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  • 窃衣素

    Torilin

    窃衣素
    产品编号 CFN96316
    CAS编号 13018-10-5
    分子式 = 分子量 C22H32O5 = 376.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The fruits of Torilis japonica.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    窃衣素 CFN96316 13018-10-5 1mg QQ客服:1413575084
    窃衣素 CFN96316 13018-10-5 5mg QQ客服:1413575084
    窃衣素 CFN96316 13018-10-5 10mg QQ客服:1413575084
    窃衣素 CFN96316 13018-10-5 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Macau University of Science and Technology (China)
  • University of Zurich (Switzerland)
  • University of Ioannina (Greece)
  • University of Illinois at Chicago (USA)
  • Monash University Malaysia (Malaysia)
  • Michigan State University (USA)
  • MTT Agrifood Research Finland (Finland)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Helmholtz Zentrum München (Germany)
  • Chang Gung University (Taiwan)
  • Kitasato University (Japan)
  • University of Melbourne (Australia)
  • Semmelweis Unicersity (Hungary)
  • University of Amsterdam (Netherlands)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Functional Foods2022, 96: 105216.
  • PLoS One.2021, 16(6):e0248479.
  • The Journal of Korean Medicine2022, 43(3): 79-93.
  • Natural Product Communications2020, doi: 10.1177.
  • Hum Exp Toxicol.2022, 41:9603271221143713.
  • Crystals2020, 10(3), 206.
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Agriculture2022, 12(12), 2173.
  • Molecules.2021, 26(12):3652.
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • Oxid Med Cell Longev.2021, 2021:4883398.
  • Phytomedicine.2022, 99:153997.
  • Sci Rep. 2017, 8207(7)
  • Oncol Rep.2019, 41(4):2453-2463
  • Research on Crops.2017, 18(2)
  • Nutrients.2021, 13(8):2901.
  • J Nat Med.2022, 76(1):59-67.
  • Nutrients2023, 15(18), 4016.
  • Sci Rep.2015, 5:13194
  • Journal of Functional Foods2021, 84:104581
  • Front Pharmacol.2019, 10:1355
  • J Ethnopharmacol.2016, 194:219-227
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • ...
  • 生物活性
    Description: Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but is weaker than finasteride (IC50 = 0.38 +/- 0.06 microM). Torilin has immunomodulatory, hepatoprotective, and anti-inflammatory properties, it inhibits inflammation by limiting TAK1-mediated MAP kinase and NF-κB activation, it can attenuate arthritis severity, modify leukocyte activations in dLNs or joints, and restore serum and splenocyte cytokine imbalances. Torilin inhibits melanin production in alpha-melanocyte stimulating hormone-activated B16 melanoma cells, with an IC(50) value of 25 microM. Torilin shows excellent antimicrobial activity against Bacillus subtilis ATCC 6633 spores and vegetative cells. Torilin has a potent anti-angiogenic activity both in vivo and in vitro, and it may have a strong activity to suppress tumorigenesis by inhibition of tumor invasion, it reverses multidrug-resistance in cancer cells, it can potentiate the cytotoxicities of adriamycin, vinblastine, taxol and colchicine against multidrug-resistant KB-V1 and MCF7/ADR cells.
    Targets: p38MAPK | JNK | ERK | AP-1 | p65 | NF-kB | IkB | Tyrosinase | MMP(e.g.TIMP) | 5-alpha reductase | IKK
    In vitro:
    Planta Med. 2009 Nov;75(14):1505-8.
    Torilin from Torilis japonica inhibits melanin production in alpha-melanocyte stimulating hormone-activated B16 melanoma cells.[Pubmed: 19533579 ]
    Epidermal melanocytes synthesize melanin pigments and transfer them to keratinocytes, which is responsible for skin pigmentation. However, abnormal accumulation of melanin pigments causes hyperpigmentation disorders, which are substantially improved with treatment of tyrosinase inhibitor. In our ongoing study, Torilis japonica DC. (Umbelliferae) was found to inhibit melanin production. A goal of this study is to elucidate the hypopigmenting principle of T. japonica.
    METHODS AND RESULTS:
    A sesquiterpene structure of torilin was isolated from the plant extracts via bioassay-guided phytochemical analysis. Torilin dose-dependently inhibited melanin production, with an IC(50) value of 25 microM, in alpha-melanocyte stimulating hormone (alpha-MSH)-activated B16 melanoma cells. Arbutin, a positive control of skin whitener, also inhibited alpha-MSH-induced melanin production with an IC(50) value of 170 microM. As to the mode of action, torilin downregulated alpha-MSH-induced protein levels of tyrosinase without directly inhibiting catalytic activity of the enzyme.
