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  • 虎杖甙


    产品编号 CFN99159
    CAS编号 27208-80-6
    分子式 = 分子量 C20H22O8 = 390.40
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Polyphenols
    植物来源 The rhizomes of Polygonum cuspidatum Sieb. et Zucc.
    产品名称 产品编号 CAS编号 包装 QQ客服
    虎杖甙 CFN99159 27208-80-6 10mg QQ客服:1148253675
    虎杖甙 CFN99159 27208-80-6 20mg QQ客服:1148253675
    虎杖甙 CFN99159 27208-80-6 50mg QQ客服:1148253675
    虎杖甙 CFN99159 27208-80-6 100mg QQ客服:1148253675
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Universit?t Basel (Switzerland)
  • Almansora University (Egypt)
  • University of Vigo (Spain)
  • Universite de Lille1 (France)
  • Worcester Polytechnic Institute (USA)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Universidad Industrial de Santander (Colombia)
  • Biotech R&D Institute (USA)
  • University of Liège (Belgium)
  • Florida A&M University (USA)
  • University of Indonesia (Indonesia)
  • University of Minnesota (USA)
  • Indian Institute of Science (India)
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  • ...
  • 生物活性
    Description: Polydatin has antioxidant, anti-inflammatory, neuroprotection and anti-cancer activities, which has favorable potency to develop a hypolipemic and/or hepatoprotective agent in clinic. It is a mitochondria protector for acute severe hemorrhagic shock treatment, the neuronal mitochondrial injury is involved in the genesis of severe shock. Polydatin has a protective effect against ischemia/reperfusion injury in rat heart, the cardioprotection of polydatin is mainly mediated by cNOS which leading to an increase in NO production.
    Targets: NF-kB | NOS | MAPK | TNF-α | IL Receptor | LTR | Akt | Bcl-2/Bax | NO
    In vitro:
    Inflammation. 2015 Jan 8.
    Inhibitory Effects of Polydatin on Lipopolysaccharide-Stimulated RAW 264.7 Cells.[Pubmed: 25567371]
    The purpose of this study was to evaluate the effects of polydatin (PD) on cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expressions at protein and transcriptional levels, as well as the production of prostaglandin E2 (PGE2) and nitric oxide (NO) in lipopolysaccharide (LPS)-induced macrophage RAW 264.7 cells.
    To elucidate the underlying mechanism responsible for these symptoms, we investigated the phosphorylation of mitogen-activated protein kinase (MAPK) pathway and nuclear factor-κB (NF-κB) expression. NO was analyzed with the Griess method. PGE2 was measured by enzyme-linked immunosorbent assay (ELISA). iNOS and COX-2 messenger RNA (mRNA) were identified by qPCR assay. iNOS, COX-2, NF-κB, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 protein expressions were detected with Western blot. The results revealed that PD effectively inhibited NO and PGE2 production, and it is not surprising that PD reduced iNOS and COX-2 expression at protein and transcriptional levels. Additionally, PD significantly ameliorated the activation of NF-κB and the phosphorylation of MAPKs in LPS-induced RAW 264.7 macrophages.
    These findings suggested that PD exerted potent anti-inflammatory activity in macrophages.
    Cell Death Dis . 2018 May 1;9(5):572.
    A new inhibitor of glucose-6-phosphate dehydrogenase blocks pentose phosphate pathway and suppresses malignant proliferation and metastasis in vivo[Pubmed: 29760380]
    Abstract Pentose phosphate pathway (PPP) is a major glucose metabolism pathway, which has a fundamental role in cancer growth and metastasis. Even though PPP blockade has been pointed out as a very promising strategy against cancer, effective anti-PPP agents are not still available in the clinical setting. Here we demonstrate that the natural molecule polydatin inhibits glucose-6-phosphate dehydrogenase (G6PD), the key enzyme of PPP. Polydatin blocks G6PD causing accumulation of reactive oxygen species and strong increase of endoplasmic reticulum stress. These effects are followed by cell cycle block in S phase, an about 50% of apoptosis, and 60% inhibition of invasion in vitro. Accordingly, in an orthotopic metastatic model of tongue cancer, 100 mg/kg polydatin induced an about 30% tumor size reduction with an about 80% inhibition of lymph node metastases and 50% reduction of lymph node size (p < 0.005). Polydatin is not toxic in animals up to a dose of 200 mg/kg and a phase II clinical trial shows that it is also well tolerated in humans (40 mg twice a day for 90 days). Thus, polydatin may be used as a reliable tool to limit human cancer growth and metastatic spread.
