雷公藤春碱

Wilfortrine

	产品编号	CFN92105
	CAS编号	37239-48-8
	分子式 = 分子量	C₄₁H₄₇NO₂₀ = 873.8
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Sesquiterpenoids
	植物来源	The roots of Tripterygium wilfordii Hook. f.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
雷公藤春碱	CFN92105	37239-48-8	1mg	QQ客服：1413575084
雷公藤春碱	CFN92105	37239-48-8	5mg	QQ客服：1413575084
雷公藤春碱	CFN92105	37239-48-8	10mg	QQ客服：1413575084
雷公藤春碱	CFN92105	37239-48-8	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Nicolaus Copernicus Uniwersity (Poland)

National Chung Hsing University (Taiwan)

Biotech R&D Institute (USA)

Helmholtz Zentrum München (Germany)

Uniwersytet Gdański (Poland)

Shanghai Institute of Biochemistry and Cell Biology (China)

Texas A&M University (USA)

Imperial College London (United Kingdom)

Instituto de Investigaciones Agropecuarias (Chile)

Monash University (Australia)

Institute of Pathophysiology Medical University of Vienna (Austria)

University of Illinois (USA)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Universidad de Buenos Aires (Argentina)

More...

Description:

Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic protein Bcl-2 expression. The combined treatment using wilfortrine and paclitaxel can inhibit proliferation and invasion of liver cancer cells via down-regulating Bcl-2 and up-regulating Bax, with better efficacy than single use of either drug. Wilfortrine and euonine (40.80 mg/(kg.d) x 4d ip) show marked depressant effects on humoral mediated immunity using the hemolysin reaction as indices.

Targets:

Bcl-2/Bax | Immunology & Inflammation related

In vitro:

Genet Mol Res. 2015 Nov 30;14(4):15349-55.

Effect of wilfortrine on human hepatic cancer HepG2 cell proliferation potential in vitro.[Pubmed: 26634500 ]

Liver cancers are characterized by high morbidity and mortality owing to few effective drugs for its treatment. Wilfortrine has several pharmacological effects, including an inhibitory effect on liver cancer cell proliferation. However, whether wilfortrine can induce liver cancer cell apoptosis has not been elucidated.
METHODS AND RESULTS:
We investigated the role of wilfortrine on liver cancer cell HepG2 apoptosis and analyzed its possible mechanisms to provide a theoretical basis for clinical analysis of liver cancer pathogenesis. The liver cancer cell line HepG2 was treated with 40 mM wilfortrine for 48 h. Flow cytometry was applied to detect HepG2 cell apoptosis and cell cycle changes. Western blot was used to analyze Bcl-2 and Bax expression. The HepG2 cell apoptosis rate increased significantly after treatment with wilfortrine, especially the early apoptosis rate (P < 0.05). However, wilfortrine did not change the cell cycle of HepG2 cells. After wilfortrine treatment, Bcl- 2 expression decreased significantly (P < 0.05); on the contrary, Bax expression increased noticeably compared with the control group (P < 0.05).
CONCLUSIONS:
Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic protein Bcl-2 expression.

In vivo:

Yao Xue Xue Bao. 1989;24(8):568-72.

Immunosuppresive effects of wilfortrine and euonine.[Pubmed: 2618700]

Wifortrine and Euonine isolated from Tripterygium wilfordii Hook. f.
METHODS AND RESULTS:
Wilfortrine and euonine (40.80 mg/(kg.d) x 4d ip) showed marked depressant effects on humoral mediated immunity using the hemolysin reaction as indices. Wilfortrine (160 mg/kg.d x 9d ip) exhibited a depressant effect on graft vs host reaction (GVHR), but wilfortrine (80 mg/(kg.d) x 9d ip) showed no definite effect. Euonine (80 mg/(kg.d) x 10d ip) showed marked suppressant effects on DNCB induced delayed hypersensitivity reaction on skin in mice. Wilfortrine and Euonine (80 mg/(kg.d) x 4d ip) significantly decreased the clearance rate of charcoal particles and the weights of spleen and thymus.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
黑蔓定碱; Regelidine	CFN92115	114542-54-0	C₃₅H₃₇NO₈ = 599.7	5mg	QQ客服：1457312923
雷公藤新碱; Evonimine	CFN92102	41758-69-4	C₃₈H₄₇NO₁₈ = 805.8	5mg	QQ客服：215959384
Aquifoliunine E-III; Aquifoliunine E-III	CFN92117	220751-20-2	C₃₆H₄₅NO₁₇ = 763.8	5mg	QQ客服：2056216494
卫矛羰碱; Evonine	CFN92107	33458-82-1	C₃₈H₄₇NO₁₈ = 805.8	5mg	QQ客服：1457312923
Hypoglaunine A; Hypoglaunine A	CFN92106	228259-16-3	C₄₁H₄₇NO₂₀ = 873.8	5mg	QQ客服：215959384
雷公藤春碱; Wilfortrine	CFN92105	37239-48-8	C₄₁H₄₇NO₂₀ = 873.8	5mg	QQ客服：2159513211
雷公藤晋碱; Wilforgine	CFN98605	37239-47-7	C₄₁H₄₇NO₁₉ = 857.8	20mg	QQ客服：3257982914
Triptonine B; Triptonine B	CFN92116	168009-85-6	C₄₆H₄₉NO₂₂ = 967.9	5mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1444 mL	5.7221 mL	11.4443 mL	22.8885 mL	28.6107 mL
5 mM	0.2289 mL	1.1444 mL	2.2889 mL	4.5777 mL	5.7221 mL
10 mM	0.1144 mL	0.5722 mL	1.1444 mL	2.2889 mL	2.8611 mL
50 mM	0.0229 mL	0.1144 mL	0.2289 mL	0.4578 mL	0.5722 mL
100 mM	0.0114 mL	0.0572 mL	0.1144 mL	0.2289 mL	0.2861 mL

雷公藤春碱

Wilfortrine

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