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  • α-石竹烯

    Alpha-caryophyllene

    α-石竹烯
    产品编号 CFN93582
    CAS编号 6753-98-6
    分子式 = 分子量 C15H24 = 204.4
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Humulus lupulus.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    α-石竹烯 CFN93582 6753-98-6 10mg QQ客服:215959384
    α-石竹烯 CFN93582 6753-98-6 20mg QQ客服:215959384
    α-石竹烯 CFN93582 6753-98-6 50mg QQ客服:215959384
    α-石竹烯 CFN93582 6753-98-6 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of East Anglia (United Kingdom)
  • Complutense University of Madrid (Spain)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Hamdard University (India)
  • Washington State University (USA)
  • Korea Institute of Oriental Medicine (Korea)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
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  • University of Virginia (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2019, 19(1):325
  • Evid Based Complement Alternat Med.2016, 2016:1739760
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • J Korean Soc Food Sci Nutr2020, doi: 10.3746.
  • Sci Rep.2015, 5:13194
  • Mol Immunol. 2016, 78:121-132
  • Nutrients.2018, 11(1):E17
  • Molecules.2019, 24(17):E3127
  • J Food Sci Technol.2019, 56(5):2712-2720
  • J. Food Composition and Anal.2022, V 109:104482.
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • Front Cell Dev Biol.2021, 9:764263.
  • Nutrients2020, 12(3):811.
  • PLoS One.2021, 16(9):e0257243.
  • J Agric Food Chem.2021, 69(46):14037-14047.
  • SBRAS2016, 12
  • Org Biomol Chem.2017, 15(31):6483-6492
  • J Food Sci Technol.2022, 59(1):212-219.
  • J Ethnopharmacol.2018, 210:88-94
  • Chem. of Vegetable Raw Materials2020, 97-105
  • J Pharmaceut Biomed2020, 182:113110
  • J Med Food.2020, 23(6):633-640.
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • ...
  • 生物活性
    Description: Alpha-humulene and trans-caryophyllene extracted from S.officinalis essential oil can inhibit tumor cell growth; they also show marked anti-inflammatory effects, probably by interfering with TNFalpha production.
    Targets: TNF-α
    In vitro:
    An. Real Acad. F., 2010, 76(3):343-56.
    Cytotoxic activity of alpha-humulene and trans-caryophyllene from Salvia officinalis in animal and human tumor cells[Reference: WebLink]
    The purpose of the present work is two-fold: the fractionation of Salvia officinalis essential oil and the cytotoxic study of this oil with its fractions "in vitro" tumor cell lines.
    METHODS AND RESULTS:
    S. officinalis essential oil was obtained by hydrodistillation and fractionated with column chromatography; the essential oil and its fractions were analyzed by gas chromatography (GC) coupled to mass spectrometry (MS). The cytotoxic activity was evaluated in cellular lines of breast cancer MCF-7, colon cancer HCT-116, and murine macrophage RAW264.7 cell lines by the MTT assay Results: the sub-subfraction F1.1.1 of S. officinalis essential oil containing alpha-humulene present highest activity on RAW264.7 and HCT-116 with IC(50) values of 41.9 and 77.3 mu g/ml, respectively. The sub-subfraction F1.2.1 of S. officinalis essential oil with trans-caryophyllene(Alpha-caryophyllene) showed less activity on RAW246.7 and HCT-116 with IC(50) values of 90.5 and 145.8 mu g/ml.
    CONCLUSIONS:
    This paper suggests that the a-humulene and trans-caryophyllene extracted from S.officinalis essential oil inhibit tumor cell growth.
    Medicines (Basel) . 2017 May 25;4(2):34.
    Anti-Inflammatory, Antioxidant, Antibiotic, and Cytotoxic Activities of Tanacetum vulgare L. Essential Oil and Its Constituents[Pubmed: 28930249]
    Abstract Background:Tanacetum vulgare L. (Asteraceae) is a perennial herb that has been used to treat multiple ailments. Regional variability of the chemical composition of T. vulgare essential oils is well-known. Despite these regional chemotypes, most relevant studies did not analyze the complete chemical composition of the T. vulgare essential oil and its constituents in relation to their biological activities. Here, we assess the anti-inflammatory, antioxidant, antibacterial, and cytotoxic activities of T. vulgare collected from northern Quebec (Saguenay-Lac-St-Jean), Canada. Methods: Essential oil was extracted from plants by steam distillation and analyzed using GC-FID. Biological activities of essential oil and its main constituents were evaluated in vitro. Results: We identified the major compounds as camphor, borneol, and 1,8-cineole. The oil possesses anti-inflammatory activity inhibiting NO production. It also inhibits intracellular DCFH oxidation induced by tert-butylhydroperoxide. Anti-inflammatory activity of essential oil appears driven mainly by α-humulene while antioxidant activity is provided by α-pinene and caryophyllene oxide. Essential oil from T vulgare was active against both Escherichia coli and Staphylococcus aureus with camphor and caryophyllene oxide responsible for antibacterial activity. Finally, T. vulgare essential oil was slightly cytotoxic against the human healthy cell line WS1 while α-humulene and caryophyllene oxide were moderately cytotoxic against A-549, DLD-1, and WS1. Conclusion: We report, for the first time, links between the specific compounds found in T. vulgare essential oil and anti-inflammatory, antioxidant, antibacterial, and cytotoxic activities. T. vulgare essential oil possesses interesting biological properties.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.8924 mL 24.4618 mL 48.9237 mL 97.8474 mL 122.3092 mL
    5 mM 0.9785 mL 4.8924 mL 9.7847 mL 19.5695 mL 24.4618 mL
    10 mM 0.4892 mL 2.4462 mL 4.8924 mL 9.7847 mL 12.2309 mL
    50 mM 0.0978 mL 0.4892 mL 0.9785 mL 1.9569 mL 2.4462 mL
    100 mM 0.0489 mL 0.2446 mL 0.4892 mL 0.9785 mL 1.2231 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    反式石竹烯; trans-Caryophyllene CFN90502 87-44-5 C15H24 = 204.36 20mg QQ客服:1413575084
    石竹素; Caryophyllene oxide CFN99239 1139-30-6 C15H24O = 220.4 20mg QQ客服:2932563308
    可布酮; Kobusone CFN98253 24173-71-5 C14H22O2 = 222.3 5mg QQ客服:2932563308
    α-石竹烯; Alpha-caryophyllene CFN93582 6753-98-6 C15H24 = 204.4 20mg QQ客服:1413575084
    花姜酮; Zerumbone CFN91066 471-05-6 C15H22O = 218.3 20mg QQ客服:2932563308
    环氧化蛇麻烯II; Humulene epoxide II CFN98008 19888-34-7 C15H24O = 220.4 5mg QQ客服:1413575084
    十氢-7,7,9a-三甲基-4-亚甲基-6H-环氧乙烯并[5,6]环壬烷并[1,2-b]呋喃-6-酮; Epoxyparvinolide CFN99039 102227-61-2 C15H22O3 = 250.3 5mg QQ客服:2932563308
    大牛儿烯 D; Germacrene D CFN93281 37839-63-7 C15H24 = 204.4 5mg QQ客服:2159513211
    环十五烷酮; Cyclopentadecanone CFN93169 502-72-7 C15H28O = 224.4 20mg QQ客服:3257982914
    麝香酮; Muscone CFN99518 541-91-3 C16H30O = 238.42 20mg QQ客服:1413575084

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