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  • 中药标准品生产商,产品定制服务
  • 乙酰白藜芦醇


    产品编号 CFN90895
    CAS编号 42206-94-0
    分子式 = 分子量 C20H18O6 = 354.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The rhizomes of Polygonum cuspidatum Sieb. et Zucc.
    产品名称 产品编号 CAS编号 包装 QQ客服
    乙酰白藜芦醇 CFN90895 42206-94-0 10mg QQ客服:1148253675
    乙酰白藜芦醇 CFN90895 42206-94-0 20mg QQ客服:1148253675
    乙酰白藜芦醇 CFN90895 42206-94-0 50mg QQ客服:1148253675
    乙酰白藜芦醇 CFN90895 42206-94-0 100mg QQ客服:1148253675
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • The Institute of Cancer Research (United Kingdom)
  • Univerzita Karlova v Praze (Czech Republic)
  • Wageningen University (Netherlands)
  • University of Illinois (USA)
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  • Complutense University of Madrid (Spain)
  • Ain Shams University (Egypt)
  • University of Perugia (Italy)
  • S.N.D.T. Women's University (India)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Kyung Hee University (Korea)
  • University of South Australia (Australia)
  • Universidad Veracuzana (Mexico)
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  • ...
  • 生物活性
    Description: Triacetylresveratrol has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells.
    Targets: STAT | NF-kB | Mcl-1 | Bim | Puma
    In vitro:
    Sci Rep. 2016 Aug 19;6:31672.
    In vitro comparative studies of resveratrol and triacetylresveratrol on cell proliferation, apoptosis, and STAT3 and NFκB signaling in pancreatic cancer cells.[Pubmed: 27539371]
    Resveratrol (RES) has been studied extensively as an anticancer agent. However, the anticancer effects of Triacetylresveratrol (TRES, an acetylated analog of RES) which has higher bioavailability have not been well established.
    We comparatively evaluated their effects on cell proliferation, apoptosis and the molecular changes in STAT3, NFκB and apoptotic signaling pathways in pancreatic cancer cells. Apoptosis was determined by flow cytometry. The nuclear translocation and interaction of STAT3 and NFκB were detected by Western blotting and immunoprecipitation, respectively. Both TRES and RES inhibited cell viability, and induced apoptosis of pancreatic cancer cells in a concentration and incubation time-dependent manner. TRES, similarly to RES, inhibited the phosphorylation of STAT3 and NFκB, down-regulated Mcl-1, and up-regulated Bim and Puma in pancreatic cancer cells.
    Remarkably, we, for the first time, observed that both TRES and RES suppressed the nuclear translocation, and interrupted the interaction of STAT3 and NFκB in PANC-1 cells. Comparative anticancer effects of TRES and RES on pancreatic cancer suggested that TRES with higher bioavailability may be a potential agent for pancreatic cancer prevention and treatment. Further in vivo experiments and functional studies are warranted to investigate whether TRES exhibits better beneficial effects than RES in mice and humans.
    Oncotarget. 2015 Jul 30;6(21):18282-92.
    Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions.[Pubmed: 26286961]
    Tumor growth is not solely a consequence of autonomous tumor cell properties. Rather, tumor cells act upon and are acted upon by their microenvironment. It is tumor tissue biology that ultimately determines tumor growth. Thus, we developed a compound library screen for agents that could block essential tumor-promoting effects of the glioblastoma (GBM) perivascular stem cell niche (PVN). We modeled the PVN with three-dimensional primary cultures of human brain microvascular endothelial cells in Matrigel. We previously demonstrated stimulated growth of GBM cells in this PVN model and used this to assay PVN function.
    We screened the Microsource Spectrum Collection library for drugs that specifically blocked PVN function, without any direct effect on GBM cells themselves. Three candidate PVN-disrupting agents, Iridin, Tigogenin and Triacetylresveratrol (TAR), were identified and evaluated in secondary in vitro screens against a panel of primary GBM isolates as well as in two different in vivo intracranial models. Iridin and TAR significantly inhibited intracranial tumor growth and prolonged survival in these mouse models.
    Together these data identify Iridin and TAR as drugs with novel GBM tissue disrupting effects and validate the importance of preclinical screens designed to address tumor tissue function rather than the mechanisms of autonomous tumor cell growth.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8217 mL 14.1084 mL 28.2167 mL 56.4334 mL 70.5418 mL
    5 mM 0.5643 mL 2.8217 mL 5.6433 mL 11.2867 mL 14.1084 mL
    10 mM 0.2822 mL 1.4108 mL 2.8217 mL 5.6433 mL 7.0542 mL
    50 mM 0.0564 mL 0.2822 mL 0.5643 mL 1.1287 mL 1.4108 mL
    100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5643 mL 0.7054 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    土大黄苷 6''-O-没食子酸酯; Rhaponticin 6''-O-gallate CFN91099 94356-23-7 C28H28O13 = 572.51 5mg QQ客服:1413575084
    土大黄苷 2''-O-没食子酸酯; Rhaponticin 2''-O-gallate CFN91100 94356-24-8 C28H28O13 = 572.51 5mg QQ客服:2932563308
    2,3,5,4-四羟基二苯乙烯葡萄糖苷; 2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside CFN99995 82373-94-2 C20H22O9 = 406.39 20mg QQ客服:1413575084
    松茋; Pinostilbene CFN98662 42438-89-1 C15H14O3 = 242.3 5mg QQ客服:2159513211
    1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6→1)-O-α-L-rhamnopyranosyl]phenylethane; 1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6->1)-O-alpha-L-rhamnopyranosyl]phenylethane CFN95285 1338076-61-1 C28H38O12 = 566.6 5mg QQ客服:1413575084
    Pinostilbenoside; Pinostilbenoside CFN98995 58762-96-2 C21H24O8 = 404.4 5mg QQ客服:2159513211
    3-羟基-5-甲氧基二苯乙烯; 5-Methoxy-3-stilbenol CFN92587 5150-38-9 C15H14O2 = 226.3 5mg QQ客服:2159513211
    Thunalbene; Thunalbene CFN92783 220862-05-5 C15H14O3 = 242.3 5mg QQ客服:1148253675
    3'-O-甲基山药素III; 3'-O-Methylbatatasin III CFN91176 101330-69-2 C16H18O3 = 258.3 10mg QQ客服:3257982914
    山药素 III; Batatasin III CFN92689 56684-87-8 C15H16O3 = 244.3 5mg QQ客服:1413575084





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