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  • 反式石竹烯


    产品编号 CFN90502
    CAS编号 87-44-5
    分子式 = 分子量 C15H24 = 204.36
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Sesquiterpenoids
    植物来源 The seeds of Alpinia katsumadai Hayata.
    产品名称 产品编号 CAS编号 包装 QQ客服
    反式石竹烯 CFN90502 87-44-5 10mg QQ客服:1413575084
    反式石竹烯 CFN90502 87-44-5 20mg QQ客服:1413575084
    反式石竹烯 CFN90502 87-44-5 50mg QQ客服:1413575084
    反式石竹烯 CFN90502 87-44-5 100mg QQ客服:1413575084
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  • 生物活性
    Description: trans-Caryophyllene, a PPAR-α agonist, which has neuroprotective effects in various neurological disorders, such as chemical induced seizure and brain damage. trans-Caryophyllene suppresses the hypoxia-induced neuroinflammatory response through inhibition of NF-κB activation in microglia.trans-Caryophyllene also reduces both acute and chronic pain in mice, which may be mediated through the opioid and endocannabinoid systems.
    Targets: PPAR | IL Receptor | TNF-α | SOD | ROS | NF-kB
    In vitro:
    Biochem Biophys Res Commun. 2014 Feb 21;444(4):451-4.
    A role for trans-caryophyllene in the moderation of insulin secretion.[Pubmed: 24486541]
    Glucose-stimulated insulin secretion (GSIS) is essential for the control of metabolic fuel homeostasis and its impairment is a key element in the failure of β-cells in type 2 diabetes.
    Trans-caryophyllene (TC), an important constituent of the essential oil of several species of plants, has been reported to activate the type 2 cannabinoid receptor (CB2R). The effects of TC on GSIS are still unknown. Our results demonstrate that administration of TC in MIN6 cells promotes GSIS in a dose dependent manner. However, inhibition of CB2R by a specific inhibitor or specific RNA interference abolished the effects of TC on GSIS, which suggests that the effects of TC on GSIS are dependent on activation of CB2R. Further study demonstrated that treatment with TC leads to the activation of small G protein Arf6 as well as Rac1 and Cdc42. Importantly, Arf6 silencing abolished the effects of TC on GSIS, which suggests that Arf6 participates in mediating the effects of TC on GSIS.
    We conclude from these data that TC has a novel role in regulating GSIS in pancreatic β-cells.
    J Mol Neurosci. 2014 Sep;54(1):41-8.
    Trans-caryophyllene suppresses hypoxia-induced neuroinflammatory responses by inhibiting NF-κB activation in microglia.[Pubmed: 24488604]
    trans-Caryophyllene (TC), may have protective effects against hypoxia-induced neuroinflammatory responses.
    In this study, trans-Caryophyllene was found to significantly inhibit hypoxia-induced cytotoxicity as well as the release of proinflammatory cytokines, including IL-1β, TNF-α, and IL-6, through activation of BV2 microglia following hypoxic exposure (1 % O2, 24 h). Furthermore, trans-Caryophyllene significantly inhibited hypoxia-induced generation of reactive oxygen species (ROS) in mitochondria as well as the activation of nuclear factor kappa B (NF-κB) in microglia. Importantly, trans-Caryophyllene 's effects on inhibiting the activation of NF-κB and the secretion of inflammatory cytokines can be abolished by muting the CB2R using small RNA interference.
    These observations indicate that trans-Caryophyllene suppresses the hypoxia-induced neuroinflammatory response through inhibition of NF-κB activation in microglia. Therefore, trans-Caryophyllene may be beneficial in preventing hypoxia-induced neuroinflammation.
    In vivo:
    Neurochem Res. 2015 Jan;40(1):118-23.
    Neuroprotective effects of trans-caryophyllene against kainic acid induced seizure activity and oxidative stress in mice.[Pubmed: 25417010]
    Trans-caryophyllene (TC), a component of essential oil found in many flowering plants, has shown its neuroprotective effects in various neurological disorders. However, the effects of TC on epilepsy haven't been reported before.
