQ客服:3257982914
    (+)-南烛木树脂酚9'-O-葡萄糖甙; (+)-Lyoniresinol 9'-O-glucoside CFN97964 87585-32-8 C28H38O13 = 582.6 10mg QQ客服:2056216494
    (-)-Lyoniresinol 9'-O-glucoside ; (-)-Lyoniresinol 9'-O-glucoside CFN96732 143236-02-6 C28H38O13 = 582.59 5mg QQ客服:3257982914
    Nudiposide; Nudiposide CFN89146 62058-46-2 C27H36O12 = 552.57 5mg QQ客服:2056216494





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