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  • 牛磺胆酸

    Taurocholic acid

    牛磺胆酸
    产品编号 CFN96646
    CAS编号 81-24-3
    分子式 = 分子量 C26H45NO7S = 515.70
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 From snake bile.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    牛磺胆酸 CFN96646 81-24-3 1mg QQ客服:215959384
    牛磺胆酸 CFN96646 81-24-3 5mg QQ客服:215959384
    牛磺胆酸 CFN96646 81-24-3 10mg QQ客服:215959384
    牛磺胆酸 CFN96646 81-24-3 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Pennsylvania State University (USA)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • University of Eastern Finland (Finland)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • University of Sao Paulo (Brazil)
  • Universitas Airlangga (Indonesia)
  • Lodz University of Technology (Poland)
  • Seoul National University of Science and Technology (Korea)
  • Chinese University of Hong Kong (China)
  • University of British Columbia (Canada)
  • Gyeongsang National University (Korea)
  • University of Zurich (Switzerland)
  • Kyushu University (Japan)
  • Agricultural Research Organization (ARO) (Israel)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Malaysian Journal of Analytical Sciences2022, 26(2):360-369.
  • J Inflamm Res.2022, 15:5347-5359.
  • Plants (Basel).2021, 10(12):2795.
  • Plant Physiol Biochem.2021, 160:166-174.
  • Mie University2019, 10076.
  • Metabolites.2019, 9(11):E271
  • J Agric Food Chem.2022, 70(51):16176-16187.
  • Int J Oncol.2019, 55(1):320-330
  • Nutrients.2019, 12(1)
  • Nutrients.2019, 12(1):E40
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Adaptive Medicine 2020, 12(1): 4-10
  • Industrial Crops and Products2019, 140:111612
  • Molecules.2019, 24(4):E744
  • mBio.2020, 11(3):e00686-20.
  • Separations2023, 10(11), 567;
  • Phytomedicine.2019, 65:153089
  • University of Central Lancashire2017, 20472
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • J Chromatogr A.2022, 1685:463640.
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Phytother Res.2019, 33(5):1490-1500
  • Current Pharmaceutical Analysis2017, 13(5)
  • ...
  • 生物活性
    Description: Taurocholic acid feeding shows cytoprotective effects on the biliary tree after adrenergic denervation of the liver; taurocholic acid feeding prevents tumor necrosis factor-alpha-induced damage of cholangiocytes by a PI3K-mediated pathway. Rectal administration of taurocholic acid can stimulate glucagon-like peptide-1 and peptide YY by TGR5 receptor activation, which may have potential for the management of type 2 diabetes and obesity.
    Targets: TNF-α | PI3K | Akt | p38MAPK | Caspase | TGR5
    In vivo:
    Diabetes Obes Metab. 2013 May;15(5):474-7.
    Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans.[Pubmed: 23181598 ]
    Glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), secreted by enteroendocrine L-cells located most densely in the colon and rectum, are of fundamental importance in blood glucose and appetite regulation. In animal models, colonic administration of bile acids can stimulate GLP-1 and PYY by TGR5 receptor activation.
    METHODS AND RESULTS:
    We evaluated the effects of taurocholic acid (TCA), administered as an enema, on plasma GLP-1 and PYY, as well as gastrointestinal sensations in 10 healthy male subjects, and observed that rectal administration of TCA promptly stimulated secretion of both GLP-1 and PYY, and increased fullness, in a dose-dependent manner.
    CONCLUSIONS:
    These observations confirm that topical application of bile acids to the distal gut may have potential for the management of type 2 diabetes and obesity.
    Liver Int. 2007 May;27(4):558-68.
    Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver.[Pubmed: 17403196 ]
    Cholangiopathies impair the balance between proliferation and apoptosis of cholangiocytes leading to the disappearance of bile ducts and liver failure. Taurocholic acid (TC) is essential for cholangiocyte proliferative and functional response to cholestasis. Bile acids and neurotransmitters co-operatively regulate the biological response of the biliary epithelium to cholestasis. Adrenergic denervation of the liver during cholestasis results in the damage of bile ducts. To verify whether TC feeding prevents the damage of the biliary tree induced by adrenergic denervation in the course of cholestasis.
    METHODS AND RESULTS:
    Rats subjected to bile duct ligation (BDL) and to adrenergic denervation were fed a TC-enriched diet, in the absence or presence of daily administration of the phosphatidyl-inositol-3-kinase (PI3K) inhibitor wortmannin for 1 week. TC prevented the induction of cholangiocyte apoptosis induced by adrenergic denervation. TC also restored cholangiocyte proliferation and functional activity, reduced after adrenergic denervation. TC prevented AKT dephosphorylation induced by adrenergic denervation. The cytoprotective effects of TC were abolished by the simultaneous administration of wortmannin.
    CONCLUSIONS:
    TC administration prevents the damage of the biliary tree induced by the adrenergic denervation of the liver. These novel findings open novel perspectives in the understanding of the potential of bile acids especially in post-transplant liver disease.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9391 mL 9.6956 mL 19.3911 mL 38.7822 mL 48.4778 mL
    5 mM 0.3878 mL 1.9391 mL 3.8782 mL 7.7564 mL 9.6956 mL
    10 mM 0.1939 mL 0.9696 mL 1.9391 mL 3.8782 mL 4.8478 mL
    50 mM 0.0388 mL 0.1939 mL 0.3878 mL 0.7756 mL 0.9696 mL
    100 mM 0.0194 mL 0.097 mL 0.1939 mL 0.3878 mL 0.4848 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    牛磺胆酸; Taurocholic acid CFN96646 81-24-3 C26H45NO7S = 515.70 5mg QQ客服:3257982914
    牛磺熊去氧胆酸 ; Tauroursodeoxycholic acid CFN96645 14605-22-2 C26H45NO6S = 499.70 5mg QQ客服:2056216494
    牛磺鹅去氧胆酸钠; Sodium taurochenodeoxycholate CFN80241 6009-98-9 C26H44NNaO6S = 521.68 5mg QQ客服:1413575084
    熊去氧胆酸; Ursodeoxycholic acid CFN96464 128-13-2 C24H40O4 = 392.58 20mg QQ客服:1413575084
    鹅去氧胆酸; 鹅脱氧胆酸; Chenodeoxycholic acid CFN90478 474-25-9 C24H40O4 = 392.57 20mg QQ客服:2159513211
    胆酸; Cholic acid CFN99796 81-25-4 C22H40O5 = 408.57 20mg QQ客服:215959384
    猪胆酸; Hyocholic acid CFN91626 547-75-1 C24H40O5 = 408.6 5mg QQ客服:2056216494
    去氧胆酸; Deoxycholic acid CFN99798 83-44-3 C24H40O4 = 392.57 20mg QQ客服:215959384
    石胆酸; Lithocholic acid CFN89170 434-13-9 C24H40O3 = 376.58 20mg QQ客服:215959384
    胆酸钠; Sodium cholate CFN96673 361-09-1 C24H39NaO5 = 430.55 5mg QQ客服:1457312923

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