    In vivo:
    Zhongguo Zhong Yao Za Zhi. 2014 Aug;39(16):3157-61.
    Inhibitory effect of polydatin on expression of toll-like receptor 4 in ischemia-reperfusion injured NRK-52E cells.[Pubmed: 25509306]
    Polydatin is a monocrystaline compound isolated from Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae) with biological properties, such as anti-inflammation, anti-oxidative and nephroprotective effects. Increasing number of studies have demonstrated the protective effect of polydatin on renal ischemia reperfusion injury. However, the possible mechanisms of this protection are not fully elucidated.
    This study aimed to investigate the effect of polydatin on ischemia-reperfusion induced expression of toll-like receptor4 (TLR4) in rat renal tubular epithelia cells (NRK-52E), and analyze the mechanism of polydatin on TLR4 signal pathway. The cultured NRK-52E cells were incubated in three gas incubators for a period of 6 h at hypoxia and 24h at reoxygenation to simulate the ischemia-reperfusion injury in vitro. TLR4 mRNA level was analyzed by real-time-PCR, and the protein expression of TLR4 and NF-κB by Western blotting, while TNF-α and IL-1β proteins expressions were detected by ELISA. Polydatin downregulated I/R induced mRNA and protein expressions of TLR4, and decreased the protein expression of NF-κB, TNF-α and IL-1β. The TLR4 blocker partially antagonized the effect of I/R on NF-κB signaling, and such inhibitory effect was markedly enhanced by polydatin.
    In the present study, polydatin protects NRK-52E cells from I/R injury possibly by relieving the inflammatory response through regulation of TLR4/NF-κB signaling pathway.
    Biomed Pharmacother. 2009 Aug;63(7):457-62.
    Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits.[Pubmed: 18657948]
    Hyperlipidemia is one of the vital coronary risk factors and is positively related to morbidity and mortality of coronary heart disease. There are numerous herbal medicines which are reported to exert good hypolipidemic actions with few side effects.
    In the present study, the hypolipidemic effects of polydatin, a compound from Polygonum cuspidatum Sieb. et Zucc, on hyperlipidemic rabbits were evaluated. Thirty-two male rabbits were fed a high fat/cholesterol diet for 6 weeks and another eight male rabbits fed a basic diet served as normal control. Three weeks after a high fat/cholesterol diet, the animals were orally administrated polydatin (25, 50, and 100 mg kg(-1) per day) by intubation for 3 weeks. The results showed that polydatin markedly decreased the serum levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) in hyperlipidemic rabbits. The ratio of TC to high-density lipoprotein cholesterol (HDL-C) and the liver coefficient were also reduced. But both polydatin and high fat/cholesterol diet did not evidently affect body weight in hyperlipidemic rabbits.
    All these results suggest that polydatin from Polygonum cuspidatum has favorable potency to develop a hypolipemic and/or hepatoprotective agent in clinic. However the mechanism of hypolipemic action of polydatin is in need of further clarity.
    Sheng Li Xue Bao. 2008 Apr 25;60(2):161-8.
    Protective effect of polydatin against ischemia/reperfusion injury in rat heart.[Pubmed: 18425301]
    The aim of the present study was to investigate the protective effect of polydatin against myocardial ischemia/reperfusion injury in rats and the underlying mechanism.
    In anesthetized rats, ischemia and reperfusion arrhythmia produced by ligating and loosing the coronary artery was recorded and myocardial infarct size was measured. In Langendorff isolated rat heart, cardiac function was recorded before and after 30 min of global ischemia followed by 60 min of reperfusion. The parameters of cardiac function include left ventricular developed pressure (LVDP), maximal differentials of LVDP (±LVdp/dt(max)) and coronary flow (CF) were measured. Myocardial superoxide dismutase (SOD) activity, the contents of myocardial malondialdehyde (MDA) and nitric oxide (NO) as well as the activity of nitric oxide synthase (NOS) were measured in isolated heart. The results showed: (1) Arrhythmia score and myocardial infarct size were significantly lower in polydatin group than that in the control group (P<0.05, P<0.01); (2) The recovery of LVDP, ±LVdp/dt(max) and CF during reperfusion in polydatin group were significantly better than that in the control rats (P<0.05, P<0.01); (3) SOD activity in polydatin group was significantly higher than that in the control group, but MDA content was lower in polydatin group than that in the control group (P<0.05); (4) NO content and NOS activity, especially constitutive nitric oxide synthase (cNOS) activity in polydatin group were higher than that in the control group (P<0.05); (5) L-NAME, the NOS inhibitor, reversed the protective effect of polydatin against ischemia/reperfusion injury.
