Info: Read More
  • 中药标准品生产商,产品定制服务
  • 乙酰白藜芦醇

    Triacetylresveratrol

    乙酰白藜芦醇
    产品编号 CFN90895
    CAS编号 42206-94-0
    分子式 = 分子量 C20H18O6 = 354.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The rhizomes of Polygonum cuspidatum Sieb. et Zucc.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    乙酰白藜芦醇 CFN90895 42206-94-0 10mg QQ客服:1148253675
    乙酰白藜芦醇 CFN90895 42206-94-0 20mg QQ客服:1148253675
    乙酰白藜芦醇 CFN90895 42206-94-0 50mg QQ客服:1148253675
    乙酰白藜芦醇 CFN90895 42206-94-0 100mg QQ客服:1148253675
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • The Institute of Cancer Research (United Kingdom)
  • Univerzita Karlova v Praze (Czech Republic)
  • Wageningen University (Netherlands)
  • University of Illinois (USA)
  • Yale University (USA)
  • Complutense University of Madrid (Spain)
  • Ain Shams University (Egypt)
  • University of Perugia (Italy)
  • S.N.D.T. Women's University (India)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Kyung Hee University (Korea)
  • University of South Australia (Australia)
  • Universidad Veracuzana (Mexico)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(11):14105-21
  • Fitoterapia.2022, 157:105130.
  • Horticulturae2021, 7(1),5.
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Molecules.2020, 25(11):2599.
  • Sci Rep.2018, 8:9267
  • Nutrients.2018, 10(7)
  • Oxid Med Cell Longev.2020, 2020:8887251.
  • J Mol Histol.2019, 50(4):343-354
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Korean J Dent Mater2020, 47(2):63-70.
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Molecules2020, 25(4):892
  • Toxins (Basel).2021, 13(12):898.
  • Srinagarind Medical Journal2017, 32(1)
  • Chin Med.2022, 17(1):66.
  • Biomedicines.2022, 10(2):463.
  • Food and Chemical Toxicology2020, 111221
  • Plants (Basel).2021, 10(6):1119.
  • Appl. Sci.2020, 10(16),5482.
  • Front Pharmacol.2022, 13:806869.
  • Cardiovasc Toxicol.2021, 21(11):947-963.
  • Nutrients.2018, 11(1):E17
  • ...
  • 生物活性
    Description: Triacetylresveratrol has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells.
    Targets: STAT | NF-kB | Mcl-1 | Bim | Puma
    In vitro:
    Sci Rep. 2016 Aug 19;6:31672.
    In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells.[Pubmed: 27539371]
    Resveratrol (RES) has been studied extensively as an anticancer agent. However, the anticancer effects of Triacetylresveratrol (TRES, an acetylated analog of RES) which has higher bioavailability have not been well established.
    METHODS AND RESULTS:
    We comparatively evaluated their effects on cell proliferation, apoptosis and the molecular changes in STAT3, NFκB and apoptotic signaling pathways in pancreatic cancer cells. Apoptosis was determined by flow cytometry. The nuclear translocation and interaction of STAT3 and NFκB were detected by Western blotting and immunoprecipitation, respectively. Both TRES and RES inhibited cell viability, and induced apoptosis of pancreatic cancer cells in a concentration and incubation time-dependent manner. TRES, similarly to RES, inhibited the phosphorylation of STAT3 and NFκB, down-regulated Mcl-1, and up-regulated Bim and Puma in pancreatic cancer cells.
    CONCLUSIONS:
    Remarkably, we, for the first time, observed that both TRES and RES suppressed the nuclear translocation, and interrupted the interaction of STAT3 and NFκB in PANC-1 cells. Comparative anticancer effects of TRES and RES on pancreatic cancer suggested that TRES with higher bioavailability may be a potential agent for pancreatic cancer prevention and treatment. Further in vivo experiments and functional studies are warranted to investigate whether TRES exhibits better beneficial effects than RES in mice and humans.
    Oncotarget. 2015 Jul 30;6(21):18282-92.
    Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions.[Pubmed: 26286961]
    Tumor growth is not solely a consequence of autonomous tumor cell properties. Rather, tumor cells act upon and are acted upon by their microenvironment. It is tumor tissue biology that ultimately determines tumor growth. Thus, we developed a compound library screen for agents that could block essential tumor-promoting effects of the glioblastoma (GBM) perivascular stem cell niche (PVN). We modeled the PVN with three-dimensional primary cultures of human brain microvascular endothelial cells in Matrigel. We previously demonstrated stimulated growth of GBM cells in this PVN model and used this to assay PVN function.
    METHODS AND RESULTS:
    We screened the Microsource Spectrum Collection library for drugs that specifically blocked PVN function, without any direct effect on GBM cells themselves. Three candidate PVN-disrupting agents, Iridin, Tigogenin and Triacetylresveratrol (TAR), were identified and evaluated in secondary in vitro screens against a panel of primary GBM isolates as well as in two different in vivo intracranial models. Iridin and TAR significantly inhibited intracranial tumor growth and prolonged survival in these mouse models.
    CONCLUSIONS:
    Together these data identify Iridin and TAR as drugs with novel GBM tissue disrupting effects and validate the importance of preclinical screens designed to address tumor tissue function rather than the mechanisms of autonomous tumor cell growth.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8217 mL 14.1084 mL 28.2167 mL 56.4334 mL 70.5418 mL
    5 mM 0.5643 mL 2.8217 mL 5.6433 mL 11.2867 mL 14.1084 mL
    10 mM 0.2822 mL 1.4108 mL 2.8217 mL 5.6433 mL 7.0542 mL
    50 mM 0.0564 mL 0.2822 mL 0.5643 mL 1.1287 mL 1.4108 mL
    100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5643 mL 0.7054 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    土大黄苷 6''-O-没食子酸酯; Rhaponticin 6''-O-gallate CFN91099 94356-23-7 C28H28O13 = 572.51 5mg QQ客服:1413575084
    土大黄苷 2''-O-没食子酸酯; Rhaponticin 2''-O-gallate CFN91100 94356-24-8 C28H28O13 = 572.51 5mg QQ客服:2932563308
    2,3,5,4-四羟基二苯乙烯葡萄糖苷; 2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside CFN99995 82373-94-2 C20H22O9 = 406.39 20mg QQ客服:1413575084
    松茋; Pinostilbene CFN98662 42438-89-1 C15H14O3 = 242.3 5mg QQ客服:2159513211
    1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6→1)-O-α-L-rhamnopyranosyl]phenylethane; 1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6->1)-O-alpha-L-rhamnopyranosyl]phenylethane CFN95285 1338076-61-1 C28H38O12 = 566.6 5mg QQ客服:1413575084
    Pinostilbenoside; Pinostilbenoside CFN98995 58762-96-2 C21H24O8 = 404.4 5mg QQ客服:2159513211
    3-羟基-5-甲氧基二苯乙烯; 5-Methoxy-3-stilbenol CFN92587 5150-38-9 C15H14O2 = 226.3 5mg QQ客服:2159513211
    Thunalbene; Thunalbene CFN92783 220862-05-5 C15H14O3 = 242.3 5mg QQ客服:1148253675
    3'-O-甲基山药素III; 3'-O-Methylbatatasin III CFN91176 101330-69-2 C16H18O3 = 258.3 10mg QQ客服:3257982914
    山药素 III; Batatasin III CFN92689 56684-87-8 C15H16O3 = 244.3 5mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产