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  • 紫杉奇芬

    Taxagifine

    紫杉奇芬
    产品编号 CFN96641
    CAS编号 81489-69-2
    分子式 = 分子量 C37H44O13 = 696.74
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The needles and twigs of Taxus cuspidata.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    紫杉奇芬 CFN96641 81489-69-2 1mg QQ客服:3257982914
    紫杉奇芬 CFN96641 81489-69-2 5mg QQ客服:3257982914
    紫杉奇芬 CFN96641 81489-69-2 10mg QQ客服:3257982914
    紫杉奇芬 CFN96641 81489-69-2 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Utah State University (USA)
  • Subang Jaya Medical Centre (Malaysia)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • University of Malaya (Malaysia)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Melbourne (Australia)
  • Kyushu University (Japan)
  • University of Toulouse (France)
  • Celltrion Chemical Research Institute (Korea)
  • Uniwersytet Gdański (Poland)
  • University of British Columbia (Canada)
  • Copenhagen University (Denmark)
  • The Institute of Cancer Research (United Kingdom)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Plant Methods.2017, 13:108
  • J.Food Processing & Preservation2022, jfpp.16666
  • J of Advanced Scientific R.2020, 11(3), p109-120.
  • J Adv Res.2019, 17:85-94
  • World J Mens Health.2019, 10.5534
  • Food Chem.2020, 332:127412
  • Nutrients.2017, 10(1)
  • Eur Endod J.2020, 5(1):23-27.
  • Trop J Pharm Res.2023, 22(3):283-288.
  • Front Aging Neurosci.2019, 11:230
  • Phytomedicine2022, 104:154318
  • Bioengineering2023, 10(10), 1113.
  • Food Sci Nutr.2019, 8(1):246-256
  • Pharmaceutical Chemistry Journal2019, 52(12):986-991
  • Food Bioscience2023, 56:103311.
  • Pharmacol Rep.2020, 72(2):472-480.
  • bioRxiv2021, 458409.
  • Phytomedicine.2018, 40:37-47
  • Res Rep Urol.2022, 14:313-326.
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Food Chem.2017, 221:1135-1144
  • Int J Mol Sci.2021, 22(19):10405.
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • ...
  • 生物活性
    Description: Taxagifine shows cytotoxic activity toward HepG2 cells; it can suppress the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner.
    In vitro:
    Journal of Wood Science, 2008, 54(5):390-401.
    The polar neutral and basic taxoids isolated from needles and twigs of Taxus cuspidata and their biological activity[Reference: WebLink]

    METHODS AND RESULTS:
    Twelve basic taxoids and 22 neutral taxoids were isolated from basic and polar neutral fractions of the extracts of needles and twigs of Taxus cuspidata. Among them, taxine NA-13, 3,11-cyclotaxinine NN-1, taxinine NN-6, 11(15[rightward arrow]1)abeo-taxinine NN-1, taxine NA-8, and taxine NA-4 were isolated first from natural sources by us. The cytotoxic activity of isolated compounds was evaluated against three human cell lines: normal human fibroblast cells (WI-38), malignant tumor cells induced from WI-38 (VA-13), and human liver tumor cells (HepG2).
    CONCLUSIONS:
    7-Epitaxol, 7-epicephalomannine, taxinine NN-6, taxine NA-2, taxuspine H, and Taxagifine were active toward VA-13 cells and 7-epitaxol, 7-epicephalomannine, taxinine NN-1, 9,10-deacetyltaxinine, and Taxagifine were active toward HepG2 cells.
    In vivo:
    Planta Med. 2009 Jun;75(8):814-22.
    Effect of seven tricyclic diterpenoids from needles of Taxus media var. Hicksii on stimulus-induced superoxide generation, tyrosyl or serine/threonine phosphorylation and translocation of cytosolic compounds to the cell membrane in human neutrophils.[Pubmed: 19288401 ]
    Taxol has been widely used as an anticancer drug for ovarian, breast, lung and prostate cancer. Some kinds of Taxus plants are widely distributed in the Northeast Asia region.
    METHODS AND RESULTS:
    We have isolated seven tricyclic diterpenoids, taxinine, taxagifine, 5-O-cinnamoyltaxacin I triacetate, 5-decinnamoyltaxinine J, 5-cinnamoyl-9-acetyltaxicin I, taxacin and taxol from the needles of Taxus media var. Hicksii, and investigated their effects on stimulus-induced superoxide generation and translocation of cytosolic compounds to the cell membrane in human neutrophils. Six tricyclic diterpenoids used in this experiment suppressed the superoxide generation induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP) and arachidonic acid (AA) in a concentration-dependent manner. Taxinine significantly suppressed the superoxide generation induced by phorbol 12-myristate 13-acetate (PMA).
    CONCLUSIONS:
    The compounds also suppressed fMLP- and AA-induced tyrosyl or PMA-induced serine/threonine phosphorylation, and translocation of cytosolic compounds, p47 (phox), p67 (phox) and Rac to the cell membrane in parallel with the suppression of the stimulus-induced superoxide generation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4353 mL 7.1763 mL 14.3526 mL 28.7051 mL 35.8814 mL
    5 mM 0.2871 mL 1.4353 mL 2.8705 mL 5.741 mL 7.1763 mL
    10 mM 0.1435 mL 0.7176 mL 1.4353 mL 2.8705 mL 3.5881 mL
    50 mM 0.0287 mL 0.1435 mL 0.2871 mL 0.5741 mL 0.7176 mL
    100 mM 0.0144 mL 0.0718 mL 0.1435 mL 0.2871 mL 0.3588 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7beta-Acetoxytaxuspine C ; 7beta-Acetoxytaxuspine C CFN96914 256347-91-8 C37H44O11 = 664.74 5mg QQ客服:3257982914
    Taxezopidine G; Taxezopidine G CFN96639 205440-22-8 C35H44O9 = 608.72 5mg QQ客服:1413575084
    7-去乙酰氧紫杉宁J; 7-Deacetoxytaxinine J CFN89400 18457-45-9 C37H46O10 = 650.75 5mg QQ客服:1457312923
    Taxezopidine H; Taxezopidine H CFN95562 205440-23-9 C35H44O9 = 608.7 5mg QQ客服:2056216494
    2-去乙酰氧紫杉宁J; 2-Deacetoxytaxinine J CFN96989 119347-14-7 C37H46O10 = 650.76 10mg QQ客服:2056216494
    2,7-二去乙酰氧紫杉宁J; 2,7-Dideacetoxytaxinine J CFN96979 115810-14-5 C35H44O8 = 592.72 5mg QQ客服:2056216494
    9-Deacetyltaxinine E ; 9-Deacetyltaxinine E CFN96923 284672-78-2 C35H44O9 = 608.72 5mg QQ客服:1457312923
    紫杉宁; Taxinine CFN96636 3835-52-7 C35H42O9 = 606.71 5mg QQ客服:215959384
    紫杉宁 J ; Taxinine J CFN96635 18457-46-0 C39H48O12 = 708.80 5mg QQ客服:3257982914
    紫杉宁 M; Taxinine M CFN96634 135730-55-1 C35H42O14 = 686.70 5mg QQ客服:2159513211

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