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  • 羟基丹参酮IIA

    Hydroxytanshinone IIA

    产品编号 CFN90353
    CAS编号 18887-18-8
    分子式 = 分子量 C19H18O4 = 310.35
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The roots of Salvia miltiorrhiza Bge.
    产品名称 产品编号 CAS编号 包装 QQ客服
    羟基丹参酮IIA CFN90353 18887-18-8 1mg QQ客服:2056216494
    羟基丹参酮IIA CFN90353 18887-18-8 5mg QQ客服:2056216494
    羟基丹参酮IIA CFN90353 18887-18-8 10mg QQ客服:2056216494
    羟基丹参酮IIA CFN90353 18887-18-8 20mg QQ客服:2056216494
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Universidad de Antioquia (Colombia)
  • FORTH-IMBB (Greece)
  • John Innes Centre (United Kingdom)
  • Charles Sturt University (Denmark)
  • University of Stirling (United Kingdom)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Instituto Politécnico de Bragan?a (Portugal)
  • University of Wuerzburg (Germany)
  • Kyung Hee University (Korea)
  • Regional Crop Research Institute (Korea)
  • Imperial College London (United Kingdom)
  • Monash University Malaysia (Malaysia)
  • Shanghai University of TCM (China)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Funct.2022, D1FO03838A.
  • Acta Agriculturae Scandinavica2015, 381-383
  • Molecules.2022, 27(21):7514.
  • Mol Pharm.2018, 15(8):3285-3296
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Nutrients.2017, 10(1)
  • Biomedicines.2021, 9(8):954.
  • Plant Sci.2020, 301:110656.
  • Phytomedicine.2021, 84:153501.
  • J-STAGE2015, 249-255
  • Inflammation2015, 38(1):445-55
  • Int. J. Mol. Sci.2022, 23(19), 11900.
  • Antioxidants (Basel).2021, 10(9):1435.
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Molecules.2022, 27(7):2093.
  • Eur J Pharmacol.2022, 917:174744.
  • Int J Mol Sci.2021, 22(19):10405.
  • Anticancer Res.2020, 40(10):5529-5538.
  • Food and Chemical Toxicology2020, 111221
  • Heliyon2020, 6(6):e04337.
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  • Antioxidants (Basel).2022, 11(8):1471.
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  • ...
  • 生物活性
    Description: Hydroxytanshinone ⅡA has good antiproliferative effect on SGC-7901,HeLa, and HepG 2 cell, the values of IC50 are 4.18, 6.08 and10.20 uM, respectively; it has tumor cell proliferation inhibition significantly stronger than the tanshinoneⅡA.
    In vitro:
    Rapid Commun Mass Spectrom. 2006;20(5):815-22.
    Simultaneous determination of tanshinone IIA and its three hydroxylated metabolites by liquid chromatography/tandem mass spectrometry.[Pubmed: 16470728]