    The results suggest that polydatin has a protective effect against ischemia/reperfusion injury in rat heart. The cardioprotection of polydatin is mainly mediated by cNOS which leading to an increase in NO production.
    Fundam Clin Pharmacol . 2017 Jun;31(3):280-291.
    Synergistic effects of polydatin and vitamin C in inhibiting cardiotoxicity induced by doxorubicin in rats[Pubmed: 27891661]
    Abstract The purpose of this study was to assess the synergistic effect of polydatin and vitamin C on attenuating cardiotoxicity induced by doxorubicin (DOX) in rats. Polydatin could significantly increase the activity of superoxide dismutase (SOD) and the heart rate, attenuate myocardial pathological damage, decrease malondialdehyde (MDA) content, slightly increase arterial pressure and glutathione peroxidase (GSH-Px) activity, reduce intervals of QRS, QT, and ST, and lower free fatty acid (FFA) content. The combination of polydatin and vitamin C could significantly increase arterial pressure and heart rate, decrease QRS interval and slightly reduce ST and QT intervals, significantly attenuate myocardial pathological damage, increase the activities of GSH-Px,T-SOD, Na+ K+ -ATPase, and Ca2+ Mg2+ -ATPase, elevate phosphocreatine (PCr) and adenosine triphosphate (ATP) contents, slightly increase adenosine diphosphate (ADP) and total adenine nucleotide (TAN) contents and PCr/ATP, and significantly decrease the contents of MDA and FFA, when compared with those in the DOX group. Meanwhile, the improvement effects on FFA content, the activities of ATPase and SOD, and contents of ATP and TAN in combination group were more obvious than those in polydatin group, and the improvement effects on arterial pressure, heart rate, interval of QRS, GSH-Px activity, and MDA, ADP, and PCr contents in combination group were slightly obvious when compared with those in polydatin group. In addition, the mRNA expression levels of AMPK-α2 and PPAR-α were slightly improved in combination group. The results illustrate that the combination of polydatin and vitamin C has the ability to enhance the myocardial protective effects by its antioxidative effect and improve energy metabolism. Keywords: cardiomyopathy; energy metabolism; oxidative stress; polydatin; vitamin C.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5615 mL 12.8074 mL 25.6148 mL 51.2295 mL 64.0369 mL
    5 mM 0.5123 mL 2.5615 mL 5.123 mL 10.2459 mL 12.8074 mL
    10 mM 0.2561 mL 1.2807 mL 2.5615 mL 5.123 mL 6.4037 mL
    50 mM 0.0512 mL 0.2561 mL 0.5123 mL 1.0246 mL 1.2807 mL
    100 mM 0.0256 mL 0.1281 mL 0.2561 mL 0.5123 mL 0.6404 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Arundinin; Arundinin CFN91179 148225-38-1 C22H22O4 = 350.4 5mg QQ客服:3257982914
    2-(2,4-Dihydroxyphenyl)-5,6-methylenedioxybenzofuran (ABF); 2-(2,4-Dihydroxyphenyl)-5,6-methylenedioxybenzofuran (ABF) CFN95511 67121-26-0 C15H10O5 = 270.2 5mg QQ客服:1413575084
    白藜芦醇; Resveratrol CFN98791 501-36-0 C14H12O3 = 228.2 20mg QQ客服:1148253675
    乙酰白藜芦醇; Triacetylresveratrol CFN90895 42206-94-0 C20H18O6 = 354.4 20mg QQ客服:3257982914
    虎杖甙; Polydatin CFN99159 27208-80-6 C20H22O8 = 390.40 20mg QQ客服:2159513211
    白藜芦醇-3-O-β-D-(2''-O-没食子酰)-葡萄糖苷; Pieceid-2''-O-gallate CFN95226 105304-51-6 C27H26O12 = 542.5 10mg QQ客服:2159513211
    二氢藜芦醇; Dihydroresveratrol CFN98987 58436-28-5 C14H14O3 = 230.3 20mg QQ客服:1413575084
    二氢白藜芦醇3-O-葡萄糖甙; Dihydroresveratrol 3-O-glucoside CFN99021 100432-87-9 C20H24O8 = 392.4 5mg QQ客服:2159513211
    去氧土大黄苷元; Desoxyrhapontigenin CFN90854 33626-08-3 C15H14O3 = 242.3 10mg QQ客服:1148253675
    去氧土大黄苷; Desoxyrhaponticin CFN90911 30197-14-9 C21H24O8 = 404.4 20mg QQ客服:215959384





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