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  • 雷公藤晋碱

    Wilforgine

    雷公藤晋碱
    产品编号 CFN98605
    CAS编号 37239-47-7
    分子式 = 分子量 C41H47NO19 = 857.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Tripterygium wilfordii Hook. f.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    雷公藤晋碱 CFN98605 37239-47-7 10mg QQ客服:2159513211
    雷公藤晋碱 CFN98605 37239-47-7 20mg QQ客服:2159513211
    雷公藤晋碱 CFN98605 37239-47-7 50mg QQ客服:2159513211
    雷公藤晋碱 CFN98605 37239-47-7 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • ...
  • 生物活性
    Description: Wilforgine exhibits insecticidal activity of some degree.
    In vitro:
    Curr Microbiol. 2015 Apr;70(4):571-9.
    Effects of plant stress signal molecules on the production of wilforgine in an endophytic actinomycete isolated from Tripterygium wilfordii Hook.f.[Pubmed: 25523369]
    The endophytic actinomycete F4-20 was isolated from Tripterygium wilfordii Hook.f. and was confirmed to produce wilforgine, a secondary metabolite discovered in its host.
    METHODS AND RESULTS:
    F4-20 showed a close phylogenetic relationship to Streptomyces species.
    METHODS AND RESULTS:
    To seek elicitors that may enhance the production of wilforgine in F4-20, four plant stress molecules were applied to the in vitro liquid cultures. Results showed that methyl jasmonate (MeJA), salicylic acid (SA), and hydrogen peroxide (H2O2) inhibited bacterial growth, whereas glutathione (GSH) treatment significantly increased bacterial growth. The wilforgine contents in the mycelia of F4-20 were reduced by MeJA and GSH but were induced by SA and H2O2. When added in the end of the culture period (7 day), 1 mM SA and 5 mM H2O2 resulted in 69.35 ± 1.71 and 71.80 ± 3.35 µg/g DW of wilforgine production, 1.55 and 1.60 fold to that of control (44.83 ± 1.35 µg/g DW), respectively.
    CONCLUSIONS:
    Though this improved production was about 6.5 times lower than that of the natural root (454.00 µg/g dry root bark), it provided an alternative method for the production of valuable plant secondary metabolites.
    Acta Entomologica Sinica,2007,50(8):795-800.
    Insecticidal activities and active ingredients of Tripterygium hypoglaucum (Levl.) Hutch[Reference: WebLink]
    Isolating insecticidal activities compounds is an important method to discover new pesticides.
    METHODS AND RESULTS:
    Insecticidal activities and active ingredients of Tripterygium hypoglaucum against six lepidopteran insects were studied with bioassay-guided fractionation methods. The results showed the petroleum extract, methanol extract and acetic ether extract of the root of T. hypoglaucum had antifeedant activity against the 3th instar larvae of Mythimna separata Walker, with the AFC_ 50 value 1 165.7 μg/mL, 104.3 μg/mL and 47.3 μg/mL 24 h after treatment, respectively. The methanol extract of the root bark had contact toxicity to the 4th instar larvae of M. separatar, with the LD_ 50 values 100.4 μg/larva 24 h after treatment. Four sesquiterpenes pyridine alkaloids, i.e., wilfortrine, Wilforgine, wilfordine and wilforine, were isolated from the methanol extract of the root bark of T. hypoglaucum by bioassay-guided fractionation. The bioassay results showed that wilfortrine and Wilforgine had stomach toxicity with the ND_ 50 value 18.1 μg/larva and 7.4 μg/larva, respectively against M. separata; wilfordine and wilforine had topical toxicity with the ND_ 50 value 0.33 μg/larva and 0.06 μg/larva, respectively against M. separata and stomach toxicity with the ND_ 50 value 5.62 μg/larva and 1.24 μg/larva, respectively against Agrotis ypsilon.
    CONCLUSIONS:
    T. hypoglaucum exhibited insecticidal activity of some degree against the all six lepidopteran insects tested, and the main active ingredients were wilfortrine, Wilforgine, wilfordine and wilforine.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1658 mL 5.8289 mL 11.6577 mL 23.3155 mL 29.1443 mL
    5 mM 0.2332 mL 1.1658 mL 2.3315 mL 4.6631 mL 5.8289 mL
    10 mM 0.1166 mL 0.5829 mL 1.1658 mL 2.3315 mL 2.9144 mL
    50 mM 0.0233 mL 0.1166 mL 0.2332 mL 0.4663 mL 0.5829 mL
    100 mM 0.0117 mL 0.0583 mL 0.1166 mL 0.2332 mL 0.2914 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    黑蔓定碱; Regelidine CFN92115 114542-54-0 C35H37NO8 = 599.7 5mg QQ客服:3257982914
    雷公藤新碱; Evonimine CFN92102 41758-69-4 C38H47NO18 = 805.8 5mg QQ客服:1457312923
    Aquifoliunine E-III; Aquifoliunine E-III CFN92117 220751-20-2 C36H45NO17 = 763.8 5mg QQ客服:1413575084
    卫矛羰碱; Evonine CFN92107 33458-82-1 C38H47NO18 = 805.8 5mg QQ客服:1413575084
    Hypoglaunine A; Hypoglaunine A CFN92106 228259-16-3 C41H47NO20 = 873.8 5mg QQ客服:1457312923
    雷公藤春碱; Wilfortrine CFN92105 37239-48-8 C41H47NO20 = 873.8 5mg QQ客服:1457312923
    雷公藤晋碱; Wilforgine CFN98605 37239-47-7 C41H47NO19 = 857.8 20mg QQ客服:215959384
    Triptonine B; Triptonine B CFN92116 168009-85-6 C46H49NO22 = 967.9 5mg QQ客服:215959384

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