牛磺鹅去氧胆酸钠

Sodium taurochenodeoxycholate

	产品编号	CFN80241
	CAS编号	6009-98-9
	分子式 = 分子量	C₂₆H₄₄NNaO₆S = 521.68
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源	From bear biliary.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
牛磺鹅去氧胆酸钠	CFN80241	6009-98-9	1mg	QQ客服：215959384
牛磺鹅去氧胆酸钠	CFN80241	6009-98-9	5mg	QQ客服：215959384
牛磺鹅去氧胆酸钠	CFN80241	6009-98-9	10mg	QQ客服：215959384
牛磺鹅去氧胆酸钠	CFN80241	6009-98-9	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Queensland (Australia)

Osmania University (India)

Aveiro University (Portugal)

University of Liège (Belgium)

University of Auckland (New Zealand)

Indian Institute of Science (India)

Istanbul University (Turkey)

Universidade de Franca (Brazil)

Mahatma Gandhi University (India)

CSIRO - Agriculture Flagship (Australia)

St. Jude Children Research Hospital (USA)

Uniwersytet Gdański (Poland)

National Research Council of Canada (Canada)

University of Zurich (Switzerland)

More...

Description:

Sodium taurochenodeoxycholate can increase glucose-induced insulin secretion and stimulate the electrical activity of β-cells and enhance cytosolic Ca(2+) concentration ([Ca(2+)](c)).

Targets:

ATPase | Potassium Channel | Calcium Channel

In vitro:

Diabetes. 2012 Jun;61(6):1479-89.

Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition.[Pubmed: 22492528 ]

Type 2 diabetes mellitus is associated with alterations in bile acid (BA) signaling. The aim of our study was to test whether pancreatic β-cells contribute to BA-dependent regulation of glucose homeostasis.
METHODS AND RESULTS:
Experiments were performed with islets from wild-type, farnesoid X receptor (FXR) knockout (KO), and β-cell ATP-dependent K(+) (K(ATP)) channel gene SUR1 (ABCC8) KO mice, respectively. Sodium taurochenodeoxycholate (TCDC) increased glucose-induced insulin secretion. This effect was mimicked by the FXR agonist GW4064 and suppressed by the FXR antagonist guggulsterone. TCDC and GW4064 stimulated the electrical activity of β-cells and enhanced cytosolic Ca(2+) concentration ([Ca(2+)](c)). These effects were blunted by guggulsterone. Sodium ursodeoxycholate, which has a much lower affinity to FXR than TCDC, had no effect on [Ca(2+)](c) and insulin secretion. FXR activation by TCDC is suggested to inhibit K(ATP) current. The decline in K(ATP) channel activity by TCDC was only observed in β-cells with intact metabolism and was reversed by guggulsterone. TCDC did not alter insulin secretion in islets of SUR1-KO or FXR-KO mice. TCDC did not change islet cell apoptosis.
CONCLUSIONS:
This is the first study showing an acute action of BA on β-cell function. The effect is mediated by FXR by nongenomic elements, suggesting a novel link between FXR activation and K(ATP) channel inhibition.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
熊去氧胆酸; Ursodeoxycholic acid	CFN96464	128-13-2	C₂₄H₄₀O₄ = 392.58	20mg	QQ客服：2159513211
鹅去氧胆酸；鹅脱氧胆酸; Chenodeoxycholic acid	CFN90478	474-25-9	C₂₄H₄₀O₄ = 392.57	20mg	QQ客服：215959384
胆酸; Cholic acid	CFN99796	81-25-4	C₂₂H₄₀O₅ = 408.57	20mg	QQ客服：215959384
猪胆酸; Hyocholic acid	CFN91626	547-75-1	C₂₄H₄₀O₅ = 408.6	5mg	QQ客服：2159513211
去氧胆酸; Deoxycholic acid	CFN99798	83-44-3	C₂₄H₄₀O₄ = 392.57	20mg	QQ客服：2056216494
石胆酸; Lithocholic acid	CFN89170	434-13-9	C₂₄H₄₀O₃ = 376.58	20mg	QQ客服：1413575084
胆酸钠; Sodium cholate	CFN96673	361-09-1	C₂₄H₃₉NaO₅ = 430.55	5mg	QQ客服：215959384
甘氨脱氧胆酸; Glycodeoxycholic acid	CFN96947	360-65-6	C₂₆H₄₃NO₅ = 449.63	20mg	QQ客服：1413575084
甘氨熊去氧胆酸; Glycoursodeoxycholic acid	CFN89075	64480-66-6	C₂₆H₄₃NO₅ = 449.63	20mg	QQ客服：3257982914
牛磺胆酸; Taurocholic acid	CFN96646	81-24-3	C₂₆H₄₅NO₇S = 515.70	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9169 mL	9.5844 mL	19.1688 mL	38.3377 mL	47.9221 mL
5 mM	0.3834 mL	1.9169 mL	3.8338 mL	7.6675 mL	9.5844 mL
10 mM	0.1917 mL	0.9584 mL	1.9169 mL	3.8338 mL	4.7922 mL
50 mM	0.0383 mL	0.1917 mL	0.3834 mL	0.7668 mL	0.9584 mL
100 mM	0.0192 mL	0.0958 mL	0.1917 mL	0.3834 mL	0.4792 mL