    CONCLUSIONS:
    Taken together, this study shows that torilin contributes to the hypopigmenting principle of T. japonica, and suggests its pharmacological potential in melanin-associated hyperpigmentation disorders.
    J Food Sci. 2008 Mar;73(2):M37-46.
    Antimicrobial activity of torilin isolated from Torilis japonica fruit against Bacillus subtilis.[Pubmed: 18298734 ]
    Torilis japonica fruit has been used in therapeutic antimicrobial treatments in Korea and China since ancient times, but there is still little information on the mechanism underlying this activity.
    METHODS AND RESULTS:
    We found that the ethanol extract of T. japonica fruit showed excellent antimicrobial activity against Bacillus subtilis ATCC 6633 spores and vegetative cells. The crude ethanol extract (75%) reduced the spore concentration by 3 log cycles and the vegetative cell concentration to lower than the detection level (reduction in spore concentration by more than 6 orders of magnitude) at a concentration of 1% (w/v). The ethanol extract of T. japonica fruit was fractionated into n-hexane (H) and a water layer. The active antimicrobial compound was isolated and purified from the hexane layer, and identified as torilin (5-[1-(acetyloxy)-1-methylethyl]-3,8-dimethyl-2-oxo-1,2,4,5,6,7,8,8a-octa-hydroazulen-6-yl(2E)-2-methylbut-2-enoate; C(22)H(32)O(5)). Torilin immediately reduced vegetative cells counts by 5 to 6 orders of magnitude, and reduced spores counts by 1 order of magnitude. The integrity of structures such as the inner, middle, and outer layers of the coat and the cortex, protoplast membrane, and core are vital to spores.
    CONCLUSIONS:
    Torilin functions as a surfactant with hydrophilic and hydrophobic properties related to denaturalization of various proteins. The distortion of coat proteins due to direct binding polar groups of spore coats with hydrophilic groups of torilin may be responsible for the observed rapid inactivation of bacterial spores.
    Planta Med. 2002 Aug;68(8):748-9.
    Sesquiterpenes with hepatoprotective activity from Cnidium monnieri on tacrine-induced cytotoxicity in Hep G2 cells.[Pubmed: 12221602 ]

    METHODS AND RESULTS:
    Bioassay-guided fractionation of the EtOH extract of Cnidium monnieri (Apiaceae) furnished two hepatoprotective sesquiterpenes, Torilin (1) and torilolone (2), together with a new derivative, 1-hydroxyTorilin (3).
    CONCLUSIONS:
    Compounds 1 and 2 showed hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. The EC50 values of compounds 1 and 2 were 20.6 +/- 1.86 (P < 0.01) and 3.6 +/- 0.1 (P < 0.01) microM, respectively. Silybin as a positive control showed an EC50 value of 69.0 +/- 3.4 microM.
    In vivo:
    Int Immunopharmacol. 2013 Jun;16(2):232-42.
    Torilin ameliorates type II collagen-induced arthritis in mouse model of rheumatoid arthritis.[Pubmed: 23623942 ]
    Advancements in rheumatoid-arthritis-(RA) therapies have shown considerable progresses in the comprehension of disease. However, the development of new potential agents with relative safety and efficacy continues and natural compounds have been considered as alternatives to identify new entities.
    METHODS AND RESULTS:
    Since previous in-vivo data and our in-vitro findings showed that torilin has a strong anti-inflammatory property, we further investigated its effect against collagen-induced-arthritis-(CIA) in mice. CIA-induced DBA/1J mice were treated with torilin or methotrexate (MTX) for 5-weeks. Arthritis severity was evaluated by arthritic score and joint histopathology. Draining lymph node (dLN), joint and peripheral-blood mononuclear-cell (PBMC) counts, and activation/localization of T-/B-lymphocytes, dendritic cells (DCs) and neutrophils were examined by FACS analysis. Serum anti-type-II-collagen-(CII) antibody levels and cultured-splenocyte and serum cytokines were also evaluated. Torilin markedly reduced CIA-induced arthritic score, histopathology and leukocyte counts. Besides, torilin suppressed CIA-activated T-cells including CD3+, CD3+/CD69+, CD8+, CD4+ and CD4+/CD25+ in dLNs or joints. It also modified CD19+ or CD20+/CD23+ (B-cells), MHCII+/CD11c+ (DCs) and Gr-1+/CD11b+ (neutrophil) subpopulations. It further depressed total anti-CII-IgG, anti-CII-IgG1 and anti-CII-IgG2a antibody productions. Moreover, while IFN-γ and IL-10 were not affected, torilin suppressed CIA-induced serum TNF-α, IL-1β and IL-6 levels. Interestingly, torilin also blocked IFN-γ, IL-17 and IL-6 cytokines while it did not affect IL-10 but enhanced IL-4 in splenocytes.
