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  • 去氧土大黄苷

    Desoxyrhaponticin

    去氧土大黄苷
    产品编号 CFN90911
    CAS编号 30197-14-9
    分子式 = 分子量 C21H24O8 = 404.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The roots of Rumex obtusifolius L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    去氧土大黄苷 CFN90911 30197-14-9 10mg QQ客服:2159513211
    去氧土大黄苷 CFN90911 30197-14-9 20mg QQ客服:2159513211
    去氧土大黄苷 CFN90911 30197-14-9 50mg QQ客服:2159513211
    去氧土大黄苷 CFN90911 30197-14-9 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Appl Toxicol.2020, 40(7):965-978.
  • Microchemical Journal2022, 182: 107874.
  • Oncotarget.2017, 8(64):108006-108019
  • Indian J. of Experimental Bio.2020, 9(58).
  • Food Chem Toxicol.2023, 176:113802.
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  • HIV Med.2021, 22(8):690-704.
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  • Preprints2022, 202211.0388.v1.
  • J Cell Mol Med . 2023, jcmm.17954.
  • Universitat Stuttgart2022, opus-12200.
  • Int J Mol Sci.2022, 23(23):15213.
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  • ...
  • 生物活性
    Description: Desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes. Desoxyrhaponticin could be considered as a promising fatty acid synthase(FAS) inhibitor, it could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells.
    Targets: Fatty Acid Synthase
    In vitro:
    Food & Function, 2014 , 5 (2) :251-6.
    Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells.[Pubmed: 24362821]
    Fatty acid synthase (FAS) has attracted more and more attention as a potential target for cancer treatment. Natural FAS inhibitors are emerging as potential therapeutic agents to treat cancer. Rheum tanguticum Maxim. ex Balf. (rhubarb) is a traditional Chinese nutritional food and has been reported to possess a variety of biological activities, including the ability to induce the apoptosis of cancer cells.
    METHODS AND RESULTS:
    This study indicates that desoxyrhaponticin (DC) and rhaponticin (RC), two stilbene glycosides from rhubarb, could be considered as promising FAS inhibitors. We found that both DC and RC could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells. In addition, the apoptotic effect of DC on human cancer cells was announced for the first time.
    CONCLUSIONS:
    Since FAS plays a key role in the biosynthesis pathway of fatty acids in cancer cells, these findings suggest that DC has potential applications in the prevention and treatment of cancer.
    In vivo:
    J Pharmacol Exp Ther. 2007 Jan;320(1):38-46.
    Desoxyrhaponticin (3,5-dihydroxy-4'-methoxystilbene 3-O-beta-D-glucoside) inhibits glucose uptake in the intestine and kidney: In vitro and in vivo studies.[Pubmed: 17038511 ]
    Rhubarb extracts have been reported to improve oral glucose tolerance in diabetic animals.
    METHODS AND RESULTS:
    In the present study we have investigated the antidiabetic actions of desoxyrhaponticin, a major stilbene in rhubarb, as a glucose uptake inhibitor. Desoxyrhaponticin was demonstrated to inhibit glucose uptake in rabbit intestinal membrane vesicles as well as in rat everted gut sleeves, with IC50 values of 148.3 and 30.9 microM, respectively. Kinetics studies revealed that desoxyrhaponticin is a competitive inhibitor of glucose uptake in both systems. Moreover, desoxyrhaponticin could reduce glucose uptake in the intestinal membrane vesicles of both normal and diabetic rats. In addition, glucose uptake in the renal membrane vesicles of both normal and diabetic rats was reduced by desoxyrhaponticin. Under the inhibition of desoxyrhaponticin, uptake of glucose in both the intestinal and renal membrane vesicles of the normal rats was no different from that of the diabetic rats. The IC50 values of the uptake inhibition in the renal membrane vesicles of normal and diabetic rats were 118.8 and 115.7 microM, respectively. In a type 2 diabetic animal model in which rats have been treated with streptozotocin at the neonatal stage, postprandial hyperglycemia was significantly suppressed by oral administration of this compound (300 mg/kg b.wt.).
    CONCLUSIONS:
    These results suggest that desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes. The in vivo antidiabetic action of this compound can be explained, in part at least, by inhibition of glucose transport in the small intestine and inhibition of glucose reabsorption in the kidney.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4728 mL 12.364 mL 24.728 mL 49.456 mL 61.82 mL
    5 mM 0.4946 mL 2.4728 mL 4.9456 mL 9.8912 mL 12.364 mL
    10 mM 0.2473 mL 1.2364 mL 2.4728 mL 4.9456 mL 6.182 mL
    50 mM 0.0495 mL 0.2473 mL 0.4946 mL 0.9891 mL 1.2364 mL
    100 mM 0.0247 mL 0.1236 mL 0.2473 mL 0.4946 mL 0.6182 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    土大黄苷 2''-O-没食子酸酯; Rhaponticin 2''-O-gallate CFN91100 94356-24-8 C28H28O13 = 572.51 5mg QQ客服:1457312923
    2,3,5,4-四羟基二苯乙烯葡萄糖苷; 2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside CFN99995 82373-94-2 C20H22O9 = 406.39 20mg QQ客服:3257982914
    松茋; Pinostilbene CFN98662 42438-89-1 C15H14O3 = 242.3 5mg QQ客服:3257982914
    1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6→1)-O-α-L-rhamnopyranosyl]phenylethane; 1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6->1)-O-alpha-L-rhamnopyranosyl]phenylethane CFN95285 1338076-61-1 C28H38O12 = 566.6 5mg QQ客服:2056216494
    Pinostilbenoside; Pinostilbenoside CFN98995 58762-96-2 C21H24O8 = 404.4 5mg QQ客服:2056216494
    3-羟基-5-甲氧基二苯乙烯; 5-Methoxy-3-stilbenol CFN92587 5150-38-9 C15H14O2 = 226.3 5mg QQ客服:2159513211
    Thunalbene; Thunalbene CFN92783 220862-05-5 C15H14O3 = 242.3 5mg QQ客服:3257982914
    3'-O-甲基山药素III; 3'-O-Methylbatatasin III CFN91176 101330-69-2 C16H18O3 = 258.3 10mg QQ客服:2159513211
    山药素 III; Batatasin III CFN92689 56684-87-8 C15H16O3 = 244.3 5mg QQ客服:1457312923
    山药素 IV; Batatasin IV CFN95319 60347-67-3 C15H16O3 = 244.3 5mg QQ客服:2159513211

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