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  • 2-去乙酰氧紫杉宁J

    2-Deacetoxytaxinine J

    2-去乙酰氧紫杉宁J
    产品编号 CFN96989
    CAS编号 119347-14-7
    分子式 = 分子量 C37H46O10 = 650.76
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The heartwoods of Taxus cuspidata.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2-去乙酰氧紫杉宁J CFN96989 119347-14-7 1mg QQ客服:1413575084
    2-去乙酰氧紫杉宁J CFN96989 119347-14-7 5mg QQ客服:1413575084
    2-去乙酰氧紫杉宁J CFN96989 119347-14-7 10mg QQ客服:1413575084
    2-去乙酰氧紫杉宁J CFN96989 119347-14-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biosci Biotechnol Biochem.2021, 85(10):2153-2160.
  • Applied Biological Chemistry2022, 65(77).
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  • Institute of Food Science & Technology2021, 45(9).
  • J Ethnopharmacol.2019, 228:132-141
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  • Korean J. Crop Sci.2018, 63(2):131-139
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  • Int J Mol Sci.2020, 21(9):3239.
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  • Tropical Journal of Pharmaceutical Research 2021, 20(6):1165-1170.
  • LWT2021, 138:110630.
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  • Evid Based Complement Alternat Med.2018, 2018:3610494
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  • ...
  • 生物活性
    Description: 2-Deacetoxytaxinine J shows significant in vitro activity against breast cancer cell line at a concentration of 20 microM and 10 microM in MCF-7 and MDA-MB-231 respectively.
    In vitro:
    Eur J Med Chem. 2009 Oct;44(10):3947-53.
    In vitro and in vivo anticancer activity of 2-deacetoxytaxinine J and synthesis of novel taxoids and their in vitro anticancer activity.[Pubmed: 19446930]

    METHODS AND RESULTS:
    The taxane diterpneoid 2-Deacetoxytaxinine J (2-DAT-J) 1 has been isolated from the bark of Himalayan yew, Taxus baccata L. spp. wallichiana in a reasonably good yield (0.1%) and its anticancer activity against breast cancer cell lines (MCF-7 and MDA-MB-231) and normal human kidney epithelial cell line (HEK-293) has been studied. 2-DAT-J (1) showed significant in vitro activity against breast cancer cell line at a concentration of 20 microM and 10 microM in MCF-7 and MDA-MB-231 respectively. Few novel taxoids were derived (7, 8 and 10-13) from the naturally occurring 2-DAT-J (1) and screened for their anticancer activity.
    CONCLUSIONS:
    The structure-activity relationship studies indicated that the cinnamoyl group on C-5 and acetyl group on C-10 are essential for the anticancer activity. 2-DAT-J (1) was also tested for its in vivo activity on DMBA-induced mammary tumors in virgin female Sprague Dawley rats at a dose of 10mg/kg body weight orally for 30 days and showed significant regression in mammary tumors as compared to vehicle treated group (p<0.05).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5367 mL 7.6833 mL 15.3666 mL 30.7333 mL 38.4166 mL
    5 mM 0.3073 mL 1.5367 mL 3.0733 mL 6.1467 mL 7.6833 mL
    10 mM 0.1537 mL 0.7683 mL 1.5367 mL 3.0733 mL 3.8417 mL
    50 mM 0.0307 mL 0.1537 mL 0.3073 mL 0.6147 mL 0.7683 mL
    100 mM 0.0154 mL 0.0768 mL 0.1537 mL 0.3073 mL 0.3842 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Taxezopidine L; Taxezopidine L CFN96638 219749-76-5 C39H46O15 = 754.78 5mg QQ客服:2056216494
    东北红豆杉素; Taxacin CFN96642 117229-54-6 C44H48O15 = 816.85 5mg QQ客服:2056216494
    1-羟基浆果赤霉素I; 1-Hydroxybaccatin I CFN98378 30244-37-2 C32H44O14 = 652.7 5mg QQ客服:2056216494
    Taxumairol B; Taxumairol B CFN96632 142203-64-3 C28H40O12 = 568.61 5mg QQ客服:3257982914
    云南红豆杉甲素; Yunnanxane CFN96412 139713-81-8 C31H46O9 = 562.6 5mg QQ客服:3257982914
    10-Deacetylyunnanxane; 10-Deacetylyunnanxane CFN89037 1333323-17-3 C29H44O8 = 520.66 5mg QQ客服:3257982914
    2-去乙酰氧-5α-羟基紫杉宁J ; 2-Deacetoxydecinnamoyltaxinine J CFN96913 87193-98-4 C28H40O9 = 520.61 5mg QQ客服:3257982914
    Decinnamoyltaxinine J ; Decinnamoyltaxinine J CFN96905 84652-33-5 C30H42O11 = 578.65 5mg QQ客服:1413575084
    2-去乙酰氧基紫杉素B; 2-Deacetoxytaxinine B CFN99887 191547-12-3 C35H42O9 = 606.7 5mg QQ客服:3257982914
    紫杉素B; Taxinine B CFN99855 18457-44-8 C37H44O11 = 664.8 5mg QQ客服:3257982914

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