花姜酮
Zerumbone
|
产品编号 |
CFN91066 |
CAS编号 |
471-05-6 |
分子式 = 分子量 |
C15H22O = 218.3 |
产品纯度 |
>=98% |
物理属性 |
Oil |
化合物类型 |
Sesquiterpenoids |
植物来源 |
The herbs of Zingiber officinale |
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
花姜酮 |
CFN91066 |
471-05-6 |
10mg |
QQ客服:1413575084 |
花姜酮 |
CFN91066 |
471-05-6 |
20mg |
QQ客服:1413575084 |
花姜酮 |
CFN91066 |
471-05-6 |
50mg |
QQ客服:1413575084 |
花姜酮 |
CFN91066 |
471-05-6 |
100mg |
QQ客服:1413575084 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
University of Stirling (United Kingdom)
Univerzita Karlova v Praze (Czech Republic)
Universiti Putra Malaysia(UPM) (Malaysia)
National Hellenic Research Foundation (Greece)
University of Malaya (Malaysia)
Macau University of Science and Technology (China)
Chulalongkorn University (Thailand)
Istanbul University (Turkey)
Shanghai University of TCM (China)
Monash University Sunway Campus (Malaysia)
Universidade Federal de Santa Catarina (Brazil)
Mendel University in Brno (Czech Republic)
National Research Council of Canada (Canada)
University of Hawaii Cancer Center (USA)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Description: |
Zerumbone is a potential antimicrobial and antibiofilm agent indicated for the therapeutic management of nosocomial medical device-related infections induced by dual-species biofilms of C. albicans and S. aureus. Zerumbone protects the neuronal injury and ameliorates the cognitive function by stimulating the proliferation of endogenous neural stem cells; it suppresses enterotoxigenic bacteroides fragilis infection-induced colonic inflammation through inhibition of NF-κΒ. Zerumbone exhibits a hepatoprotective effect against ALI through its antioxidant and anti-inflammatory activities and the possible mechanism might be mediated by the TLR4/NF-κB/COX-2 pathway. Zerumbone can be a potential candidate for development of immunosuppressive agent. |
Targets: |
NF-κB | TLR4 | COX | Notch-1 | Hes-1 | NOS | TNF-α | TLR |
In vitro: |
Microb Pathog. 2019 Oct 1;137:103768. | Efficacy of zerumbone against dual-species biofilms of Candida albicans and Staphylococcus aureus.[Pubmed: 31585154 ] | Candida albicans and Staphylococcus aureus are the most common opportunistic pathogens that co-exist as mixed biofilms. Dual-species biofilms of C. albicans and S. aureus cause nosocomial medical device-related infections that are strongly resistant to antibiotics and host immune responses compared with mono-species biofilms. The purpose of this study was to describe the efficacy of zerumbone derived from Zingiber zerumbet (L.) Smith, on dual-species biofilm formation. METHODS AND RESULTS: This study examined the inhibitory effects of zerumbone on planktonic cell growth, adhesion and biofilm formation. The results demonstrated that zerumbone remarkably inhibited mono- and dual-species biofilms formed by C. albicans and S. aureus using the XTT [2,3-bis(2-smethoxy-4-nitro-5-sulfo-phenyl)-2H-tetrazolium-5-carboxanilide]-reduction assay. Furthermore, a significant decrease in biomass and cell density of dual-species biofilms following zerumbone treatment was confirmed using confocal laser scanning microscopy (CLSM). CONCLUSIONS:
Therefore, our study suggests that zerumbone is a potential antimicrobial and antibiofilm agent indicated for the therapeutic management of nosocomial medical device-related infections induced by dual-species biofilms of C. albicans and S. aureus. |
|
In vivo: |
Folia Neuropathol. 2019;57(3):277-284. | Zerumbone promotes proliferation of endogenous neural stem cells in vascular dementia by regulating Notch signalling.[Pubmed: 31588714 ] | Present investigation determines the effect of zerumbone on the proliferation of stem cells in vascular dementia (VD) rats.
METHODS AND RESULTS:
Vascular dementia was induced by cerebral ischemia and reperfusion through non-invasive clamp. Rats were treated with zerumbone 50 mg/kg and 100 mg/kg intraperitoneally 30 min for four weeks after the surgery. Cognitive functions are determined by the Morris water maze (MWM) test and neurological function score in VD rats. Moreover mediators of inflammation and parameters of oxidative stress were estimated in the brain tissue homogenate of ischemia-induced vascular dementia rats. The expression of proteins and mRNA expressions were determined by western blot assay and RT-PCR methods. Moreover histopathological changes were observed by H&E staining on the brain tissue of vascular dementia rats.
There was a significant reduction in the cognitive function and neurological score in the zerumbone-treated group compared to the VD group of rats. Data of the study reveal that treatment with zerumbone attenuates the altered level of cytokines and markers of oxidative stress parameters in the brain tissue of VD rats. The expression of NICD, Hes-1 and Nestin proteins was significantly (p < 0.01) reduced in the brain tissue of the zerumbone-treated group compared to the VD group of rats. There was a significant reduction in the mRNA expression of Notch-1 and Hes-1 in the brain tissue of the zerumbone-treated group compared to the VD group of rats.
CONCLUSIONS:
This study concludes that treatment with zerumbone protects the neuronal injury and ameliorates the cognitive function by stimulating the proliferation of endogenous neural stem cells. Moreover proliferation of neural stem cells was stimulated in zerumbone-treated rats by regulating the Notch signalling. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
4.5809 mL |
22.9043 mL |
45.8085 mL |
91.617 mL |
114.5213 mL |
5 mM |
0.9162 mL |
4.5809 mL |
9.1617 mL |
18.3234 mL |
22.9043 mL |
10 mM |
0.4581 mL |
2.2904 mL |
4.5809 mL |
9.1617 mL |
11.4521 mL |
50 mM |
0.0916 mL |
0.4581 mL |
0.9162 mL |
1.8323 mL |
2.2904 mL |
100 mM |
0.0458 mL |
0.229 mL |
0.4581 mL |
0.9162 mL |
1.1452 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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