    CONCLUSIONS:
    These results show that torilin attenuated arthritis severity, modified leukocyte activations in dLNs or joints, and restored serum and splenocyte cytokine imbalances. Torilin may have immunomodulatory and anti-inflammatory properties with the capacity to ameliorate the inflammatory response in CIA-mice.
    Oncol Rep. 2001 Mar-Apr;8(2):359-64.
    Anti-invasive activity of torilin, a sesquiterpene compound isolated from Torilis japonica.[Pubmed: 11182056]
    Torilin is a sesquiterpene compound purified from Torilis japonica (Umbelliferae). We have previously reported that torilin has a potent anti-angiogenic activity both in vivo and in vitro.
    METHODS AND RESULTS:
    In the present study, we investigated the anti-invasive activity of torilin, and interestingly found that torilin completely blocked intravasation of HT1080 human fibrosarcoma cells inoculated on the chorioallantoic membrane (CAM) of chick embryo. In addition, torilin decreased the attachment of HT1080 cells to confluent human umbilical vein endothelial cells (HUVECs) at non-toxic concentration. In in vitro transwell invasion model, 25 microM torilin also significantly inhibited HT1080 cell invasion in a time-dependent manner. Activity and expression of matrix metalloproteinase-9 (MMP-9) that is very important in tumor invasion and metastasis were also decreased by torilin treatment, indicating that the inhibitory effect of torilin on invasion of HT1080 cells may result from decreasing activity and expression of MMP-9.
    CONCLUSIONS:
    Therefore, it is possible that torilin may decrease metastatic potential of tumor cells through inhibiting their attachment to endothelial cells and intravasation to blood vessels. Taken together, torilin may have a strong activity to suppress tumorigenesis by inhibition of tumor invasion.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.656 mL 13.2802 mL 26.5604 mL 53.1208 mL 66.4011 mL
    5 mM 0.5312 mL 2.656 mL 5.3121 mL 10.6242 mL 13.2802 mL
    10 mM 0.2656 mL 1.328 mL 2.656 mL 5.3121 mL 6.6401 mL
    50 mM 0.0531 mL 0.2656 mL 0.5312 mL 1.0624 mL 1.328 mL
    100 mM 0.0266 mL 0.1328 mL 0.2656 mL 0.5312 mL 0.664 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    表莪述烯醇; Epiprocurcumenol CFN91614 127214-97-5 C15H22O2 = 234.33 5mg QQ客服:215959384
    Aerugidiol; Aerugidiol CFN92621 116425-35-5 C15H22O3 = 250.3 5mg QQ客服:2056216494
    新原莪述烯醇; Neoprocurcumenol CFN92789 102130-91-6 C15H22O2 = 234.3 5mg QQ客服:2056216494
    窃衣醇酮; Torilolone CFN96368 13018-09-2 C15H24O3 = 252.4 5mg QQ客服:1457312923
    8-O-乙酰窃衣醇酮; 8-O-Acetyltorilolone CFN96792 20482-21-7 C17H26O4 = 294.39 5mg QQ客服:1457312923
    窃衣素; Torilin CFN96316 13018-10-5 C22H32O5 = 376.5 5mg QQ客服:1413575084
    1alpha-羟基窃衣素; 1alpha-Hydroxytorilin CFN96357 887147-75-3 C22H32O6 = 392.5 5mg QQ客服:1457312923
    1beta-羟基窃衣素; 1beta-Hydroxytorilin CFN96793 509078-16-4 C22H32O6 = 392.49 5mg QQ客服:2159513211
    苏葛三醇 6,9-二乙酸酯; Sugetriol 6,9-diacetate CFN96652 17928-63-1 C19H28O5 = 336.43 5mg QQ客服:1413575084
    莪术醇; Curcumenol CFN92614 19431-84-6 C15H22O2 = 234.3 20mg QQ客服:2056216494

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