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  • 丹参酮IIB

    Tanshinone IIB

    产品编号 CFN99820
    CAS编号 17397-93-2
    分子式 = 分子量 C19H18O4 = 310.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The roots of Salvia miltiorrhiza
    产品名称 产品编号 CAS编号 包装 QQ客服
    丹参酮IIB CFN99820 17397-93-2 1mg QQ客服:1457312923
    丹参酮IIB CFN99820 17397-93-2 5mg QQ客服:1457312923
    丹参酮IIB CFN99820 17397-93-2 10mg QQ客服:1457312923
    丹参酮IIB CFN99820 17397-93-2 20mg QQ客服:1457312923
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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  • ...
  • 生物活性
    Description: Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the elevated Bax protein and decreased bcl-2 and caspase-3 proteins induced by staurosporine in rat cortical neurons; TSB is effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. TSB significantly inhibits the uptake of digoxin and vinblastine in membrane vesicles containing PgP or MRP1, moderately stimulates PgP ATPase activity, suggesting TSB is a substrate for PgP and MRP1 and that drug resistance to TSB therapy and drug interactions may occur through PgP and MRP1 modulation.
    Targets: P-gp | Bcl-2/Bax | Caspase | ATPase
    In vitro:
    Drug Metab Lett. 2007 Aug;1(3):205-17.
    Involvement of P-glycoprotein and multidrug resistance associated protein 1 in the transport of tanshinone IIB, a primary active diterpenoid quinone from the roots of Salvia miltiorrhiza, across the blood-brain barrier.[Pubmed: 19356045]
    Tanshinone IIB (TSB) is a major constituent of Salvia miltiorrhiza, which is widely used in treatment of cardiovascular and central nervous system (CNS) diseases such as coronary heart disease and stroke. This study aimed to investigate the role of various drug transporters in the brain penetration of Tanshinone IIB using several in vitro and in vivo mouse and rat models.
    The uptake and efflux of Tanshinone IIB in rat primary microvascular endothelial cells (RBMVECs) were ATP-dependent and significantly altered in the presence of a P-glycoprotein (P-gp) or multidrug resistance associated protein (Mrp1/2) inhibitor. A polarized transport of Tanshinone IIB was found in RBMVEC monolayers with facilitated efflux from the abluminal to luminal side. Addition of a P-gp inhibitor (e.g. verapamil) in both abluminal and luminal sides attenuated the polarized transport. In an in situ rat brain perfusion model, Tanshinone IIB crossed the blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier at a greater rate than that for sucrose, and the brain penetration was increased in the presence of a P-gp or Mrp1/2 inhibitor. The brain levels of Tanshinone IIB were only about 30% of that in the plasma and it could be increased to up to 72% of plasma levels when verapamil, quinidine, or probenecid was co-administered in rats. The entry of Tanshinone IIB to CNS increased by 67-97% in rats subjected to middle cerebral artery occlusion or treatment with the neurotoxin, quinolinic acid, compared to normal rats. Furthermore, The brain levels of Tanshinone IIB in mdr1a(-/-) and mrp1(-/-) mice were 28- to 2.6-fold higher than those in the wild-type mice.
    Tanshinone IIB has limited brain penetration through the BBB due to the contribution of P-gp and to a lesser extent of Mrp1 in rodents. Further studies are needed to confirm whether these corresponding transporters in humans are involved in limiting the penetration of Tanshinone IIB across the BBB and the clinical relevance.
    Phytother Res. 2008 Jun;22(6):846-50.
    Tanshinone IIB, a primary active constituent from Salvia miltiorrhiza, exerts neuroprotective effect via inhibition of neuronal apoptosis in vitro.[Pubmed: 18389485 ]
    Tanshinone IIB (TSB) is a major active constituent of the roots of Salvia miltiorrhiza (Danshen) widely used in the treatment of stroke and coronary heart disease in Asian countries.
    This study investigated the in vitro neuroprotective effects of TSB and the underlying mechanism. Co-treatment with TSB significantly inhibited the cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner. Consistently, TSB significantly reduced the DNA laddering caused by staurosporine in a concentration-dependent manner. TSB also suppressed the elevated Bax protein and decreased bcl-2 and caspase-3 proteins induced by staurosporine in rat cortical neurons.
    These findings indicated that TSB had a neuroprotective effect via inhibition of apoptosis. Further studies are warranted to investigate the role of other apoptosis-related signaling proteins and reperfusion-related mechanisms in the protective effect of TSB on neurons.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2216 mL 16.1082 mL 32.2165 mL 64.433 mL 80.5412 mL
    5 mM 0.6443 mL 3.2216 mL 6.4433 mL 12.8866 mL 16.1082 mL
    10 mM 0.3222 mL 1.6108 mL 3.2216 mL 6.4433 mL 8.0541 mL
    50 mM 0.0644 mL 0.3222 mL 0.6443 mL 1.2887 mL 1.6108 mL
    100 mM 0.0322 mL 0.1611 mL 0.3222 mL 0.6443 mL 0.8054 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去氢丹参酮IIA; 1,2-Didehydrotanshinone IIA CFN92165 119963-50-7 C19H16O3 = 292.3 5mg QQ客服:215959384
    丹参酮IIA; Tanshinone IIA CFN98952 568-72-9 C19H18O3 = 294.4 20mg QQ客服:215959384
    羟基丹参酮IIA; Hydroxytanshinone IIA CFN90353 18887-18-8 C19H18O4 = 310.35 5mg QQ客服:3257982914
    紫丹参酮甲; Przewaquinone A CFN92022 76843-23-7 C19H18O4 = 310.4 5mg QQ客服:3257982914
    3alpha-羟基丹参酮IIA; 3alpha-Hydroxytanshinone IIA CFN90352 97399-71-8 C19H18O4 = 310.35 5mg QQ客服:2056216494
    丹参酮IIB; Tanshinone IIB CFN99820 17397-93-2 C19H18O4 = 310.4 5mg QQ客服:2056216494
    丹参酸甲酯; Methyltanshinonate CFN92148 18867-19-9 C20H18O5 = 338.4 5mg QQ客服:1413575084
    丹参酮IIA磺酸钠; Sulfotanshinone IIA Sodium CFN99162 N/A C19H17NaO6S = 396.39 20mg QQ客服:3257982914





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