    In this study, we investigated the effect of TC on kainic acid-induced seizure activity caused by oxidative stress and pro-inflammation. We found that TC pretreatment significantly decreased seizure activity score compared to kainic acid treated group. Importantly, TC pretreatment leads to lowering the mortality in kainic acid treated mice. In addition, TC was found to significantly inhibit KA-induced generation of malondialdehyde. TC pretreatment also preserved the activity of GPx, SOD, and CAT. Notably, our data shows that an important property of TC is its capacity to exert cerebral anti-inflammatory effects by mitigating the expression of proinflammatory cytokines, such as TNF-α and IL-1β.
    These data suggest that TC has a potential protective effect on chemical induced seizure and brain damage.
    Epilepsy Behav . 2016 Mar;56:26-31.
    Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures[Pubmed: 26827298]
    Abstract Increasing evidence suggests that plant-derived extracts and their isolated components are useful for treatment of seizures and, hence, constitute a valuable source of new antiepileptic drugs with improved efficacy and better adverse effect profile. β-Caryophyllene is a natural bicyclic sesquiterpene that occurs in a wide range of plant species and displays a number of biological actions, including neuroprotective activity. In the present study, we tested the hypothesis that β-caryophyllene displays anticonvulsant effects. In addition, we investigated the effect of β-caryophyllene on behavioral parameters and on seizure-induced oxidative stress. Adult C57BL/6 mice received increasing doses of β-caryophyllene (0, 10, 30, or 100mg/kg). After 60 min, we measured the latencies to myoclonic and generalized seizures induced by pentylenetetrazole (PTZ, 60 mg/kg). We found that β-caryophyllene increased the latency to myoclonic jerks induced by PTZ. This result was confirmed by electroencephalographic analysis. In a separate set of experiments, we found that mice treated with an anticonvulsant dose of β-caryophyllene (100mg/kg) displayed an improved recognition index in the object recognition test. This effect was not accompanied by behavioral changes in the open-field, rotarod, or forced swim tests. Administration of an anticonvulsant dose of β-caryophyllene (100mg/kg) did not prevent PTZ-induced oxidative stress (i.e., increase in the levels of thiobarbituric acid-reactive substances or the decrease in nonprotein thiols content). Altogether, the present data suggest that β-caryophyllene displays anticonvulsant activity against seizures induced by PTZ in mice. Since no adverse effects were observed in the same dose range of the anticonvulsant effect, β-caryophyllene should be further evaluated in future development of new anticonvulsant drugs. Keywords: Cannabinoids; Convulsion; EEG; Natural product; PTZ; Phytomedicine.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.8933 mL 24.4666 mL 48.9333 mL 97.8665 mL 122.3331 mL
    5 mM 0.9787 mL 4.8933 mL 9.7867 mL 19.5733 mL 24.4666 mL
    10 mM 0.4893 mL 2.4467 mL 4.8933 mL 9.7867 mL 12.2333 mL
    50 mM 0.0979 mL 0.4893 mL 0.9787 mL 1.9573 mL 2.4467 mL
    100 mM 0.0489 mL 0.2447 mL 0.4893 mL 0.9787 mL 1.2233 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    反式石竹烯; trans-Caryophyllene CFN90502 87-44-5 C15H24 = 204.36 20mg QQ客服:3257982914
    石竹素; Caryophyllene oxide CFN99239 1139-30-6 C15H24O = 220.4 20mg QQ客服:2159513211
    可布酮; Kobusone CFN98253 24173-71-5 C14H22O2 = 222.3 5mg QQ客服:1413575084
    α-石竹烯; Alpha-caryophyllene CFN93582 6753-98-6 C15H24 = 204.4 20mg QQ客服:215959384
    花姜酮; Zerumbone CFN91066 471-05-6 C15H22O = 218.3 20mg QQ客服:3257982914
    环氧化蛇麻烯II; Humulene epoxide II CFN98008 19888-34-7 C15H24O = 220.4 5mg QQ客服:2159513211
    十氢-7,7,9a-三甲基-4-亚甲基-6H-环氧乙烯并[5,6]环壬烷并[1,2-b]呋喃-6-酮; Epoxyparvinolide CFN99039 102227-61-2 C15H22O3 = 250.3 5mg QQ客服:1413575084
    大牛儿烯 D; Germacrene D CFN93281 37839-63-7 C15H24 = 204.4 5mg QQ客服:215959384
    环十五烷酮; Cyclopentadecanone CFN93169 502-72-7 C15H28O = 224.4 20mg QQ客服:1413575084
    麝香酮; Muscone CFN99518 541-91-3 C16H30O = 238.42 20mg QQ客服:215959384





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