    A rapid and sensitive method based on liquid chromatography/tandem mass spectrometry (LC/MS/MS) for the simultaneous determination of tanshinone IIA and its three hydroxylated metabolites, tanshinone IIB, hydroxytanshinone IIA and przewaquinone A, in a rat liver microsome was developed and fully validated. A single step of liquid-liquid extraction with ethyl acetate was utilized in this method. Chromatographic separation of the sample matrix from the analytes and the internal standard diazepam was performed using a Shim-pack VP-ODS analytical column. Detection was performed on a triple quadrupole tandem mass spectrometer equipped with an electrospray ionization source and operated in selected reaction monitoring (SRM) mode. The method was linear in the concentration range of 1-500 ng/mL for all analytes. The intra- and inter-day precisions (RSD %) were within 15% and deviations of the assay accuracies were within 15.0% for all analytes. The analytes proved to be stable during sample storage, preparation and analyses. This validated method was successfully applied to the enzyme kinetic study of tanshinone IIA in liver microsome.
    The elimination of tanshinone IIA and formation of tanshinone IIB and hydroxytanshinone IIA in the liver microsome all exhibited a sigmoidal kinetics profile. The formation of przewaquinone A shows a typical hyperbolic profile. In addition, this method has now been applied in the analysis of other bio-samples including plasma, urine, bile and feces.
    In vivo:
    Journal of Chromatography A Volume 1104, Issues 1–2, 3 February 2006, Pages 366–369
    Identification of tanshinone IIA metabolites in rat liver microsomes by liquid chromatography–tandem mass spectrometry[Reference: WebLink]
    Tanshinone IIA, the major component extracted from Radix salvia miltiorrhiza, has been observed to possess various kinds of pharmacological activities including antioxidant, prevention of angina pectoris and myocardial infarction and anticancer.
    Tanshinone IIA was incubated with rat liver microsomes and the resulting metabolites were identified by liquid chromatography/tandem mass spectrometry. The results showed the formation of three main hydroxyl metabolites. The three hydroxyl metabolites of tanshinone IIA were proved to be tanshinone IIB, hydroxytanshinone IIA and przewaquinone A by comparing the tandem mass spectra and the chromatographic retention time with that of the respective authentic compounds.
    Tanshinone IIB, hydroxytanshinone IIA and przewaquinone A are all the chemical components of total tanshinones. It was reasonable to presume that the three hydroxy metabolites of tanshinone IIA were pharmacologically active the same as tanshinone IIA and the total tanshinones.
    J Mass Spectrom. 2006 May;41(5):670-84.
    Characterization of metabolites of tanshinone IIA in rats by liquid chromatography/tandem mass spectrometry.[Pubmed: 16598708]
    The metabolism of tanshinone IIA was studied in rats after a single-dose intravenous administration.
    In the present study, 12 metabolites of tanshinone IIA were identified in rat bile, urine and feces with two LC gradients using LC-MS/MS. Seven phase I metabolites and five phase II metabolites of tanshinone IIA were characterized and their molecular structures proposed on the basis of the characteristics of their precursor ions, product ions and chromatographic retention time. The seven phase I metabolites were formed, through two main metabolic routes, which were hydroxylation and dehydrogenation metabolism. M1, M4, M5 and M6 were supposedly tanshinone IIB, hydroxytanshinone IIA, przewaquinone A and dehydrotanshinone IIA, respectively, by comparing their HPLC retention times and mass spectral patterns with those of the standard compounds. The five phase II metabolites identified in this research were all glucuronide conjugates, all of which showed a neutral loss of 176 Da. M9 and M12 were more abundant than other identified metabolites in the bile, which was the main excretion path of tanshinone IIA and the metabolites.
    M12 was the main metabolite of tanshinone IIA. M9 and M12 were proposed to be the glucuronide conjugates of two different semiquinones and these semiquinones were the hydrogenation products of dehydrotanshinone IIA and tanshinone IIA, respectively. This hydrogenized reaction may be catalyzed by the NAD(P)H: quinone acceptor oxidoreductase (NQO). The biotransformation pathways of tanshinone IIA were proposed on the basis of this research.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2222 mL 16.1108 mL 32.2217 mL 64.4434 mL 80.5542 mL
    5 mM 0.6444 mL 3.2222 mL 6.4443 mL 12.8887 mL 16.1108 mL
    10 mM 0.3222 mL 1.6111 mL 3.2222 mL 6.4443 mL 8.0554 mL
    50 mM 0.0644 mL 0.3222 mL 0.6444 mL 1.2889 mL 1.6111 mL
    100 mM 0.0322 mL 0.1611 mL 0.3222 mL 0.6444 mL 0.8055 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去氢丹参酮IIA; 1,2-Didehydrotanshinone IIA CFN92165 119963-50-7 C19H16O3 = 292.3 5mg QQ客服:215959384
    丹参酮IIA; Tanshinone IIA CFN98952 568-72-9 C19H18O3 = 294.4 20mg QQ客服:215959384
    羟基丹参酮IIA; Hydroxytanshinone IIA CFN90353 18887-18-8 C19H18O4 = 310.35 5mg QQ客服:2159513211
    紫丹参酮甲; Przewaquinone A CFN92022 76843-23-7 C19H18O4 = 310.4 5mg QQ客服:2056216494
    3alpha-羟基丹参酮IIA; 3alpha-Hydroxytanshinone IIA CFN90352 97399-71-8 C19H18O4 = 310.35 5mg QQ客服:2159513211
    丹参酮IIB; Tanshinone IIB CFN99820 17397-93-2 C19H18O4 = 310.4 5mg QQ客服:1413575084
    丹参酸甲酯; Methyltanshinonate CFN92148 18867-19-9 C20H18O5 = 338.4 5mg QQ客服:2056216494
    丹参酮IIA磺酸钠; Sulfotanshinone IIA Sodium CFN99162 N/A C19H17NaO6S = 396.39 20mg QQ客服:3257982914





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