甘氨脱氧胆酸

Glycodeoxycholic acid

	产品编号	CFN96947
	CAS编号	360-65-6
	分子式 = 分子量	C₂₆H₄₃NO₅ = 449.63
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源	The derivatives of deoxycholic acid and glycine.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
甘氨脱氧胆酸	CFN96947	360-65-6	10mg	QQ客服：215959384
甘氨脱氧胆酸	CFN96947	360-65-6	20mg	QQ客服：215959384
甘氨脱氧胆酸	CFN96947	360-65-6	50mg	QQ客服：215959384
甘氨脱氧胆酸	CFN96947	360-65-6	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Glycodeoxycholic acid levels could as prognostic biomarker in acetaminophen-induced acute liver failure patients. Glycodeoxycholic acid can induce the apoptosis of SMMC-7721 cells.

Targets:

p53

In vitro:

Chinese Journal of Clinical Laboratory Science, 2009, 27(3):167-169.

The effect of glycodeoxycholic acid on P53 expression in the apoptosis of SMMC-7721 cells[Reference: WebLink]

To investigate the effect of Glycodeoxycholic acid(GDCA) on apoptosis of and P53 expression in SMMC-7721 cells.
METHODS AND RESULTS:
Apoptotic rate was examined by Annexin V.P53 mRNA was analyzed by RT-PCR,and P53 protein was measured by immunohistochemistry technique.Compared with the control,SMMC-7721 cells treated with GDCA had significantly increased apoptotic rate in a dose-and time-dependent manner.After treated with 200 μmol/L GDCA,the apoptotic rates of the cells at 48 h and 72 h were(7.67±2.35)% and(12.93±1.48)% respectively.When the GDCA concentration was raised to 400 μmol/L,the apoptotic rates of the cells at 48 h and 72 h also increased to(13.14±2.56)% and(14.22±2.11)% respectively.The p53 mRNA in SMMC-7721 cells was up-regulated,whereas the mutant P53 protein was obviously inhibited after the cells were treated with GDCA.
CONCLUSIONS:
GDCA can induce the apoptosis of SMMC-7721 cells.

In vivo:

Toxicol Sci. 2014 Dec; 142(2): 436–444.

Glycodeoxycholic Acid Levels as Prognostic Biomarker in Acetaminophen-Induced Acute Liver Failure Patients[Pubmed: 25239633]

Acetaminophen (APAP)-induced acute liver failure (ALF) remains a major clinical problem. Although a majority of patients recovers after severe liver injury, a subpopulation of patients proceeds to ALF. Bile acids are generated in the liver and accumulate in blood during liver injury, and as such, have been proposed as biomarkers for liver injury and dysfunction. The goal of this study was to determine whether individual bile acid levels could determine outcome in patients with APAP-induced ALF (AALF).
METHODS AND RESULTS:
Serum bile acid levels were measured in AALF patients using mass spectrometry. Bile acid levels were elevated 5–80-fold above control values in injured patients on day 1 after the overdose and decreased over the course of hospital stay. Interestingly, Glycodeoxycholic acid (GDCA) was significantly increased in non-surviving AALF patients compared with survivors. GDCA values obtained at peak alanine aminotransferase (ALT) and from day 1 of admission indicated GDCA could predict survival in these patients by receiver-operating characteristic analysis (AUC = 0.70 for day 1, AUC = 0.68 for peak ALT). Of note, AALF patients also had significantly higher levels of serum bile acids than patients with active cholestatic liver injury.
CONCLUSIONS:
These data suggest measurements of GDCA in this patient cohort modestly predicted outcome and may serve as a prognostic biomarker. Furthermore, accumulation of bile acids in serum or plasma may be a result of liver cell dysfunction and not cholestasis, suggesting elevation of circulating bile acid levels may be a consequence and not a cause of liver injury.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
胆酸; Cholic acid	CFN99796	81-25-4	C₂₂H₄₀O₅ = 408.57	20mg	QQ客服：1413575084
猪胆酸; Hyocholic acid	CFN91626	547-75-1	C₂₄H₄₀O₅ = 408.6	5mg	QQ客服：2056216494
去氧胆酸; Deoxycholic acid	CFN99798	83-44-3	C₂₄H₄₀O₄ = 392.57	20mg	QQ客服：215959384
石胆酸; Lithocholic acid	CFN89170	434-13-9	C₂₄H₄₀O₃ = 376.58	20mg	QQ客服：215959384
胆酸钠; Sodium cholate	CFN96673	361-09-1	C₂₄H₃₉NaO₅ = 430.55	5mg	QQ客服：1457312923
甘氨脱氧胆酸; Glycodeoxycholic acid	CFN96947	360-65-6	C₂₆H₄₃NO₅ = 449.63	20mg	QQ客服：1413575084
甘氨熊去氧胆酸; Glycoursodeoxycholic acid	CFN89075	64480-66-6	C₂₆H₄₃NO₅ = 449.63	20mg	QQ客服：215959384
牛磺胆酸; Taurocholic acid	CFN96646	81-24-3	C₂₆H₄₅NO₇S = 515.70	5mg	QQ客服：2056216494
牛磺熊去氧胆酸 ; Tauroursodeoxycholic acid	CFN96645	14605-22-2	C₂₆H₄₅NO₆S = 499.70	5mg	QQ客服：215959384
牛磺鹅去氧胆酸钠; Sodium taurochenodeoxycholate	CFN80241	6009-98-9	C₂₆H₄₄NNaO₆S = 521.68	5mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2241 mL	11.1203 mL	22.2405 mL	44.481 mL	55.6013 mL
5 mM	0.4448 mL	2.2241 mL	4.4481 mL	8.8962 mL	11.1203 mL
10 mM	0.2224 mL	1.112 mL	2.2241 mL	4.4481 mL	5.5601 mL
50 mM	0.0445 mL	0.2224 mL	0.4448 mL	0.8896 mL	1.112 mL
100 mM	0.0222 mL	0.1112 mL	0.2224 mL	0.4448 mL	0.556 mL

甘氨脱氧胆酸

Glycodeoxycholic acid

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