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  • 去氢丹参酮IIA

    1,2-Didehydrotanshinone IIA

    去氢丹参酮IIA
    产品编号 CFN92165
    CAS编号 119963-50-7
    分子式 = 分子量 C19H16O3 = 292.3
    产品纯度 >=98%
    物理属性 Red powder
    化合物类型 Diterpenoids
    植物来源 The roots of Salvia miltiorrhiza
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    去氢丹参酮IIA CFN92165 119963-50-7 1mg QQ客服:2056216494
    去氢丹参酮IIA CFN92165 119963-50-7 5mg QQ客服:2056216494
    去氢丹参酮IIA CFN92165 119963-50-7 10mg QQ客服:2056216494
    去氢丹参酮IIA CFN92165 119963-50-7 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Med Ther. 2020, 20(1):94.
  • Phytomedicine.2022, 102:154183.
  • Enzyme and Microbial Technology2022, 110002.
  • J Anal Methods Chem.2022, 2022:2229500.
  • Plants (Basel).2020, 9(11):1422.
  • Cell Rep.2020, 32(11):108158.
  • Antioxidants (Basel).2022, 11(12):2496.
  • Front Pharmacol.2022, 13:806869.
  • Plants (Basel).2023, 12(1):163.
  • Sci Rep.2019, 9(1):18080
  • University of Central Lancashire2017, 20472
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  • Front Plant Sci.2021, 12: 648426.
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  • J of L. Chroma.&Related Tech2017, 252-258
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  • ...
  • 生物活性
    Description: 1,2-Didehydrotanshinone IIA shows inhibitory effects against acetyl- (AChE) and butyrylcholinesterase (BChE). It also possesses metal-chelation capacity.
    Targets: AChR | BChE
    In vitro:
    Phytochemistry. 2017 Jan;133:33-44.
    Selective in vitro and in silico butyrylcholinesterase inhibitory activity of diterpenes and rosmarinic acid isolated from Perovskia atriplicifolia Benth. and Salvia glutinosa L.[Pubmed: 27817931 ]
    Cholinesterase inhibition is one of the most treatment strategies against Alzheimer's disease (AD) where metal accumulation is also strongly associated with pathology of the disease.
    METHODS AND RESULTS:
    In the current study, we assessed inhibitory effect against acetyl- (AChE) and butyrylcholinesterase (BChE) and metal-chelating capacity of twelve diterpenes: arucadiol, miltirone, tanshinone IIa, 1-oxomiltirone, cryptotanshinone, 1,2-didehydromiltirone, 1,2-Didehydrotanshinone IIA, 1β-hydroxycryptotanshinone, 15,16-dihydrotanshinone, tanshinone I, isotanshinone II, 1(S)-hydroxytanshinone IIa, and rosmarinic acid, isolated from Perovskia atriplicifolia and Salvia glutinosa. The compounds were tested at 10 μg/mL using ELISA microtiter assays against AChE and BChE. QSAR and molecular docking studies have been also performed on the active compounds. All of the compounds showed higher [e.g., IC50 = 1.12 ± 0.07 μg/mL for 1,2-didehydromiltirone, IC50 = 1.15 ± 0.07 μg/mL for cryptotanshinone, IC50 = 1.20 ± 0.03 μg/mL for arucadiol, etc.)] or closer [1,2-Didehydrotanshinone IIA (IC50 = 5.98 ± 0.49 μg/mL) and 1(S)-hydroxytanshinone IIa (IC50 = 5.71 ± 0.27 μg/mL)] inhibition against BChE as compared to that of galanthamine (IC50 = 12.56 ± 0.37 μg/mL), whereas only 15,16-dihydrotanshinone moderately inhibited AChE (65.17 ± 1.39%). 1,2-Didehydrotanshinone IIA (48.94 ± 0.26%) and 1(S)-hydroxytanshinone IIa (47.18 ± 5.10%) possessed the highest metal-chelation capacity.
    CONCLUSIONS:
    The present study affords an evidence for the fact that selective BChE inhibitors should be further investigated as promising candidate molecules for AD therapy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4211 mL 17.1057 mL 34.2114 mL 68.4229 mL 85.5286 mL
    5 mM 0.6842 mL 3.4211 mL 6.8423 mL 13.6846 mL 17.1057 mL
    10 mM 0.3421 mL 1.7106 mL 3.4211 mL 6.8423 mL 8.5529 mL
    50 mM 0.0684 mL 0.3421 mL 0.6842 mL 1.3685 mL 1.7106 mL
    100 mM 0.0342 mL 0.1711 mL 0.3421 mL 0.6842 mL 0.8553 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    去氢丹参酮IIA; 1,2-Didehydrotanshinone IIA CFN92165 119963-50-7 C19H16O3 = 292.3 5mg QQ客服:1413575084
    丹参酮IIA; Tanshinone IIA CFN98952 568-72-9 C19H18O3 = 294.4 20mg QQ客服:1457312923
    羟基丹参酮IIA; Hydroxytanshinone IIA CFN90353 18887-18-8 C19H18O4 = 310.35 5mg QQ客服:2056216494
    紫丹参酮甲; Przewaquinone A CFN92022 76843-23-7 C19H18O4 = 310.4 5mg QQ客服:2159513211
    3alpha-羟基丹参酮IIA; 3alpha-Hydroxytanshinone IIA CFN90352 97399-71-8 C19H18O4 = 310.35 5mg QQ客服:215959384
    丹参酮IIB; Tanshinone IIB CFN99820 17397-93-2 C19H18O4 = 310.4 5mg QQ客服:2056216494
    丹参酸甲酯; Methyltanshinonate CFN92148 18867-19-9 C20H18O5 = 338.4 5mg QQ客服:2056216494
    丹参酮IIA磺酸钠; Sulfotanshinone IIA Sodium CFN99162 N/A C19H17NaO6S = 396.39 20mg QQ客服:215959384

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